| S G Lift Ltd | Professional & scientific | 2018 |
| S K Electrical London Ltd | Construction | 2017 |
| S K New Union Limited | Wholesale & retail | 2026 |
| S L H Limited | Arts & recreation | 1933 |
| S&B Barbers Ltd | Other services | 2018 |
| S&K Investments (NE) Limited | Extraterritorial | 2019 |
| S&K Wrythe Management Limited | Real estate | 2021 |
| S&K Wrythe Properties Limited | Real estate | 2021 |
| S&N Cleaning Ltd | Administrative & support | 2021 |
| S&S Advertising Limited | Arts & recreation | 2014 |
| S.P. Cleaning Limited | Administrative & support | 1997 |
| S3NCONSULT Ltd | Professional & scientific | 2020 |
| SA Accountants & Tax Consultancy Ltd | Professional & scientific | 2008 |
| Saam Management Services Ltd | Health & social care | 2010 |
| Sadaqat Community Centre | Health & social care | 2014 |
| Sadera Company Limited | Wholesale & retail | 1982 |
| Safa & Co (UK) Ltd | Information & communication | 2015 |
| Safarovs Ltd | Wholesale & retail | 2020 |
| Safe Haven Property Group CIC | Households | 2025 |
| Safe Management Solutions Ltd | Construction | 2010 |
| Safedrive Services Ltd | Transport & logistics | 2023 |
| Sagearchbuild Ltd | Construction | 2026 |
| Saina Hair and Beauty Salon Limited | Other services | 2015 |
| Saji Properties Ltd | Real estate | 2019 |
| Sajn Traders Ltd | Wholesale & retail | 2019 |
| Saketh Enterprise Limited | Wholesale & retail | 2024 |
| Sallins Residential Limited | Real estate | 2021 |
| Sally Worm Limited | Manufacturing | 2013 |
| Salvage and Recycling Ltd | Other services | 2020 |
| Salya Properties Limited | Real estate | 2023 |
| SAM Import & Export Ltd | Wholesale & retail | 2019 |
| Sam's Gents Barbers Ltd | Other services | 2023 |
| Sam's Hairdressers Ltd | Other services | 2015 |
| Samchristelle Logistics Ltd | Transport & logistics | 2025 |
| Samtrend Ltd | Wholesale & retail | 2023 |
| SAN Wood Consulting Limited | Wholesale & retail | 2013 |
| Santhya Estates Ltd | Real estate | 2018 |
| Sapphirebd Ltd | Professional & scientific | 2024 |
| Saproots Limited | Information & communication | 2013 |
| Sarfraz Consultancy Services Ltd | Professional & scientific | 2025 |
| SAS Property Services (Surrey) Limited | Construction | 2015 |
| Sash Smart London Ltd | Construction | 2017 |
| Satyam Shivam Sundaram Computers Limited | Information & communication | 2010 |
| Savannah Care Limited | Health & social care | 2014 |
| SB & VB Limited | Wholesale & retail | 2024 |
| SB and SB PVT. Limited | Hospitality | 2020 |
| SB Plumbheat Ltd | Construction | 2025 |
| SBH Landscaping Ltd | Administrative & support | 2023 |
| Sbkr Limited | Professional & scientific | 2015 |
| Scarlet Ibis Limited | Real estate | 2023 |
| Schipp Brown Limited | Wholesale & retail | 2017 |
| Scott's Marketing & Systems Limited | Information & communication | 1995 |
| Sean Chan Company Limited | Real estate | 2020 |
| Seba Pharma Ltd | Wholesale & retail | 2025 |
| Sebuliba Ventures Ltd | Health & social care | 2022 |
| Secret Touch Ltd | Other services | 2015 |
| Seema Khan Advisory Limited | Professional & scientific | 2026 |
| Senreddy Ltd | Real estate | 2026 |
| Serenity Groomers Ltd | Other services | 2025 |
| Setlon Limited | Information & communication | 2010 |
| SGS Electrical & Building Services Limited | Construction | 2021 |
| Shahkeen Limited | Wholesale & retail | 2024 |
| Shajjeee Ltd | Real estate | 2021 |
| Shake Studios Limited | Administrative & support | 2006 |
| SHAMZOE4 Ltd | Other services | 2024 |
| Shan IT Solutions (PVT) Limited | Information & communication | 2012 |
| Shana Retail Ltd | Wholesale & retail | 2023 |
| Shasya Ltd | Real estate | 2025 |
| Shayan Properties Limited | Real estate | 2021 |
| Shetty Healthcare Limited | Health & social care | 2011 |
| Shetty Ventures Ltd | Real estate | 2025 |
| Shieldasset Limited | Wholesale & retail | 2000 |
| Shields Properties International Limited | Real estate | 2022 |
| Shikharam Solutions Limited | Information & communication | 2024 |
| Shine Bright Cleaners Ltd | Administrative & support | 2026 |
| Shine Bright Properties Ltd | Real estate | 2023 |
| Shirt Sleeve Disorder Ltd | Wholesale & retail | 2021 |
| Shivay Ventures Ltd | Financial services | 2024 |
| Shkh Corp Ltd | Hospitality | 2022 |
| Shoora Global Ltd | Information & communication | 2024 |
| Shooter Ready Limited | Wholesale & retail | 2022 |
| Shooting Stars Childcare Limited | Administrative & support | 2016 |
| Shopfaster Ltd | Wholesale & retail | 2020 |
| Shoppers Union Ltd | Administrative & support | 2023 |
| Shorebase (Surrey) Ltd | Administrative & support | 2012 |
| Shree Tech Ltd | Information & communication | 2023 |
| Shrewd Unisons Limited | Information & communication | 2024 |
| Shun Cheng Property Limited | Real estate | 2024 |
| Shutes Tattoos Ltd | Other services | 2021 |
| Si-Bling Property Ltd | Real estate | 2024 |
| Siam Vitality Ltd | Other services | 2025 |
| Sidm Construction Ltd | Construction | 2025 |
| Silver Lining Support Services Limited | Health & social care | 2025 |
| Silverleaf IT Solutions Ltd | Information & communication | 2020 |
| Silverman Black Group Ltd | Real estate | 2010 |
| Silverman Black Lettings Limited | Real estate | 2011 |
| Silverman Black Sales Limited | Real estate | 2011 |
| Simmetrics Ltd | Information & communication | 1997 |
| Simple FIX Ltd | Construction | 2013 |
| Simply Marvellous Productions Limited | Information & communication | 2010 |