| Carluke CH Ltd | Hospitality | 2024 |
| Carluke Development Trust | Administrative & support | 1999 |
| Carluke Dignity Care Ltd | Health & social care | 2022 |
| Carluke Memorial Hall Limited | Hospitality | 2019 |
| Carluke Tandoori Limited | Hospitality | 2019 |
| Carluke Turkish Barber Ltd | Other services | 2023 |
| Carluke Tyre & Exhaust Ltd | Wholesale & retail | 2019 |
| Carluke Wash Ltd | Other services | 2019 |
| Castlehill Installations Ltd | Construction | 2024 |
| CBS Reform Ltd | Arts & recreation | 2025 |
| Central Letting Services (Glasgow UK) Ltd | Real estate | 2016 |
| CGT QP Ltd | Professional & scientific | 2025 |
| Cherrylocation Ltd | Wholesale & retail | 2024 |
| CJ Electrical & Solar Contractors Ltd | Construction | 2024 |
| CJ Jackson Ltd | Financial services | 2026 |
| CJB FM Ltd | Construction | 2026 |
| Clan Camper Trailers Ltd | Manufacturing | 2020 |
| Clayhills Engineering & PCM Services Limited | Professional & scientific | 2015 |
| Cleaning Penguins Ltd | Administrative & support | 2025 |
| Cleland Joiners and Builders Limited | Construction | 2015 |
| CLR Engineering Technical Services (UK) Ltd | Other services | 2018 |
| Clyde Agriculture (Seeds) Ltd. | Agriculture & fishing | 2002 |
| Clyde Joinery Ltd | Construction | 2012 |
| Clyde Valley Accounting Services Ltd | Professional & scientific | 2025 |
| Clyde Valley Antiques Ltd | Wholesale & retail | 2019 |
| Clyde Valley Fitting Ltd | Construction | 2023 |
| Clyde Valley Limos Limited | Transport & logistics | 2009 |
| Clyde Valley Ltd | Construction | 2025 |
| Clyde Valley Minibuses Ltd | Transport & logistics | 2020 |
| Clyde Valley Plumbing and Heating Ltd | Construction | 2025 |
| Clyde Valley Projects Ltd | Manufacturing | 2022 |
| Clyde Valley Renovations Limited | Construction | 2022 |
| Clyde Valley Wines Limited | Wholesale & retail | 2013 |
| Clydegrove Developments Limited | Construction | 2012 |
| Clydevale Property Services Limited | Real estate | 1987 |
| Clydevalley Roofing & Cladding Services Limited | Construction | 2021 |
| Cmgc Properties Ltd | Households | 2026 |
| Cockpen Garage Ltd | Wholesale & retail | 2019 |
| Codex Performance Ltd | Wholesale & retail | 2022 |
| Cognilist Ltd | Information & communication | 2025 |
| Coldstream Wind Community Limited | Energy | 2011 |
| Colin Mclellan Consultancy Ltd | Professional & scientific | 2022 |
| Corr Engineering Ltd | Construction | 2024 |
| Country Style Kitchens Limited | Manufacturing | 1985 |
| Craig Boyd Limited | Construction | 2016 |
| Craig White Barbers Ltd | Other services | 2024 |
| Crawford Kerr Elizabeth (CKE) Property Investments Ltd | Real estate | 2018 |
| CREA8 Services Limited | Information & communication | 2024 |
| Creative Foresight Solutions Ltd. | Manufacturing | 2019 |
| Creative Lifestyle Ninja Ltd | Real estate | 2022 |
| CRM Renovations Ltd | Construction | 2024 |
| Crossford Garage Limited | Wholesale & retail | 2015 |
| Crossford Holdings Limited | Real estate | 2025 |
| CROSSFORD25 Ltd | Construction | 2026 |
| Cruachan Consulting Limited | Extraterritorial | 2009 |
| CS FIC One Limited | Financial services | 2019 |
| CS Kitchens Limited | Manufacturing | 2011 |
| CTE Carluke Limited | Wholesale & retail | 2022 |
| Cunnin' Golf Design Limited | Construction | 2015 |
| Custom Chemicals ( Products ) Ltd | Other services | 2026 |
| Custom Chemicals ( Wishaw) Ltd | Other services | 2018 |
| Custom Chemicals (Scotland) Limited | Wholesale & retail | 2000 |
| D Cook Property Ltd | Real estate | 2021 |
| D&B Joinery Ltd | Manufacturing | 2018 |
| Dalziel Taxi's Limited | Transport & logistics | 2008 |
| Darios Fish and Chips Ltd | Hospitality | 2024 |
| David Mackay Mobile Welding Limited | Construction | 2003 |
| Davidson Lindsay Electrical Services Limited | Construction | 2010 |
| Davidson Plumbing Heating Ltd | Construction | 2023 |
| Dawn Robertson Hair Ltd | Other services | 2025 |
| Deadmen Music Limited | Arts & recreation | 2018 |
| DEC Maintenance Limited | Households | 2021 |
| Dehoney Ltd | Manufacturing | 2020 |
| Designer Homes 5 Limited | Wholesale & retail | 2019 |
| DGM Engineering Ltd | Manufacturing | 2022 |
| Dick Peddie & Mckay Limited | Professional & scientific | 2009 |
| Diginet-Uk Ltd. | Information & communication | 2018 |
| DMG UK Logistics Ltd | Transport & logistics | 2014 |
| Door 2 Door Flooring Ltd | Wholesale & retail | 2025 |
| DP Powercom Limited | Professional & scientific | 2016 |
| DSI Properties Limited | Construction | 2010 |
| DSN Elite Construction Ltd | Construction | 2025 |
| Dyno Files Ltd | Extraterritorial | 2026 |
| East Coast Holdings (TS) Ltd | Real estate | 2019 |
| Easy Market Carluke Ltd | Wholesale & retail | 2025 |
| EAT Move Breathe Ltd | Health & social care | 2021 |
| Eco Thermowood Imports Limited | Manufacturing | 2025 |
| Ecofix Scotland Ltd | Manufacturing | 2016 |
| Ecosse EV Ltd | Administrative & support | 1990 |
| EGL Contracts Ltd | Administrative & support | 2024 |
| Eilidhtranz Ltd | Transport & logistics | 2026 |
| EJ Trade Services & Logistics Ltd | Wholesale & retail | 2017 |
| EK Recycling Ltd | Water & waste | 2025 |
| EKR Holdings Ltd | Water & waste | 2025 |
| Elite Cleaning Solutions (Lanarkshire) Ltd | Administrative & support | 2016 |
| Elmac Limited | Information & communication | 2022 |
| ENF Holdings Limited | Financial services | 2019 |
| Envirosan Limited | Water & waste | 1997 |
| Eskergeo Limited | Information & communication | 2025 |
| EVO Mobility Group Ltd | Wholesale & retail | 2024 |