| Coope Commercials Ltd | Wholesale & retail | 2018 |
| Cooper Chandler Developments Limited | Construction | 2018 |
| Cooper Motor Spares Limited | Wholesale & retail | 2001 |
| Coopers Property Estates Ltd | Real estate | 2026 |
| Copost Ltd | Information & communication | 2023 |
| Copper Beeches Limited | Health & social care | 2008 |
| Core Displays Ltd | Manufacturing | 2012 |
| Corky's Brands Limited | Manufacturing | 2006 |
| Cornerstone Education Consultancy Ltd | Professional & scientific | 2026 |
| Corrintec Limited | Manufacturing | 1992 |
| Corrtelco Ltd | Extraterritorial | 2023 |
| Cortworth Finance Limited | Professional & scientific | 1993 |
| Cortworth Limited | Professional & scientific | 1993 |
| Cosi Stove Installations Ltd | Construction | 2022 |
| Cosico Ltd | Other services | 2018 |
| Cosistay LLP | | 2018 |
| Cosmetic Repair Solutions (Dinnington) Ltd | Wholesale & retail | 2022 |
| Cosmetic Repair Solutions Limited | Wholesale & retail | 2002 |
| Cosmic Vibration Ltd | Administrative & support | 2023 |
| Cost Advice Services Limited | Administrative & support | 1995 |
| Coster Aerosols Limited | Manufacturing | 1967 |
| Costrux Ltd | Construction | 2026 |
| Cotchett Village Management Company Limited | Households | 2020 |
| Cotgrave Civils Limited | Construction | 2015 |
| Cottage Style Homes Ltd | Construction | 2000 |
| Cotton Yard Management Company Limited | Households | 2019 |
| Counsel Legal Consulting Ltd | Professional & scientific | 2020 |
| Country Made Ltd | Manufacturing | 2026 |
| Courage Community Support CIC | Health & social care | 2026 |
| Court View Management Company (Clowne) Limited | Real estate | 2016 |
| Coverworld Holdings Limited | Financial services | 2024 |
| Coverworld UK Limited | Manufacturing | 1990 |
| CP Cloud Innovations Ltd | Information & communication | 2025 |
| CP Environmental Ltd | Water & waste | 2013 |
| CPB Driver Hire Limited | Transport & logistics | 2019 |
| CPC Pro-Active Engineering Ltd | Professional & scientific | 2022 |
| CPL Systems Limited | Information & communication | 1984 |
| CPM Servicesuk Ltd | Construction | 2024 |
| CPR Development Limited | Construction | 2025 |
| CPR Pro Limited | Construction | 2024 |
| CPT Logistics Ltd | Manufacturing | 2024 |
| Cpwork Limited | Transport & logistics | 2018 |
| Crabb Accountancy Ltd | Professional & scientific | 2023 |
| Crabby Games Ltd | Information & communication | 2025 |
| Crabcakes Developments Ltd | Real estate | 2021 |
| Crag Solutions Limited | Professional & scientific | 2008 |
| Crawley Developments Limited | Professional & scientific | 2004 |
| Crawshaw Financial Services Ltd | Financial services | 2020 |
| Crazy Daizy Ltd | Extraterritorial | 2015 |
| Creased Cards Ltd | Wholesale & retail | 2013 |
| Create Revive Ltd | Manufacturing | 2021 |
| Create US Online Limited | Health & social care | 2015 |
| Creative Bespoke Carpentry and Building Services Limited | Construction | 2021 |
| Creative Business Brain Limited | Professional & scientific | 2022 |
| Creative Community Pottery CIC | Arts & recreation | 2024 |
| Creative Envelope Solutions Ltd | Construction | 2013 |
| Creative Garden Supplies Ltd | Wholesale & retail | 2012 |
| Creative Knight Ltd | Professional & scientific | 2018 |
| Creative Precision Limited | Information & communication | 2018 |
| Creative Tech Solutions Ltd | Wholesale & retail | 2021 |
| Creative Woodcrafts Limited | Manufacturing | 2015 |
| Creativity Sells Ltd | Information & communication | 2006 |
| Credit Training Limited | Professional & scientific | 2008 |
| Creditas Financial Holdings Limited | Financial services | 2013 |
| Creditas Financial Solutions Limited | Administrative & support | 2007 |
| Crewe Hotel Holdings Limited | Financial services | 2024 |
| Crewe Hotel Trading Limited | Hospitality | 2011 |
| Crikey Mikey Ltd | Manufacturing | 2020 |
| Crisp Networks Ltd | Information & communication | 2020 |
| Crit Ltd | Wholesale & retail | 2026 |
| Croc Marketing Limited | Administrative & support | 2013 |
| Crocsocial Technologies UK Ltd | Information & communication | 2018 |
| Croft Digital Ventures Limited | Financial services | 2022 |
| Croft Rail Engineering Ltd | Manufacturing | 2014 |
| Croft Veterinary Centres Limited | Professional & scientific | 2001 |
| Crom Couriers Ltd | Transport & logistics | 2019 |
| Cromford Court Ltd | Construction | 2022 |
| Cromford Holdings Limited | Wholesale & retail | 2017 |
| Cromford Steam Rally Society | Other services | 2000 |
| Crooked Beverage Co. Limited | Extraterritorial | 1993 |
| Crooked Ideas Ltd | Hospitality | 2014 |
| Crooked Pickle Co. Ltd | Manufacturing | 2018 |
| Crooked Spine CIC | Arts & recreation | 2020 |
| Crooked Spire Distillery Ltd | Manufacturing | 2025 |
| Crooked Spire Riding Club Limited | Arts & recreation | 2019 |
| Crooked Spire Software Limited | Information & communication | 2026 |
| Crookedspirecourierservices Limited | Transport & logistics | 2014 |
| Cross Car Sales Limited | Wholesale & retail | 2003 |
| Crossco 1465 Limited | Financial services | 2023 |
| Crossfit 252 Chesterfield Ltd | Arts & recreation | 2014 |
| Crown Canvas Limited | Manufacturing | 2026 |
| Crown Complex Professional Limited | Professional & scientific | 2022 |
| Crown Construction (East Midlands) Ltd | Construction | 2023 |
| Crown Dozia Cleaners Ltd | Administrative & support | 2023 |
| Crown Products International Limited | Manufacturing | 1985 |
| Crown Products Limited | Manufacturing | 1978 |
| Crozz Limited | Professional & scientific | 2014 |
| Cruise Holiday Club Ltd | Professional & scientific | 2011 |
| Cruise Holidays China Ltd | Extraterritorial | 2011 |
| Cruise Holidays Ltd | Extraterritorial | 2006 |