| Douglas Briggs Partnership LLP | | 2002 |
| Douglas Fisher Antiques Ltd | Wholesale & retail | 2017 |
| Dovecote View Limited | Health & social care | 2003 |
| Downcote Management Limited | Real estate | 2008 |
| Downs View Nurseries Ltd. | Agriculture & fishing | 2003 |
| Doye Mosse Productions Ltd | Information & communication | 2018 |
| DP4031 Ltd | Professional & scientific | 2017 |
| DPE Investments 2 Limited | Construction | 2023 |
| DPE Investments Limited | Construction | 2021 |
| DPG Services Limited | Agriculture & fishing | 2021 |
| DPJ Properties Limited | Households | 2012 |
| Dpmh Limited | Financial services | 2023 |
| DR a Thomas Consultancy Limited | Health & social care | 2016 |
| DR C.L. Barton Limited | Professional & scientific | 2002 |
| DR Clare Sieber Ltd | Health & social care | 2020 |
| DR Fernando's Neurology Clinic Ltd | Health & social care | 2018 |
| DR M Wood Limited | Health & social care | 2012 |
| DR Stephen Carr-Bains Limited | Extraterritorial | 2013 |
| DR Tanner Medical Consultancy Limited | Health & social care | 2022 |
| Dragonfly Thai Massage Ltd | Other services | 2023 |
| Drawing Circles Limited | Professional & scientific | 1998 |
| Drayton House Associates Limited | Professional & scientific | 2025 |
| Dream Clinic Ltd | Professional & scientific | 2020 |
| Dreamobject Limited | Construction | 1992 |
| Dremora Ltd | Manufacturing | 2025 |
| Drewood Partners Limited | Professional & scientific | 2022 |
| DRF Masonry Ltd | Construction | 2022 |
| Drift Clifford Street Ltd | Hospitality | 2023 |
| Drift-In Cafe Ltd | Hospitality | 2015 |
| Drift-In Ltd | Hospitality | 2015 |
| Drift-In West Ltd | Hospitality | 2020 |
| Drift-In York Ltd | Hospitality | 2018 |
| Drifters.Ew Ltd | Hospitality | 2016 |
| Driftwood Cafe Emsworth Limited | Hospitality | 2019 |
| Drive (Bosham) Management Company Limited(The) | Households | 1967 |
| DRIVE33 Ltd | Information & communication | 2022 |
| Driverless BUS Ltd | Professional & scientific | 2015 |
| Driving Engagement Social Media Management Limited | Professional & scientific | 2022 |
| Drone Safe Register Limited | Professional & scientific | 2015 |
| Drone Surveys 4U Ltd | Professional & scientific | 2025 |
| Dsdb Holdings Limited | Financial services | 2024 |
| DSI Investments Limited | Financial services | 2015 |
| DSI Properties (Nerja) Limited | Households | 1986 |
| DSK Paving Ltd | Construction | 2007 |
| DSM PVT Ltd | Transport & logistics | 2021 |
| Dtai Ltd | Information & communication | 2021 |
| DTB Group Ltd | Professional & scientific | 2017 |
| DTC Healthcare Ltd | Health & social care | 2013 |
| DTD Recruitment Signium Limited | Administrative & support | 2023 |
| Dubois Estate Agents Ltd | Real estate | 2025 |
| Duckett Grove Management Ltd | Households | 2024 |
| Duffnote Ltd | Information & communication | 2003 |
| Dufose Estates Limited | Construction | 1990 |
| Duke Milking Solutions Limited | Wholesale & retail | 2019 |
| Duke Pubs Limited | Hospitality | 2023 |
| Duncan Mclean Holdings Ltd | Financial services | 2023 |
| Dunreyth Alpacas (Chichester) Limited | Agriculture & fishing | 2011 |
| DUP Holdings Limited | Extraterritorial | 2011 |
| Dv&D Group Ltd | Information & communication | 1999 |
| DW IFA Holdings Limited | Professional & scientific | 2023 |
| DW Trade Ltd | Other services | 2024 |
| Dwelling Developments Ltd | Construction | 2024 |
| Dykehurst Holdings Ltd | Real estate | 2024 |
| Dyson King (Architectural Ironmongers) Limited | Wholesale & retail | 1981 |
| E Collins Services Limited | Transport & logistics | 2010 |
| E Morgan Ltd | Arts & recreation | 2023 |
| E&A Group Holdings Ltd | Financial services | 2023 |
| E&A Property Ltd | Real estate | 2020 |
| E&P Estate Services Limited | Professional & scientific | 2025 |
| E-Training World Ltd | Information & communication | 2006 |
| E-Watts Ltd | Construction | 2019 |
| E. D. Wright Limited | Hospitality | 2007 |
| E.E. Olley & Sons Limited | Wholesale & retail | 1952 |
| E13 Ltd | Wholesale & retail | 2018 |
| Eagle Tutors Limited | Education | 2016 |
| Eames Motor Repairs Limited | Wholesale & retail | 2009 |
| Earnley Manor Close Residents Association Limited | Households | 1998 |
| Earshot Communications Cables Limited | Manufacturing | 2019 |
| Earshot Communications Headsets Limited | Information & communication | 2019 |
| Earshot Communications Hearing Limited | Information & communication | 2019 |
| Earshot Communications Limited | Information & communication | 2003 |
| Earshot Communications Safety Limited | Wholesale & retail | 2022 |
| Earshot Communications Sussex Limited | Information & communication | 2019 |
| Earth Catering Ltd | Hospitality | 2019 |
| Earthmonk Ltd | Wholesale & retail | 2014 |
| EAS Sussex Holdings Ltd | Financial services | 2024 |
| EAS Sussex Trading Ltd | Professional & scientific | 2024 |
| Easel Art and Craft Supplies Ltd | Wholesale & retail | 2024 |
| Easidoctor Ltd | Extraterritorial | 2022 |
| Easidream Ltd. | Health & social care | 2007 |
| East Beach Solutions Ltd | Administrative & support | 2013 |
| East Beach Stores Ltd | Wholesale & retail | 2012 |
| East Bracklesham Holdings Limited | Financial services | 2022 |
| East Head Impact | Health & social care | 2021 |
| East Pallant (Chichester) Management Company Limited | Households | 1998 |
| East Sussex Hydraulics Ltd | Manufacturing | 2021 |
| East Walls Hotel Ltd | Hospitality | 2020 |
| Eastcourt Estates (Sussex) Limited | Construction | 1996 |
| Eastergate Medical Aesthetics Ltd | Health & social care | 2024 |
| Eastgate Fashion Ltd | Wholesale & retail | 2019 |