| Sapphire Adventures Limited | Administrative & support | 2018 |
| Sapphire Gentle Care Limited | Wholesale & retail | 2026 |
| Sara Housing Ltd | Real estate | 2022 |
| Sara Technology Ltd | Information & communication | 2011 |
| Sara Vesey Holt Ltd | Financial services | 2025 |
| Saracen Bridge Limited | Professional & scientific | 2023 |
| Sarah Bagley Ltd | Other services | 2025 |
| Sarah Goodridge Limited | Wholesale & retail | 2014 |
| Sarah Traders Ltd | Real estate | 2024 |
| Sardafine Limited | Wholesale & retail | 1975 |
| Saren Group Limited | Financial services | 2022 |
| Saren Homes Limited | Real estate | 2018 |
| Saren Property Limited | Real estate | 2021 |
| Sargnetcom Limited | Information & communication | 2013 |
| Sarks IT Solutions Limited | Information & communication | 2021 |
| Saros One Limited | Information & communication | 2018 |
| Saros Two Limited | Other services | 2021 |
| Sarvavya Global Services Ltd | Information & communication | 2024 |
| SAS Convenient Ltd | Wholesale & retail | 2023 |
| SAS Dent Ltd | Health & social care | 2024 |
| SAS Leasing and Lettings Ltd | Real estate | 2026 |
| Sash Property Holdings Ltd | Real estate | 2024 |
| Satellite Signals Limited | Information & communication | 1992 |
| Sathok Ltd | Hospitality | 2025 |
| Sattlin Ltd | Real estate | 2023 |
| Saunders Roofing Contractors Ltd | Construction | 2023 |
| Sav-Uk Ltd | Wholesale & retail | 2024 |
| Sava Art Ltd | Construction | 2012 |
| Savva Clothing Ltd | Wholesale & retail | 2024 |
| Saward Solutions Limited | Wholesale & retail | 2021 |
| Sawyerrs' House Limited | Information & communication | 2016 |
| Saxton 4X4 Limited | Wholesale & retail | 2003 |
| SAY Cheese Dentistry Ltd | Health & social care | 2013 |
| SAY HEY Friend Ltd | Information & communication | 2025 |
| Saysh Ltd | Other services | 2021 |
| Sazar Property Ltd | Real estate | 2025 |
| SB Supplies Ltd | Wholesale & retail | 2025 |
| SB3 Electrical Services Limited | Manufacturing | 2009 |
| SBC Business Services Limited | Professional & scientific | 2010 |
| SBN Advisors Limited | Financial services | 2003 |
| SBN Investment Holdings Ltd | Financial services | 2019 |
| Sbwoodtek Ltd | Manufacturing | 2023 |
| SC Bookkeeping Services Limited | Professional & scientific | 2020 |
| SC CAD Solutions Ltd | Professional & scientific | 2018 |
| SC Digital Marketing Ltd | Professional & scientific | 2024 |
| SC3 Electrical Limited | Construction | 2026 |
| SCA Global Holding Ltd | Real estate | 2020 |
| Scadaians Ltd | Information & communication | 2025 |
| Scaff & Co UK Ltd | Construction | 2021 |
| Scaffolding Access Limited | Construction | 1997 |
| Scaffoldpro Recruitment Limited | Administrative & support | 2025 |
| Scallywags Agency Ltd | Administrative & support | 2023 |
| Scalp Art Limited | Other services | 2022 |
| Scalp Sense UK Limited | Other services | 2019 |
| Scanes Property Limited | Real estate | 2021 |
| Scapha London Ltd | Professional & scientific | 2024 |
| Scapha Ltd | Professional & scientific | 2023 |
| Scarabs Digital Limited | Wholesale & retail | 2024 |
| Scarlett Fish Productions Ltd | Information & communication | 2023 |
| SCB Secretarial Services Limited | Other services | 2009 |
| SCB Structures Limited | Professional & scientific | 2023 |
| Scene Essex Ltd | Professional & scientific | 2026 |
| Scene London Ltd | Professional & scientific | 2026 |
| Scene Middle East Ltd | Construction | 2016 |
| Scenic Excursion Limited | Administrative & support | 2019 |
| SCG Investments Limited | Real estate | 2017 |
| Schemeserve Limited | Information & communication | 2000 |
| Schofi Limited | Extraterritorial | 2015 |
| School Finance Ltd | Professional & scientific | 2005 |
| Science Clinic Private Tutoring Ltd | Education | 2017 |
| Sciencex Ltd | Information & communication | 2017 |
| Scientia Advisers Limited | Professional & scientific | 2024 |
| Scion Developments Limited | Construction | 2007 |
| Scisep Ltd | Extraterritorial | 2006 |
| SCJ Associates Limited | Professional & scientific | 2013 |
| SCJ Presents Limited | Professional & scientific | 2025 |
| Scorpion Signs and Graphics Ltd | Manufacturing | 2025 |
| Scotech Cabling Solutions Limited | Information & communication | 2004 |
| Scott & COX Ltd | Construction | 2002 |
| Scott Hann Gymnastics Services and Consultancy Limited | Education | 2022 |
| Scott Mann Services Limited | Information & communication | 2014 |
| Scott Thompson Electrical Services Ltd | Construction | 2020 |
| Scout Groundworks Ltd | Construction | 2020 |
| Screenzled Holding Ltd | Financial services | 2019 |
| Screenzled Ltd | Professional & scientific | 2019 |
| SCS GB Group Limited | Financial services | 2021 |
| Scty Cinemas Limited | Construction | 2022 |
| Scty Entertainment Limited | Professional & scientific | 2020 |
| SD Driving School Ltd | Education | 2025 |
| Sd&Rw Investments Ltd | Real estate | 2022 |
| SDD International Limited | Wholesale & retail | 2008 |
| Sddt Infotech Limited | Administrative & support | 2023 |
| SDG Wealth Management Ltd | Financial services | 2019 |
| SDI Connect Ltd | Transport & logistics | 2018 |
| SDP Basement Ltd | Construction | 2015 |
| SDP Lettings Ltd | Real estate | 2026 |
| SDV 2031 ZDP PLC | Financial services | 2025 |
| SE Orient Engineering Limited | Professional & scientific | 2026 |
| Sea Breeze Trawlers Limited | Agriculture & fishing | 2002 |
| Sea Edge Beach House Limited | Hospitality | 2023 |