| Schisis Limited | Health & social care | 2023 |
| Schorad Limited | Health & social care | 2022 |
| Sciart Consulting Limited | Construction | 2007 |
| Scotforth Local Limited | Wholesale & retail | 2020 |
| Scotland Court Milnthorpe Management Limited | Households | 2007 |
| Scott Wilson Body Shop Limited | Wholesale & retail | 2011 |
| SDR Investments Holdings Limited | Financial services | 2024 |
| Sea Glass Travel Limited | Administrative & support | 2025 |
| Seascape Properties and Rentals Limited | Real estate | 2020 |
| Seasons Bakery Denton Ltd | Hospitality | 2019 |
| Sedgwick House Management Company (1993) Limited | Households | 1993 |
| Seed Hill Guest House Ltd | Hospitality | 2019 |
| Sendemon Ltd | Arts & recreation | 2022 |
| Septic Tanks North West Ltd | Water & waste | 2026 |
| Serona Seven Ltd | Wholesale & retail | 2024 |
| SET Heating Engineers Ltd | Construction | 2025 |
| SGC Trading Subsidiary (1906) Ltd | Arts & recreation | 2026 |
| Shah Begum Limited | Administrative & support | 2016 |
| Sharisel Ltd | Agriculture & fishing | 2021 |
| Sharpe Access Solutions Limited | Construction | 2010 |
| SHE Sells Limited | Wholesale & retail | 2009 |
| Shelterworks Roofing Ltd | Construction | 2025 |
| Sheodessa Ltd | Wholesale & retail | 2020 |
| Shewee Limited | Wholesale & retail | 2014 |
| Shires Property Holdings Ltd | Administrative & support | 2023 |
| Shortacre Limited | Real estate | 1997 |
| Shovel Inn Carnforth Limited | Hospitality | 2020 |
| Shuna Consulting Ltd | Education | 2026 |
| Shuttleworth & Barr Limited | Construction | 2002 |
| Shuumi Ltd | Professional & scientific | 2021 |
| Sienna Jewellery Limited | Wholesale & retail | 2013 |
| Signature Automotive Limited | Wholesale & retail | 2005 |
| Sillfield Howe Management Company Limited | Households | 2024 |
| Silver Moon (2004) Limited | Wholesale & retail | 2004 |
| Silverdale Active Ltd | Other services | 2025 |
| Silverdale District Woodbank Ltd | Agriculture & fishing | 2015 |
| Simurgh Consulting Limited | Information & communication | 2024 |
| Sinclair Window Cleaning Services Ltd | Administrative & support | 2015 |
| Sirenna Learning Limited | Information & communication | 2010 |
| Siviter Anaesthetic Services Ltd | Health & social care | 2024 |
| SJ Property & Land Asset Group Ltd | Households | 2025 |
| SJA Building and Property Services Ltd | Construction | 2020 |
| SJA Plumbing & Heating Services Ltd | Construction | 2023 |
| SJB Tiling Limited | Construction | 2008 |
| SJG Partnership Limited | Professional & scientific | 2022 |
| SJW Auto Services Limited | Wholesale & retail | 2023 |
| Skills FIX Limited | Education | 2018 |
| SL Building Limited | Construction | 2015 |
| Slade Security Ltd | Administrative & support | 2023 |
| Slyne Developments Limited | Real estate | 2024 |
| Small Area Limited | Real estate | 2005 |
| Smart Design and Print Limited | Administrative & support | 2015 |
| Smartsignal Limited | Administrative & support | 2026 |
| SMG Mortgage & Protection Ltd | Financial services | 2019 |
| Solid Rock Solutions Cumbria Limited | Mining & quarrying | 2018 |
| South Bay CH Ltd | Wholesale & retail | 2023 |
| South Lakeland Hydrotherapy Limited | Health & social care | 2002 |
| South Lakes Civils & Groundworks Limited | Construction | 2020 |
| South Lakes Fencing Ltd | Construction | 2024 |
| South Lakes Support Services Ltd | Health & social care | 2025 |
| Southwell Stoves Ltd | Administrative & support | 2018 |
| Sovereign Education Limited | Education | 1977 |
| Spaceweaver Limited | Real estate | 2022 |
| Specialist Clean & Care North West Ltd | Water & waste | 2021 |
| Spiff Co Ltd | Information & communication | 2019 |
| Spillard Consultants Limited | Professional & scientific | 2017 |
| Splash Media Ltd. | Manufacturing | 2023 |
| SR Moore Ltd | Water & waste | 2020 |
| Stankelt House Management Company Limited | Extraterritorial | 2003 |
| Starmex Limited | Professional & scientific | 2006 |
| Station Garage (Arnside) Limited | Wholesale & retail | 2000 |
| Station Road Management (Arnside) Limited | Professional & scientific | 2016 |
| Stay on the Bay Ltd | Hospitality | 2020 |
| Steamtown Railway Museum Limited | Transport & logistics | 1967 |
| Step to IT Performing Arts Academy Ltd | Health & social care | 2013 |
| Stephen Road Management Company Limited | Real estate | 2013 |
| Stephens & Wright Asset Holdings Ltd. | Administrative & support | 2021 |
| Stephens Agriculture Ltd | Agriculture & fishing | 2024 |
| Steve Bingley Site Services Ltd | Extraterritorial | 2012 |
| Steve Everson Limited | Wholesale & retail | 2003 |
| Steve Hall Roofing Limited | Construction | 2012 |
| Still Insight Limited | Administrative & support | 2023 |
| Stomping Ground CIC | Education | 2011 |
| Stoneleigh Close Management Company (Silverdale) Limited | Water & waste | 1999 |
| Stormyam Properties Ltd | Real estate | 2025 |
| Storth Limited | Manufacturing | 2002 |
| Storth Machinery Limited | Manufacturing | 2014 |
| Strategy UX Ltd | Professional & scientific | 2021 |
| Striding Ahead LLP | | 2005 |
| Stringer Scaffolding Ltd | Construction | 2022 |
| Strong Developments Limited | Administrative & support | 2009 |
| Strongdor Holdings Limited | Financial services | 2018 |
| Strongdor Limited | Manufacturing | 2009 |
| Suggest in Salford Limited | Administrative & support | 2008 |
| Sunnii Lifestyle Ltd | Wholesale & retail | 2021 |
| Sunny Beck Limited | Hospitality | 2024 |
| Sunny Slopes Sales Ltd | Wholesale & retail | 2023 |
| Sunnycreek Properties Ltd | Real estate | 2019 |
| Svam Group Ltd | Professional & scientific | 2021 |
| SW Nuclear Limited | Professional & scientific | 2021 |