| Peak Retreats (Exeter) Limited | Real estate | 2016 |
| Penguin Creative Limited | Arts & recreation | 2015 |
| Pennymangle Limited | Wholesale & retail | 2012 |
| Percuro Limited | Health & social care | 2008 |
| Perry Street House Management Company Limited | Real estate | 2013 |
| Petchfield Healthcare Limited | Health & social care | 2014 |
| Pets Pantry (Chard) Limited | Wholesale & retail | 2020 |
| Phasegate Property Management Limited | Households | 1988 |
| Phoenix Engineering Company Limited | Manufacturing | 1905 |
| Pidgeon 2012 LP | | 2014 |
| Pier Health Group Limited | Health & social care | 2018 |
| Pilatez Ltd | Arts & recreation | 2025 |
| Pinacle Property Services Limited | Construction | 2005 |
| Pink Moon Estates Limited | Real estate | 2021 |
| PME Precision Ltd | Manufacturing | 2021 |
| Poliszakinom Ltd | Health & social care | 2024 |
| Poltergeist Theatre Ltd | Arts & recreation | 2020 |
| Poltreen Close Ltd. | Construction | 2011 |
| Pordewetha Ltd | Real estate | 2021 |
| Practical Reality Labs Ltd | Information & communication | 2024 |
| Primary Healthcare Consulting Limited | Health & social care | 2025 |
| Print Ideas Ltd | Wholesale & retail | 2019 |
| Professional Cable Solutions Ltd | Construction | 2021 |
| Purple FOX Books Ltd | Wholesale & retail | 2023 |
| QI QI Limited | Real estate | 2020 |
| Qiaoqi Online Store Ltd | Wholesale & retail | 2025 |
| Quality House Builders Ltd | Construction | 2012 |
| Qube Trading Ltd | Wholesale & retail | 2021 |
| Quik-Kuf International Limited | Administrative & support | 1993 |
| Quokka FX Limited | Information & communication | 2026 |
| R & D Motors Ltd | Wholesale & retail | 2018 |
| R Collins Architects Ltd | Professional & scientific | 2013 |
| R M Guinness Limited | Health & social care | 2019 |
| Ramshaw Medical Limited | Health & social care | 2025 |
| Rapid Estate Solutions Ltd | Real estate | 2024 |
| Rattlesnacks Ltd | Manufacturing | 2018 |
| RBC Plumbing Heating & Renewables Ltd | Construction | 2013 |
| React Training and Consultancy Ltd | Education | 2023 |
| Ready Salted Productions Ltd | Professional & scientific | 2025 |
| Real Life Counselling Limited | Administrative & support | 2011 |
| Red Engineering Group Ltd | Financial services | 2023 |
| Redball Pictures Limited | Information & communication | 2011 |
| Redefined Hospitality Limited | Financial services | 2026 |
| Redshield Building Services Limited | Construction | 2009 |
| Redstart Design Limited | Professional & scientific | 2006 |
| Rest Assured Hotel Management Ltd | Hospitality | 2023 |
| Retake Control Ltd | Health & social care | 2025 |
| Reujo Ltd | Professional & scientific | 2020 |
| Revill Medical Services Limited | Health & social care | 2024 |
| RH Candlelight Limited | Hospitality | 2025 |
| RH Cotley Limited | Hospitality | 2019 |
| Rhino Connect Limited | Administrative & support | 2024 |
| Ringside RTM Company Ltd | Households | 2025 |
| Rinkle's Cafe Ltd | Hospitality | 2025 |
| River AXE CIC | Professional & scientific | 2022 |
| Rocal 2010 LP | | 2010 |
| Rodney Wells Limited | Professional & scientific | 2022 |
| Rogers Medical Limited | Health & social care | 2019 |
| Rohaise Court (Uplyme) Management Company Limited | Other services | 2007 |
| Rooster BUS Ltd | Transport & logistics | 2016 |
| Ruddy Vans Ltd | Transport & logistics | 2025 |
| S J White Building Contractors Limited | Construction | 2009 |
| S W Motors & Fans Limited | Wholesale & retail | 2009 |
| S&Family Property Limited | Real estate | 2023 |
| S.W.D. Limited | Construction | 1982 |
| Safe H&S Support Ltd | Public administration | 2024 |
| Safety Intelligence Ltd | Professional & scientific | 2023 |
| Saffron Publishing Ltd | Information & communication | 2014 |
| Salem Services Limited | Professional & scientific | 1990 |
| Salty Seas Trading and Holding Company Limited | Information & communication | 2023 |
| SAM & Kates Farm CIC | Agriculture & fishing | 2026 |
| Samuel Bellamy Property Limited | Construction | 2013 |
| SCM Garage Doors Ltd | Wholesale & retail | 2025 |
| Scooby Investments Limited | Real estate | 2018 |
| Scrivs Precision Engineering Ltd | Professional & scientific | 2022 |
| Seamless Creative Productions Limited Liability Partnership | | 2025 |
| Sentinel One Holdings Ltd | Financial services | 2022 |
| Serotonin LDN Ltd | Wholesale & retail | 2020 |
| Serotonin VTG Limited | Wholesale & retail | 2016 |
| Sevben Care Staffing Limited | Administrative & support | 2026 |
| Seven Acres (Westford) Limited | Wholesale & retail | 2011 |
| Sherwood Project Services Ltd | Administrative & support | 2018 |
| Sheth Dermatology Limited | Health & social care | 2010 |
| Sheth Holdings Ltd | Health & social care | 2019 |
| Shill Psychiatry Limited | Health & social care | 2019 |
| Shires Garage & Engineering Company Holdings Ltd | Financial services | 2022 |
| Shoplynx Limited | Wholesale & retail | 2025 |
| Simerly Dating Limited | Other services | 2022 |
| Simon Bloy Ltd | Information & communication | 2012 |
| Simon Hitchens Ltd | Arts & recreation | 2014 |
| Sitelocal Property Management Limited | Households | 1990 |
| SJA360 Ltd | Construction | 2019 |
| Skilful Handyman Limited | Construction | 2021 |
| Skull Scuba Ltd | Manufacturing | 2025 |
| Slades Garage Limited | Wholesale & retail | 1995 |
| Slavi 1926 Ltd | Transport & logistics | 2019 |
| SLP Cross Limited | Manufacturing | 2023 |
| Smbs Ltd. | Agriculture & fishing | 2001 |
| Snow River Media Company Limited | Information & communication | 2004 |
| Solutions.It Consultancy Limited | Information & communication | 2010 |