| Sanderson Resourcing Ltd | Administrative & support | 2018 |
| Sansabars Ltd | Hospitality | 2025 |
| Sanskrit Limited | Education | 2024 |
| Santus Health Ltd | Health & social care | 2023 |
| Sarah Johnston Financial Limited | Financial services | 2018 |
| Sarsingh Limited | Wholesale & retail | 2021 |
| Sarumogi Ltd. | Financial services | 2025 |
| Saso (UK) Ltd | Wholesale & retail | 2012 |
| Save With Solar Ltd | Construction | 2023 |
| Saxon Pharmaceuticals Limited | Wholesale & retail | 2013 |
| SBA Properties Enterprise Limited | Real estate | 2025 |
| SBS Shopfitters Limited | Construction | 2012 |
| SCAFFOLD365 Industrial Limited | Construction | 2026 |
| SCC Scaffolding & Safety Netting Ltd | Construction | 2019 |
| SCJ Investments Ltd | Real estate | 2024 |
| Scott Lambert Lifting Ltd | Professional & scientific | 2020 |
| Scurrantesting Limited | Construction | 2024 |
| SDJ Driver Supply Ltd | Administrative & support | 2016 |
| SDW Electrical Limited | Construction | 2025 |
| Seamsil Limited | Extraterritorial | 1993 |
| Seaselkie Ltd | Manufacturing | 2025 |
| Secon-Uk Limited | Administrative & support | 2025 |
| Sedol Gifts Limited | Wholesale & retail | 2022 |
| Sensio Biolabs Ltd | Manufacturing | 2026 |
| Sensio Limited | Wholesale & retail | 2007 |
| Senworth Renewables Ltd | Construction | 2017 |
| Sferola Ltd | Professional & scientific | 2022 |
| Shadow Forge Ltd | Construction | 2025 |
| Shaman Investments Limited | Professional & scientific | 2009 |
| Shaman Properties Ltd | Real estate | 2017 |
| Sheep Group Limited | Manufacturing | 2026 |
| Shepherd and Levey Ltd | Manufacturing | 2020 |
| Shepherd for Homes Limited | Real estate | 2025 |
| Shining Rose Ltd | Health & social care | 2022 |
| Show Ready Limited | Manufacturing | 2026 |
| Shropshire Energy Partnerships Limited | Professional & scientific | 2020 |
| Shuropody IP Limited | Administrative & support | 2025 |
| Siam Sports Therapy Ltd | Other services | 2017 |
| Sigma Advantage Limited | Wholesale & retail | 2020 |
| Sigma Fixtures Solutions Limited | Manufacturing | 2009 |
| Sigma GRP Limited | Financial services | 2009 |
| Sigma M&E Limited | Construction | 2012 |
| Sigma Project Services Limited | Professional & scientific | 2013 |
| Sigma Retail Solutions Limited | Transport & logistics | 2007 |
| Signflow Yorkshire Limited | Construction | 2026 |
| Simasi Limited | Health & social care | 2015 |
| Simpler Safety Ltd | Professional & scientific | 2015 |
| Simply Inkjet Limited | Manufacturing | 2020 |
| Sizedwell Clothing Limited | Wholesale & retail | 2016 |
| SJ Miller Construction Ltd | Construction | 2021 |
| SJH Coaching Ltd | Administrative & support | 2025 |
| Skin Remedy Medical Aesthetics Limited | Health & social care | 2016 |
| SKR Food Courts Ltd | Hospitality | 2023 |
| Sky Emerald Properties Limited | Real estate | 2023 |
| Sky Watch Security Ltd | Professional & scientific | 2025 |
| SL Collections Limited | Extraterritorial | 2009 |
| SLC Insurance Recruitment Limited | Administrative & support | 2018 |
| Smart Digital Business Solutions Limited | Information & communication | 2008 |
| Smart Digital Service Limited | Information & communication | 2014 |
| Smart GAS Utilities Limited | Construction | 2010 |
| Smarthaul Fleet Ltd | Transport & logistics | 2025 |
| Smawthorne Lane Shop Limited | Wholesale & retail | 2025 |
| SMK Jointing Limited | Energy | 2017 |
| SNG (Yorkshire) Limited | Financial services | 2019 |
| Snooker School Community Interest Company | Education | 2025 |
| Snow Holdings Ltd | Real estate | 2020 |
| Social Singles Limited | Other services | 2004 |
| Solid Construction KK Ltd | Construction | 2023 |
| Solid Housing KK Ltd | Real estate | 2025 |
| Solupak Limited | Manufacturing | 1998 |
| Somerset Energy Partnerships Limited | Professional & scientific | 2020 |
| Sonia Developments Ltd | Real estate | 2024 |
| Sonya Yachting Limited | Manufacturing | 2025 |
| Spa School Limited | Extraterritorial | 2022 |
| Space DP Partners Limited | Professional & scientific | 2025 |
| Spear Scaffolding Services Ltd | Construction | 2010 |
| Specialist Power Engineering Contractors Ltd | Manufacturing | 2025 |
| Speed Driver Ltd | Transport & logistics | 2013 |
| Spekye Limited | Professional & scientific | 2016 |
| Spencersland Ltd | Real estate | 2025 |
| SPG & Brother Ltd | Transport & logistics | 2019 |
| SPG Rental Ltd | Administrative & support | 2019 |
| Spice Castleford Ltd | Hospitality | 2025 |
| Spice Villa Castleford Ltd | Hospitality | 2026 |
| Spion Property Services Limited | Administrative & support | 2014 |
| Sploosh Utilities Services Ltd | Construction | 2022 |
| Spolka Ltd | Wholesale & retail | 2023 |
| Sporogenesis Ltd | Wholesale & retail | 2023 |
| Sportsbox Castleford Ltd | Hospitality | 2025 |
| Sportsbox Rawmarsh Ltd | Hospitality | 2025 |
| Spowage Haulage Ltd | Transport & logistics | 2025 |
| Spring Fields Resident Management Company Limited | Households | 2026 |
| Spring Park (Grimethorpe) Ltd | Real estate | 2018 |
| Srb-Trans Ltd | Transport & logistics | 2023 |
| Sssk Investments Ltd | Real estate | 2024 |
| ST Swithins (Calder Gate) Resident Management Company Limited | Households | 2025 |
| ST Swithins (Wakefield) Resident Management Company Limited | Households | 2023 |
| Staffordshire Energy Partnerships Limited | Professional & scientific | 2020 |
| Stanhope Insulations Ltd | Manufacturing | 2014 |
| Stanley 85 Ltd | Transport & logistics | 2017 |