| Encompass Accounting Limited | Professional & scientific | 2002 |
| Encompass Secretarial Services Limited | Administrative & support | 2009 |
| Encore Consultancy Ltd | Professional & scientific | 2019 |
| Encure Ltd | Administrative & support | 2023 |
| Endo Engineering Ltd | Construction | 2023 |
| Endtime Evangelical Ministries | Other services | 2003 |
| Endura Group Limited | Wholesale & retail | 2015 |
| Endura Property Limited | Extraterritorial | 2015 |
| Enerflex (UK) Limited | Administrative & support | 1998 |
| Energ Properties Ltd | Real estate | 2023 |
| Energy Air Solutions Ltd | Construction | 2023 |
| Energy Capital Advisory Ltd | Professional & scientific | 2026 |
| Energy Saving Supermarket Limited | Extraterritorial | 2012 |
| Energy Trans Ltd | Manufacturing | 2019 |
| Enexus Space Data UK Limited | Information & communication | 2026 |
| Engineering Asset Management Ltd | Administrative & support | 2011 |
| Engineering Solutions (Tonbridge) Limited | Professional & scientific | 2017 |
| Enhancing Independence Care Limited | Public administration | 2024 |
| Enigma INT. Engineering Ltd | Professional & scientific | 2022 |
| ENNOV8TIVE Medical Consultancy Limited | Health & social care | 2025 |
| Enrg Electrical Services Limited | Administrative & support | 2016 |
| Enrich Machine Learning Ltd | Information & communication | 2017 |
| Enterprise England | Real estate | 2013 |
| Enterprise Office Equipment Ltd | Wholesale & retail | 1995 |
| Enticom Limited | Information & communication | 2019 |
| Enumero Services Limited | Wholesale & retail | 2017 |
| Enviro Tech Electrical Ltd | Construction | 2018 |
| Environ Coastal Homes (South Devon) Limited | Construction | 2010 |
| Environ Country Homes Limited | Construction | 1996 |
| Enzo Private Limited | Professional & scientific | 2014 |
| Enzo Properties Investment Ltd | Real estate | 2024 |
| Eokd Holdings LLP | | 2025 |
| EON Construction Ltd | Construction | 2024 |
| Ephyra Data Labs Limited | Information & communication | 2026 |
| Epic Property Empire Ltd | Real estate | 2024 |
| Eppixx Transport Ltd | Transport & logistics | 2017 |
| Equi-Chip Ltd | Construction | 2016 |
| Equity and Debt Limited | Extraterritorial | 2019 |
| ER Sports Therapy Ltd | Other services | 2007 |
| ERC Consultancy Limited | Professional & scientific | 2022 |
| Eripet Care Ltd | Professional & scientific | 2025 |
| Eris Bronn & Co Ltd | Construction | 2025 |
| Erisco Ltd | Wholesale & retail | 2025 |
| ERS Property Solutions Ltd | Professional & scientific | 2024 |
| ERS Solutions Limited | Professional & scientific | 2017 |
| Erudite Research Ltd | Information & communication | 2000 |
| ES Transport Services Ltd | Transport & logistics | 2018 |
| ES Transport Services Solution Ltd | Transport & logistics | 2019 |
| ESA Traders Ltd | Wholesale & retail | 2019 |
| ESA Trans Ltd | Transport & logistics | 2017 |
| ESM Legal Limited | Professional & scientific | 2023 |
| Espanade Limited | Real estate | 2005 |
| Esport Formats Limited | Information & communication | 2016 |
| Esquare LAB Ltd | Professional & scientific | 2015 |
| Essential Extra Plus Ltd | Wholesale & retail | 2026 |
| Essentials Care Plus Limited | Health & social care | 2020 |
| Essex Property Centre Ltd | Real estate | 2007 |
| Estade Locum Services Ltd | Health & social care | 2014 |
| Estars Healthcare Services Ltd | Health & social care | 2020 |
| Esteebee Ltd | Manufacturing | 2022 |
| Estelle Health and Wealth Limited | Professional & scientific | 2025 |
| Estmanco (Geffrey's Home S Bromley) Limited | Households | 1979 |
| Estore Worldwide Ltd | Wholesale & retail | 2012 |
| Etag Ventures Limited | Transport & logistics | 2013 |
| Eternal Tools Limited | Professional & scientific | 2014 |
| Ethos Pharmaceutical Ethics and Compliance Limited | Education | 2018 |
| Ethoseq Construction Advisors Limited | Professional & scientific | 2024 |
| Etiko IT Limited | Information & communication | 2010 |
| ETX Chatham Ltd | Wholesale & retail | 2024 |
| Eudaimon Co Limited | Information & communication | 2025 |
| Euden Services Ltd | Construction | 2018 |
| Euronet Limited | Other services | 2010 |
| Europa Networks Limited | Information & communication | 2001 |
| European Centre for Scholarly Research Limited | Information & communication | 2024 |
| European Vacuum Drainage Systems Ltd. | Construction | 2005 |
| EV Charge London Ltd | Construction | 2020 |
| Evangaline Consulting Ltd | Financial services | 2024 |
| Evans Homecare Ltd | Health & social care | 2021 |
| Event Naafi Limited | Wholesale & retail | 2018 |
| Eventus Branding Limited | Manufacturing | 2013 |
| Everbloom Aesthetics Ltd | Health & social care | 2026 |
| Everest Investments Limited | Financial services | 1997 |
| Evergreen Blue Property Group Ltd | Real estate | 2023 |
| Evergym Ltd | Wholesale & retail | 2025 |
| Everly Construction Ltd | Construction | 2025 |
| Eversync Technologies Limited | Information & communication | 2022 |
| Every Family Finance Limited | Financial services | 2019 |
| Everywhere Assistance Limited | Professional & scientific | 2013 |
| Evolution Estates Limited | Real estate | 2010 |
| Evolution Financial Planning Ltd | Financial services | 2012 |
| Evolution Properties South East Ltd | Real estate | 2019 |
| Evolve Children’S Care Ltd | Health & social care | 2024 |
| Excalibur Business Group Limited | Financial services | 2026 |
| Excel Academy Limited | Education | 2025 |
| Excel Inspection Solutions Ltd | Professional & scientific | 2021 |
| Excelmed Limited | Health & social care | 2011 |
| Exestone Property Group Ltd | Real estate | 2026 |
| Exis Technical Ltd | Professional & scientific | 2024 |
| EXPERTISE4PROPERTIES Limited | Real estate | 2025 |
| Exposhade Limited | Wholesale & retail | 2025 |