| Severn Rewinds Limited | Manufacturing | 2005 |
| Severn Sky Engineering Ltd | Professional & scientific | 2021 |
| Severn Valley Trailer Hire Limited | Administrative & support | 2023 |
| Severnside Safety Supplies Limited | Wholesale & retail | 1973 |
| Seymour Asset Management Limited | Professional & scientific | 2012 |
| Seymour Café (Gloucester) Limited | Hospitality | 2019 |
| SF Planning Limited | Professional & scientific | 2007 |
| SFK Investments Ltd | Real estate | 2024 |
| SFM Trading Limited | Professional & scientific | 2021 |
| SFS 2025 Ltd | Financial services | 2025 |
| SFS 2026 Ltd | Financial services | 2025 |
| SGA 1G Services Ltd | Health & social care | 2023 |
| SGA Property Ltd | Real estate | 2026 |
| SGA Services Ltd | Health & social care | 2020 |
| SGD Restaurants Ltd | Hospitality | 2012 |
| Shaca Consulting Ltd | Professional & scientific | 2022 |
| Shadowplay Media Ltd | Professional & scientific | 2003 |
| Shahram Bashir Ltd | Wholesale & retail | 2025 |
| Shakti Holdings Limited | Hospitality | 2021 |
| Shamiora Travels Ltd | Administrative & support | 2026 |
| Shami’S Premium Store Limited | Wholesale & retail | 2025 |
| Shaolin Co Ltd | Hospitality | 2025 |
| Shaping Ltd | Information & communication | 2018 |
| Sharav Limited | Hospitality | 2002 |
| Sharepoint Assist Limited | Information & communication | 2011 |
| Sharnford Road Solar Limited | Energy | 2022 |
| Sharp Edge BCS Limited | Professional & scientific | 2014 |
| Sharp Intelligent Solutions Limited | Information & communication | 2014 |
| Sharper Network Solutions Ltd | Professional & scientific | 2014 |
| Sharpeye Research Ltd | Administrative & support | 2023 |
| Sharwanii Ltd | Real estate | 2025 |
| Shaw Industries Ltd | Information & communication | 2017 |
| Shawcroft Consulting Ltd | Agriculture & fishing | 2010 |
| Shawn Mustoe Limited | Construction | 2006 |
| Shay-Joinery Ltd | Manufacturing | 2021 |
| Shbs Gloucestershire Limited | Professional & scientific | 2021 |
| SHE Scales Collective Ltd | Other services | 2024 |
| Shelfco 2023 Limited | Information & communication | 2024 |
| Shen Carter Studio Ltd | Professional & scientific | 2020 |
| Shender Group Ltd | Wholesale & retail | 2018 |
| Shender Houses Ltd | Real estate | 2021 |
| Sherant Limited | Health & social care | 2002 |
| Sherborne Consultancy Ltd | Professional & scientific | 2019 |
| Sherborne Contracting Limited | Construction | 2018 |
| Sherborne Estates South Limited | Real estate | 2019 |
| Sherborne Homes Limited | Construction | 2000 |
| Sherborne House Stables Residents Association Limited | Households | 1987 |
| Sherborne Park Residents Co. Limited | Households | 1981 |
| Sherbornes Holdings Limited | Financial services | 2022 |
| Sherbornes Solicitors Limited | Administrative & support | 2011 |
| Sherlock Homes 02 Limited | Real estate | 2025 |
| Sherlock Homes Limited | Extraterritorial | 1971 |
| Sherwood Properties (Bristol) Limited | Construction | 1983 |
| SHF Safeguarding Consultancy Limited | Health & social care | 2024 |
| Shffl Limited | Information & communication | 2020 |
| Shield Construction Cotswolds Ltd | Construction | 2024 |
| Shield House (Gloucester) Ltd | Financial services | 2024 |
| Shift Logic Limited | Manufacturing | 2019 |
| Shikimori RIP Ltd | Information & communication | 2025 |
| Shillingford Investments Limited | Real estate | 2025 |
| Shillingham Estate Ltd | Extraterritorial | 2011 |
| Shillingham Manor Farm Ltd | Extraterritorial | 2011 |
| Shillingham Vineyard LLP | | 2024 |
| Shimona Pinto Ltd | Information & communication | 2021 |
| Shire Cars Limited | Wholesale & retail | 2008 |
| Shire Project Services Ltd | Professional & scientific | 2021 |
| Shire Solutions INT. Ltd | Professional & scientific | 2020 |
| Shire Window Cleaning Ltd | Administrative & support | 2026 |
| Shires Chiropractic Clinic Ltd | Health & social care | 2013 |
| Shires Stability Holdco Ltd | Energy | 2025 |
| Shires Stability Ltd | Energy | 2021 |
| Shiva SAI Limited | Health & social care | 2025 |
| Shivhare Properties Limited | Real estate | 2025 |
| Shka Limited | Construction | 2015 |
| Shogun Logistics Ltd | Transport & logistics | 2020 |
| Shoot-Off (UK) Limited | Wholesale & retail | 2018 |
| Shootingfood Ltd | Professional & scientific | 2003 |
| Shopix Global Ltd | Wholesale & retail | 2026 |
| Shorade Bristol Limited | Wholesale & retail | 2003 |
| Shorade Cheltenham Ltd | Administrative & support | 2023 |
| Shorade Tonbridge Limited | Wholesale & retail | 2025 |
| Shorade UK Investments Ltd | Real estate | 2025 |
| Shorade UK Limited | Financial services | 2021 |
| Short Stay Cheltenham Ltd | Hospitality | 2026 |
| Short Stay CRA Limited | Hospitality | 2015 |
| Shouson Ltd | Real estate | 2009 |
| Shout OUT Safety Limited | Information & communication | 2016 |
| Shrewd Solutions Limited | Administrative & support | 2015 |
| Shri Siyaram Trading Ltd | Real estate | 2025 |
| Shunty Mcshuntface Ltd | Transport & logistics | 2018 |
| Shurdington Childminding Ltd | Health & social care | 2019 |
| Shurdington Motorcycle Training Ltd | Other services | 2025 |
| Shurdington News Ltd | Wholesale & retail | 2010 |
| Shurdington Road Developments Limited | Real estate | 2006 |
| Shurdington Road Management Limited | Households | 1987 |
| Shush (Cheltenham) Limited | Hospitality | 2016 |
| Shutters Inn Ltd | Hospitality | 2016 |
| Shyop Ltd | Wholesale & retail | 2020 |
| Siam Oasis Ltd | Hospitality | 2023 |
| Sibling Distillery Limited | Manufacturing | 2013 |