| Shillcar Limited | Real estate | 2021 |
| Shilton Accounting Services Limited | Professional & scientific | 2022 |
| Shilton Property Development Limited | Real estate | 2018 |
| Shilton Rose and Crown Limited | Hospitality | 2021 |
| Shipton Roofing Limited | Construction | 2019 |
| Shire Promotions Ltd | Hospitality | 2018 |
| Shopnest Enterprises Ltd | Wholesale & retail | 2025 |
| SIG Tooling (UK) Limited | Professional & scientific | 2014 |
| Simpson Soft UK Limited | Professional & scientific | 2005 |
| SJT Security Training Ltd | Education | 2026 |
| Skym Wrapson Johnston Consulting Limited | Professional & scientific | 2017 |
| SLJ Retreats Ltd | Real estate | 2024 |
| SMB Bearings Limited | Wholesale & retail | 1991 |
| SMC Carpentry & Oak Frames Ltd | Manufacturing | 2017 |
| SML Catering Ltd | Hospitality | 2023 |
| Smonk Consultants Ltd | Professional & scientific | 2011 |
| Solar Acre Ltd | Other services | 2025 |
| Soro Grill Ltd | Hospitality | 2018 |
| Soros Travel Ltd | Hospitality | 2024 |
| Southam Court (Carterton) Management Company Limited | Households | 2008 |
| Southam Electrical Bros Limited | Construction | 2011 |
| Spartan Scaffolding Contractors Ltd | Construction | 2023 |
| Specialist Cleaning Limited | Water & waste | 2023 |
| Spectrum Success Training Solutions Limited | Education | 2014 |
| SSH Affinity Limited | Other services | 2025 |
| Start Small Plan Big Limited | Professional & scientific | 2021 |
| STB Oxford Limited | Administrative & support | 2016 |
| Stephanie Smith Hairdressing Limited | Other services | 2017 |
| Steval Limited | Professional & scientific | 2004 |
| Steve Garey Consulting Limited | Professional & scientific | 2013 |
| Steve Sadler Property Ltd | Real estate | 2017 |
| Strae Capital Limited | Administrative & support | 2016 |
| Strata Digital Ltd | Information & communication | 2020 |
| Summitox Ltd | Professional & scientific | 2026 |
| Superswift Ltd | Financial services | 2025 |
| Suzi Coul Limited | Professional & scientific | 2026 |
| SW Building Oxford Ltd | Construction | 2020 |
| SW Grounds & Gardens Limited | Administrative & support | 2016 |
| Swinbrook Road (Carterton) Management Limited | Real estate | 2007 |
| T&C Floor Screeding Limited | Construction | 2022 |
| TAP to Tidy Ltd | Administrative & support | 2020 |
| Tarki Technology Limited | Information & communication | 1998 |
| Teasel England Limited | Manufacturing | 2006 |
| Tech Manage Ltd | Information & communication | 2019 |
| Tetbury Accounting Ltd | Professional & scientific | 2002 |
| Tetbury Company Secretarial Limited | Extraterritorial | 2011 |
| That Gorgeous Horse Limited | Wholesale & retail | 2012 |
| THE 5 Day Plan Limited | Hospitality | 2018 |
| THE Burford Festival | Arts & recreation | 2002 |
| THE Chapel Hill Group Ltd | Professional & scientific | 2024 |
| THE Corn Room Limited | Hospitality | 2025 |
| THE Cotswold Chef Limited | Hospitality | 2019 |
| THE Cotswold Couple Limited | Hospitality | 2025 |
| THE Fudgeboat Co Limited | Professional & scientific | 2014 |
| THE Oxford Fire Door Company Limited | Manufacturing | 2020 |
| THE Pink & Blue Bookkeeping Company Ltd | Professional & scientific | 2011 |
| THE PIT Stop Performance Ltd | Wholesale & retail | 2025 |
| THE Westbrook Hotel Company Ltd | Hospitality | 2021 |
| THE Westbrook PUB Company Ltd | Hospitality | 2020 |
| Thejames Sadler Oxford Balloon Experience Limited | Arts & recreation | 2009 |
| Three R'S Brickwork Limited | Construction | 2003 |
| Timberlake Ltd | Extraterritorial | 2025 |
| Tina Roberts Accounting Limited | Professional & scientific | 2012 |
| Toddle About Oxfordshire Limited | Information & communication | 2021 |
| Toddle About South Buckinghamshire Limited | Information & communication | 2022 |
| Top Deck Treasures UK Ltd | Wholesale & retail | 2025 |
| Triple TM Care Limited | Health & social care | 2014 |
| TSF Catering Ltd | Hospitality | 2020 |
| Tudor Andrei Ltd | Health & social care | 2018 |
| Turkuaz NS Health & Travel Ltd | Health & social care | 2024 |
| TWS Oxford Ltd | Information & communication | 2015 |
| TY Senior Limited | Arts & recreation | 2003 |
| Unirose Medical Limited | Wholesale & retail | 1982 |
| Upavon Limited | Wholesale & retail | 2015 |
| V4 Renewable Solutions Limited | Construction | 2023 |
| Vale Conservatory Company Limited | Construction | 2002 |
| Varooran Limited | Information & communication | 2016 |
| Vasil Transport Ltd | Transport & logistics | 2018 |
| Vera Benson Counselling Ltd | Health & social care | 2024 |
| Vicks Byway Garage LLP | | 2024 |
| Visage by Rachael Ltd | Other services | 2025 |
| Vitacoll Gold UK Limited | Wholesale & retail | 2005 |
| VJH Accountancy Ltd | Professional & scientific | 2003 |
| Walker House Property Management Limited | Households | 1990 |
| Walsh Project Solutions Ltd | Professional & scientific | 2007 |
| Warburton Property Limited | Real estate | 2019 |
| Warwick Capital Group Limited | Real estate | 2026 |
| WE ARE London Ltd | Administrative & support | 2022 |
| Weights for Soul Limited | Arts & recreation | 2017 |
| Welbydean Limited | Construction | 2024 |
| West Oxfordshire Roofing Limited | Construction | 2018 |
| WET Rock Adventures Ltd | Construction | 2025 |
| Whiddon Down Farm Shop Ltd | Real estate | 2017 |
| Whiteleaf Project Management Limited | Construction | 2013 |
| Wild & Kinch Properties Limited | Real estate | 2026 |
| Willwin Brothers Ltd | Real estate | 2024 |
| WIN Digital Ltd. | Administrative & support | 2006 |
| Wipotec-Ocs Limited | Manufacturing | 2000 |
| With Your Dog Limited | Information & communication | 2008 |
| Witney Commercials Ltd | Wholesale & retail | 2013 |