| DOC Services Limited | Wholesale & retail | 2004 |
| Dochosting Data Management Ltd | Information & communication | 2003 |
| Docsexpert Limited | Information & communication | 2010 |
| Documedix Ltd | Health & social care | 2025 |
| Dodo Games Ltd | Wholesale & retail | 2020 |
| Dodo Ship Broker Ltd | Professional & scientific | 2019 |
| Dog Charlie FOX Limited | Administrative & support | 2023 |
| Dolche Ltd | Wholesale & retail | 2020 |
| Dolloo Ltd | Wholesale & retail | 2010 |
| Dolly Reyes Gulfan Ltd | Health & social care | 2019 |
| Dolonix Limited | Health & social care | 2014 |
| Domdam Trans Ltd | Transport & logistics | 2024 |
| Domestix Services Limited | Other services | 2018 |
| Domici Limited | Health & social care | 2021 |
| Domiciliary Care Support Services Ltd | Administrative & support | 2022 |
| Domus Capital Limited | Real estate | 2025 |
| DON Cricket Ltd | Arts & recreation | 2014 |
| Don'T Break 345 Limited | Arts & recreation | 2009 |
| Donald Freeston Fresh Produce Limited | Wholesale & retail | 2023 |
| Donate and Share Ltd | Other services | 2024 |
| Donation Station Ltd | Professional & scientific | 2024 |
| Donna Grant Psychiatry Ltd | Health & social care | 2021 |
| Donovan&Donovan Ltd | Real estate | 2024 |
| Doodle Mats Ltd | Wholesale & retail | 2026 |
| Dosa Hub Ltd | Hospitality | 2021 |
| DOT100 Limited | Hospitality | 2014 |
| Double E Hand Car Wash Limited | Wholesale & retail | 2025 |
| Double Glazing Consultancy Ltd | Professional & scientific | 2021 |
| Douglas L Bates Ltd | Construction | 2022 |
| Douglas Salmon Properties Ltd | Real estate | 2016 |
| Douglas Winters Associates Limited | Energy | 2011 |
| Dove's Commercial Holdings Ltd | Real estate | 2019 |
| Dove's Group Ltd | Financial services | 2022 |
| Dove's Property Management Ltd | Real estate | 2022 |
| Dove's Property Services Ltd | Real estate | 2020 |
| Dove's Store Self Storage Ltd | Construction | 2023 |
| Dovedale Nursery C.I.C. | Education | 2010 |
| Dovesports Limited | Health & social care | 2022 |
| Dovetail Artisans Ltd | Construction | 2021 |
| Dowanhall Estates Ltd | Real estate | 2003 |
| Downcloud Limited | Real estate | 2013 |
| Downes to Earth Plumbing & Heating Ltd | Construction | 2026 |
| Downstrand Ltd | Administrative & support | 2006 |
| Doya Limited | Arts & recreation | 2023 |
| Dozzy Gadgets Ltd | Wholesale & retail | 2026 |
| DP College of Performing Arts Ltd | Education | 2025 |
| Dp&R Capital Partners Limited | Professional & scientific | 2025 |
| DPH Joinery Ltd | Construction | 2010 |
| DPR Holdings Limited | Real estate | 2017 |
| DR C W Bergh Limited | Health & social care | 2012 |
| DR Caterers Limited | Manufacturing | 2020 |
| DR Deadstock Limited | Health & social care | 2014 |
| DR L Bisati Limited | Health & social care | 2015 |
| DR M Mohamed Ltd | Health & social care | 2018 |
| DR Pola Limited | Health & social care | 2022 |
| DR Tax Training Ltd | Education | 2023 |
| DR Technology Ltd | Information & communication | 2026 |
| DR Vlad Ltd | Professional & scientific | 2017 |
| DR. Andre Buthe Equine Clinic Limited | Administrative & support | 2009 |
| Dr.Roxana Limited | Health & social care | 2025 |
| Draftsmith Ltd | Other services | 2011 |
| Dragonball Sports Limited | Arts & recreation | 2020 |
| Drainage & Dredging Ltd | Construction | 2017 |
| Drainage and Hygiene Services Limited | Water & waste | 1977 |
| Dramshed Group Ltd | Extraterritorial | 2023 |
| Draught Dispense Limited | Manufacturing | 2019 |
| Draw the Outline Limited | Real estate | 2021 |
| Drawkirn Ltd | Construction | 2016 |
| DRD Heating & Building Solutions Limited | Construction | 2025 |
| Dreadnought Adventure Tours Limited | Real estate | 2022 |
| Dreadnought Customs Limited | Wholesale & retail | 2017 |
| Dream Free Limited | Administrative & support | 2013 |
| Dreammaker Technology Ltd | Manufacturing | 2021 |
| Dreamworld Education and Training Ltd | Education | 2008 |
| Dressing UP Box Ltd | Arts & recreation | 2026 |
| Dresterton Limited | Administrative & support | 2019 |
| Drew Financial Modelling Ltd | Information & communication | 1998 |
| Drew Jewellery Ltd | Manufacturing | 2022 |
| Drewitt-Barlow Organization Ltd. | Real estate | 2023 |
| Drive Management Solutions Ltd | Professional & scientific | 2011 |
| Drive Swift Limited | Wholesale & retail | 2025 |
| Drivefields Limited | Administrative & support | 2003 |
| Driver Base UK Ltd | Administrative & support | 2011 |
| Drop Shop Hub Ltd | Wholesale & retail | 2024 |
| DRS Carpentry Ltd | Administrative & support | 2017 |
| DRV Cavendish Limited | Construction | 2015 |
| Drytop Roofing Limited | Construction | 2019 |
| DS GAS Utilities Limited | Energy | 2022 |
| DS Healthcare Group Ltd | Professional & scientific | 2026 |
| DSA Electrical Ltd | Construction | 2019 |
| DSC Financials Ltd | Information & communication | 2019 |
| DSG Roofing & Cladding Ltd | Construction | 2012 |
| DSK Developments Limited | Construction | 2000 |
| DSK Farming Limited | Agriculture & fishing | 1996 |
| DSN Contracts Limited | Construction | 2009 |
| DSS Properties Private Ltd | Real estate | 2025 |
| DST Estates Ltd | Real estate | 2020 |
| Dsyn-Em Ltd | Professional & scientific | 2026 |
| DSZ Spedition Ltd | Transport & logistics | 2021 |
| DTA Capital Ltd | Arts & recreation | 2026 |