| SGD Global Investments Limited | Professional & scientific | 2021 |
| SGE Fire and Security Ltd | Construction | 2025 |
| SGH Auto Services Limited | Wholesale & retail | 2020 |
| SGL Surveyors Limited | Professional & scientific | 2023 |
| SGS Implant UK Limited | Administrative & support | 2020 |
| SH Leisure Services Ltd | Manufacturing | 2004 |
| SH Mortgage Consulting Limited | Financial services | 2025 |
| SH Vission Ltd | Health & social care | 2023 |
| SH Voja Limited | Construction | 2025 |
| Shadforth Holdings Limited | Financial services | 2021 |
| Shadforth Pharmaceutical Company Limited | Wholesale & retail | 1916 |
| Shadforth Properties Limited | Real estate | 2021 |
| Shadowfitnessx Ltd | Education | 2024 |
| Shads & Owen Ltd | Extraterritorial | 2014 |
| Shadytrade Limited | Information & communication | 2024 |
| Shah Residential Ltd | Real estate | 2026 |
| Shakestones Limited | Real estate | 2008 |
| Shakoor & Sons Ltd | Wholesale & retail | 2026 |
| Shalam Packaging Ltd | Manufacturing | 2011 |
| Shalam Thermoforming (UK) Limited | Financial services | 2023 |
| Shanam Private Limited | Real estate | 2025 |
| Shanghai House Ltd | Hospitality | 2022 |
| Shantaram Ltd | Real estate | 2024 |
| Shareholder Services Limited | Administrative & support | 2024 |
| Sharif Builders Ltd | Construction | 2025 |
| Sharleez Medics Limited | Health & social care | 2020 |
| Sharma & Associates Ltd | Professional & scientific | 2016 |
| Sharon Hosegood Associates Ltd | Professional & scientific | 2014 |
| Sharpshooters TV Limited | Information & communication | 2009 |
| Shaw & Company Business Ltd | Health & social care | 2013 |
| Shaw Restaurants Ltd | Hospitality | 2026 |
| Shayna IT Solutions Limited | Information & communication | 2019 |
| Shaytech Limited | Wholesale & retail | 2025 |
| Shazia Limited | Financial services | 2015 |
| SHE Loves YOU Limited | Professional & scientific | 2023 |
| Shedmead Limited | Real estate | 1998 |
| Shefford Dog Walking Limited | Other services | 2016 |
| Shefford Limited | Health & social care | 2010 |
| Shelby Media Limited | Information & communication | 2014 |
| Shelfspan Limited | Wholesale & retail | 1987 |
| Shemac Construction Limited | Construction | 2011 |
| Shenberg Auction Ltd | Wholesale & retail | 2024 |
| Shentalls Investments Ltd | Financial services | 2020 |
| Shepheard and Co Ltd | Professional & scientific | 2012 |
| Shepherd Farming Limited | Agriculture & fishing | 2024 |
| Shepherdrose Investments Limited | Real estate | 2018 |
| Shepherdrose Limited | Professional & scientific | 2002 |
| Sherbet Rainbow Ltd | Wholesale & retail | 2010 |
| Shernhall Properties Ltd | Real estate | 2021 |
| Shield Asset Management Limited | Real estate | 2013 |
| Shield Racing Limited | Arts & recreation | 2013 |
| Shifgrethor Limited | Information & communication | 2026 |
| Shigatsu Corporation Limited | Professional & scientific | 2022 |
| Shigatsu Holdings Limited | Professional & scientific | 2022 |
| Shigatsu Investments Limited | Professional & scientific | 2022 |
| Shika Foods Ltd | Hospitality | 2024 |
| Shikaya Limited | Hospitality | 2004 |
| Shine Consulting Services Limited | Information & communication | 2015 |
| Shine Partners Limited | Financial services | 2007 |
| Shine Sharpers Limited | Administrative & support | 2025 |
| Shiny Days Cleaning Essex Limited | Other services | 2018 |
| Ship Wharf Student Property Services Limited | Real estate | 2017 |
| Shire Foods Holdings Limited | Financial services | 2025 |
| Shirley Smith & Co Ltd | Professional & scientific | 1999 |
| Shiroma (UK) Limited | Other services | 1993 |
| Shiroma Property Ltd | Real estate | 2023 |
| Shish Empire Ltd | Hospitality | 2026 |
| Shish Meze UK Ltd | Hospitality | 2025 |
| Shivika Estates Ltd | Real estate | 2021 |
| Shivisha Limited | Real estate | 2024 |
| Shockiso Limited | Professional & scientific | 2020 |
| Shodix Technologies Limited | Information & communication | 2009 |
| SHOES4LIFE Ltd | Wholesale & retail | 2021 |
| Shogun Architecture & Design Ltd | Professional & scientific | 2015 |
| Shogun Architecture Ltd | Professional & scientific | 2016 |
| Shogun Studios Ltd | Extraterritorial | 2015 |
| Shogun Survey & Design Ltd | Information & communication | 2011 |
| Shona Ventures Limited | Professional & scientific | 2010 |
| Shoots & Leaves Limited | Extraterritorial | 2011 |
| Shopglashes Ltd | Wholesale & retail | 2020 |
| Shorecom Limited | Information & communication | 2015 |
| Shoreditch Art House Ltd | Wholesale & retail | 2025 |
| Shoreditch Property Limited | Transport & logistics | 1991 |
| Short MAT Players Tour Ltd | Arts & recreation | 2012 |
| Shorts Property Ltd | Real estate | 2025 |
| Show Staff Holdings Ltd | Financial services | 2018 |
| Shower Panels Warehouse Ltd | Wholesale & retail | 2019 |
| Showtime HGV Training Limited | Education | 2025 |
| Shrc Ltd | Professional & scientific | 2017 |
| Shri Isha Consultancy Limited | Information & communication | 2018 |
| Shrishti Property Limited | Real estate | 2019 |
| Shrishti Solutions UK Ltd | Information & communication | 2013 |
| Shrouder Optical Ltd | Wholesale & retail | 2019 |
| Shu-Shu Holdings Limited | Financial services | 2023 |
| Shubell Limited | Real estate | 2022 |
| Shubhi Limited | Information & communication | 2011 |
| Shukriev Ltd | Other services | 2022 |
| Shunrental Limited | Real estate | 2024 |
| Shutter & Shade Ltd. | Wholesale & retail | 2021 |
| Sibr Consulting Ltd | Information & communication | 2016 |