| Rotamec Limited | Manufacturing | 2001 |
| Sacrosanct Limited | Wholesale & retail | 2012 |
| Samantha Bryant Limited | Administrative & support | 2006 |
| Sandford Building Contractors Limited | Construction | 1999 |
| Sansum Solutions Group Limited | Administrative & support | 2016 |
| Sentinor Limited | Manufacturing | 2012 |
| SF Park Maintenance Limited | Hospitality | 2015 |
| SFP Letting Management Limited | Hospitality | 2015 |
| SFP Planning Development Limited | Professional & scientific | 2018 |
| SGF Group 2014 Ltd | Professional & scientific | 2026 |
| Sharpe Design Limited | Administrative & support | 2004 |
| Shaun Davies Services Ltd | Manufacturing | 2019 |
| Shroom Hound Ltd | Professional & scientific | 2025 |
| Silas Consulting Services Ltd | Professional & scientific | 2025 |
| Sillbill Social Limited | Professional & scientific | 2025 |
| Sm@Rt Limited | Information & communication | 2008 |
| SMT Custom Limited | Wholesale & retail | 2023 |
| Somerset CNC Ltd | Manufacturing | 2021 |
| Somerset Distillery Limited | Manufacturing | 2019 |
| Somerset Photo Booth Ltd | Arts & recreation | 2026 |
| Somersettlers Ltd | Real estate | 2020 |
| Soothr Ltd | Wholesale & retail | 2026 |
| South Devon Boat Sales Ltd | Hospitality | 2012 |
| South West Architectural Design Services Limited | Professional & scientific | 2017 |
| South West Blasting Limited | Wholesale & retail | 2022 |
| South West Hire Limited | Administrative & support | 2024 |
| Southern Structures & Hire Ltd | Extraterritorial | 2024 |
| Southwestnest Ltd | Real estate | 2026 |
| Speedflow Products Ltd | Wholesale & retail | 2003 |
| Spice Food Cheddar Ltd | Hospitality | 2020 |
| Stable Group Ltd | Financial services | 2016 |
| Stable London Limited | Financial services | 2020 |
| Station Court (WSM) Management Company Limited | Households | 1990 |
| Strawberryfield Park Ltd | Real estate | 2011 |
| STREETWISE3D Ltd | Manufacturing | 2022 |
| Sunhill Mansions Management Company Limited | Households | 1985 |
| Support Humans Ltd | Professional & scientific | 2025 |
| Suprema Group Limited | Manufacturing | 2016 |
| Surety Ventures Limited | Information & communication | 2024 |
| Susannah Hall Agencies Limited | Wholesale & retail | 2014 |
| Sweet Fencing Limited | Construction | 2018 |
| T& RR Ltd | Hospitality | 2025 |
| Takeoff Development Ltd | Professional & scientific | 2024 |
| Tateland Management Company Limited | Real estate | 1986 |
| Taylor Wigg Limited | Administrative & support | 2011 |
| Team Pro Scaffolding (SW) Ltd | Construction | 2020 |
| THE BIN Box Ltd | Manufacturing | 2022 |
| THE Black Dog Saloon Limited | Hospitality | 2014 |
| THE Cartridge Warehouse UK Limited | Wholesale & retail | 2024 |
| THE DE FEO Group Limited | Arts & recreation | 2025 |
| THE Foodservice Centre Instore Limited | Hospitality | 2001 |
| THE Gorge Bakehouse Ltd | Manufacturing | 2020 |
| THE Gorge Bear Company Limited | Wholesale & retail | 2002 |
| THE Healthy Retreat Company Ltd | Hospitality | 2014 |
| THE Pound Shop | | 2000 |
| THE Reel Community CIC | Education | 2026 |
| THE Somerset Laundry Room Ltd | Other services | 2025 |
| THE Strength Group Limited | Arts & recreation | 2017 |
| THE Touchwood Shop Ltd | Manufacturing | 2006 |
| THE Zero Drinks Company Limited | Wholesale & retail | 2026 |
| Thinking Opticians Ltd. | Health & social care | 2007 |
| Thrive and Shine Women's Wellness Ltd | Health & social care | 2023 |
| TLA 360 Ltd | Professional & scientific | 2020 |
| Top CAP Limited | Manufacturing | 2015 |
| Torke Systems Ltd | Education | 2012 |
| Total Enervation Ltd | Professional & scientific | 2025 |
| Totw CIC | Other services | 2025 |
| Touch Safe Ltd | Construction | 2015 |
| Toursareus Motogp Ltd | Administrative & support | 2015 |
| TTW Recruitment Limited | Professional & scientific | 2016 |
| Tweentown Management Company Limited | Households | 2019 |
| Two in One Ducting Limited | Construction | 2007 |
| Tyrewest Ltd | Wholesale & retail | 2022 |
| V-Lex (South West) Limited | Professional & scientific | 2016 |
| VBO Construction Ltd | Construction | 2004 |
| Vencida Group Limited | Wholesale & retail | 2001 |
| VPS Properties Ltd | Real estate | 2022 |
| W Mages (Rewinds) Limited | Manufacturing | 1987 |
| Wallis & Co. Financial Services Limited | Professional & scientific | 2022 |
| Warrens Hill Car & Commercial Limited | Extraterritorial | 2013 |
| Watermarket Limited | Manufacturing | 2014 |
| Wavelength LED Limited | Health & social care | 2026 |
| Wells Cathedral Stonemasons Limited | Construction | 1983 |
| Wessex Learning Trust | Education | 2010 |
| Westvale Group Limited | Wholesale & retail | 2026 |
| Will Sealey Cleaning Ltd | Administrative & support | 2016 |
| Willow and Brooke Property Management Limited | Real estate | 2026 |
| Wilmott Capital Group Ltd | Financial services | 2025 |
| Wirepilot Limited | Construction | 2000 |
| Woodbury Insurance Brokers Limited | Financial services | 1963 |
| Woodhouse Property Limited | Real estate | 2019 |
| Woodhouse Property Management Limited | Real estate | 2019 |
| Workplace Disability Solutions Limited | Health & social care | 2010 |
| World of Bears Limited | Extraterritorial | 2004 |
| WR Sauna Build Limited | Manufacturing | 2025 |
| YEO Consultancy Ltd | Professional & scientific | 2020 |
| Youngs Consult Limited | Professional & scientific | 2012 |
| Zalda Limited | Wholesale & retail | 2005 |