| Studio 3D Limited | Real estate | 2021 |
| Studio Aule Limited | Manufacturing | 2024 |
| Studio Griffin Ltd | Professional & scientific | 2014 |
| Studio Lizonne Ltd | Professional & scientific | 2024 |
| Studio Ninety Five Barber Ltd | Other services | 2025 |
| Studio Serocold Limited | Professional & scientific | 2017 |
| Studio Silhouettes Limited | Other services | 1995 |
| Studio Systems UK Limited | Real estate | 2006 |
| Studio Twentyseven Design Ltd | Other services | 2018 |
| STUDIO2N'S Private Limited | Information & communication | 2012 |
| Studiosoundassist Ltd | Information & communication | 2026 |
| Study Success (Ssuk) Ltd | Education | 2024 |
| Studyexpress Ltd | Administrative & support | 2023 |
| Stul Ltd | Wholesale & retail | 2017 |
| Stunningbrows & Henna Studio Limited | Other services | 2023 |
| Sturt Farm Burford Ltd | Construction | 2016 |
| Style 90 Limited | Wholesale & retail | 2025 |
| Style Revival Ltd | Other services | 2019 |
| Styles & Sons Ltd | Real estate | 2025 |
| Styles Furniture Limited | Manufacturing | 2017 |
| Styles-Hudson Ltd | Health & social care | 2015 |
| Stääl Gym Supplies Ltd | Wholesale & retail | 2025 |
| SUB Zero Ltd | Construction | 2008 |
| SUB1 DCS Ltd | Information & communication | 2023 |
| Subbie App Ltd | Information & communication | 2026 |
| Subsea Communications Limited | Information & communication | 2018 |
| Subsea CW Ltd | Professional & scientific | 2024 |
| Subserv IT Ltd. | Information & communication | 2013 |
| Success Search Limited | Administrative & support | 2014 |
| Successfully Teaching Children Ltd | Education | 2023 |
| Sudbury Number One Limited | Households | 2023 |
| Sudman Carpentry Ltd | Construction | 2023 |
| Sudman Homes Ltd | Construction | 2023 |
| SUE Arif Consulting Limited | Information & communication | 2010 |
| SUE Wood Consulting Limited | Information & communication | 2009 |
| Suen's Holding Company Limited | Financial services | 2022 |
| Suffolk Lofts Ltd | Construction | 2019 |
| Sugar and Spice Designs Limited | Arts & recreation | 2016 |
| Sugar and Style Ltd | Wholesale & retail | 2026 |
| Sugar Hound Ltd | Wholesale & retail | 2025 |
| Sugar Palm Ltd | Hospitality | 2019 |
| Suits Plus Ltd | Wholesale & retail | 2017 |
| Suli Services Ltd | Water & waste | 2024 |
| Sullivan Security Solutions Limited | Administrative & support | 2026 |
| Sullivans Security Solutions Limited | Construction | 2012 |
| Sumfactors Ltd | Information & communication | 2018 |
| Summer Studio Ltd | Professional & scientific | 2025 |
| Summerdale Veterinary Centre Limited | Professional & scientific | 2001 |
| Summit Housing Developments Ltd | Construction | 2025 |
| Summit Mentality Ltd | Wholesale & retail | 2024 |
| Summit Revenue Solutions Ltd | Information & communication | 2026 |
| Sumo Systems Limited | Information & communication | 2006 |
| Sun Heat Limited | Construction | 2008 |
| Sun Plastics Limited | Manufacturing | 1972 |
| Sunbury Homes (Investments) Limited | Real estate | 2015 |
| Sunbury Projects Limited | Extraterritorial | 2012 |
| Suncrux Ltd | Information & communication | 2013 |
| Sunday Funday Clothing Limited | Wholesale & retail | 2024 |
| Sunderland UK Rental Ltd | Real estate | 2020 |
| Sunderland UK Rentals (a) Ltd | Real estate | 2021 |
| Sunderland UK Rentals (B) Ltd | Real estate | 2021 |
| Sunkari Properties Limited | Real estate | 2023 |
| Sunkari Travels and Tours Ltd | Information & communication | 2024 |
| Sunnyway Psychology and Play Therapy Ltd | Education | 2023 |
| Sunrise Elite Express Limited | Wholesale & retail | 2025 |
| Sunrise Midco Limited | Financial services | 2023 |
| Sunrise Nursery Limited | Education | 2015 |
| Sunrise Portfolio Ltd | Real estate | 2021 |
| Sunrise Research Limited | Administrative & support | 2016 |
| Sunrise Topco Limited | Financial services | 2023 |
| Sunset (Britain) Ltd | Wholesale & retail | 2025 |
| Sunset Crest Restaurants Ltd | Hospitality | 2025 |
| Sunset Luxury Travel Ltd | Administrative & support | 2023 |
| SUNSHINE2 Limited | Wholesale & retail | 2019 |
| Supastore.Co.Uk Limited | Extraterritorial | 1999 |
| Super Cleaning BVL Ltd | Administrative & support | 2025 |
| Super Profits Limited | Professional & scientific | 2020 |
| Super Stem Properties Limited | Real estate | 2025 |
| Superhero by Night Limited | Professional & scientific | 2013 |
| Supershroom Ltd | Manufacturing | 2019 |
| Superstar Productions Ltd | Arts & recreation | 2019 |
| Superthread IO Limited | Information & communication | 2020 |
| Supplier Technical Assistance Limited | Administrative & support | 2010 |
| Supplies 4 Business From Concisely Limited | Manufacturing | 2011 |
| Supplies by Landu Limited | Wholesale & retail | 2025 |
| SUPPLIES4BUSINESS Limited | Other services | 2019 |
| Supported Business Holdings Limited | Real estate | 2018 |
| Supported Business Limited | Administrative & support | 2012 |
| Supported Business Solutions Ltd | Information & communication | 2024 |
| Supported Giving Limited | Information & communication | 2019 |
| Supported Health Limited | Administrative & support | 2019 |
| Supporting Health (Essex) Limited | Health & social care | 2010 |
| Supreme Coaches Ltd | Extraterritorial | 2011 |
| Supreme Doors Ltd | Administrative & support | 2023 |
| Sure Security Solutions Limited | Administrative & support | 2020 |
| Sure Specialised Services Limited | Financial services | 2026 |
| Surf Property Limited | Hospitality | 2021 |
| Surfmax Ltd | Real estate | 2008 |
| Surgenor Holdings Limited | Real estate | 2019 |
| Surgipact Ltd | Health & social care | 2006 |