| Shakira Hair Limited | Other services | 2023 |
| Shane Hunter Rope Access Technicians Ltd | Professional & scientific | 2013 |
| Shankbridge END Farm Limited | Agriculture & fishing | 1975 |
| Sharat Vishwaraj Ltd | Health & social care | 2024 |
| Sharp Edge Events Ltd | Arts & recreation | 2018 |
| Sharp FVD Ltd | Wholesale & retail | 2025 |
| Sharp Smile DMD Ltd | Health & social care | 2025 |
| Shaun Ponticelli Ltd | Transport & logistics | 2025 |
| Shaun Stephens Consulting Ltd | Professional & scientific | 2026 |
| Shaw Wood Construction Ltd | Construction | 2021 |
| Shawstown Meadows Ltd | Agriculture & fishing | 2020 |
| Sheard Engineering Ltd | Professional & scientific | 2020 |
| Sheffield and Company,Limited | Agriculture & fishing | 1947 |
| Shepherds Gaming Supplies Limited | Wholesale & retail | 2025 |
| Sherriff Sales Agency Limited | Wholesale & retail | 2002 |
| Shield Agriculture Limited | Wholesale & retail | 2012 |
| Shine Threaded Brow and Beauty Ltd | Other services | 2022 |
| Shiny Car Wash (Carlisle) Limited | Other services | 2014 |
| Shipshape Ovens Limited | Other services | 2013 |
| Shirley Anne Gibson Ltd | Extraterritorial | 2024 |
| Shiyun Ltd | Wholesale & retail | 2022 |
| Shortdale Commercial Ltd | Professional & scientific | 2026 |
| Shorthorn Sires UK Limited | Agriculture & fishing | 1994 |
| Shorthorn Society of the United Kingdom of Great Britain and Ireland | Other services | 1875 |
| Show Services Group Limited | Extraterritorial | 2021 |
| SHP and J Property Investments LLP | | 2021 |
| Sian Chapman Horsemanship Ltd | Agriculture & fishing | 2025 |
| Siene Spa Ltd | Health & social care | 2026 |
| Sierra V Holdings Ltd | Real estate | 2024 |
| Sign and Deliver Limited | Manufacturing | 2010 |
| Signal Homecare Limited | Information & communication | 2026 |
| Signature Coatings Northern Limited | Construction | 2026 |
| Signature Properties Cumbria Ltd | Real estate | 2020 |
| Signature Road Markings Ltd | Construction | 2017 |
| Silloth Bowling Club Limited | Arts & recreation | 2019 |
| Silloth F&C Limited | Hospitality | 2025 |
| Silloth Takeaway Limited | Hospitality | 2025 |
| Silva Delivery Services Ltd | Extraterritorial | 2025 |
| Silver Grill (Carlisle) Limited(The) | Real estate | 1896 |
| Silversail Ltd | Financial services | 2018 |
| Simcar Enterprises Limited | Wholesale & retail | 2010 |
| Simongeo Limited | Professional & scientific | 2017 |
| Simpsons the Builders Ltd | Extraterritorial | 2004 |
| Simtor Limited | Construction | 1984 |
| Siorovig Ltd | Professional & scientific | 2024 |
| Sirant Limited | Professional & scientific | 2026 |
| Sire Contracting Ltd | Construction | 2024 |
| Site Evolution Limited | Construction | 2019 |
| SIW Groundworks Limited | Construction | 2026 |
| SIX Degrees Recruitment Limited | Administrative & support | 2012 |
| Sixmorphugus Ltd | Information & communication | 2022 |
| SJ & RR Logistics Ltd | Transport & logistics | 2018 |
| SJ Engineering Services Ltd | Construction | 2026 |
| Sj-Fit Limited | Other services | 2024 |
| SJB Specialised Joiners and Builders Ltd | Construction | 2011 |
| SJD Developments and Lettings Ltd | Real estate | 2016 |
| SJD Electrical Services (Cumbria) Limited | Construction | 2014 |
| SJD Joinery and Building Contractors Ltd | Construction | 2013 |
| SJD Properties (Cumbria) Limited | Real estate | 2020 |
| SJM Cumbria Limited | Construction | 2019 |
| SJM Offshore Solutions Ltd | Professional & scientific | 2023 |
| Sjnengineering Limited | Professional & scientific | 2020 |
| SJR Cleaning Cumbria Ltd | Administrative & support | 2025 |
| SJR Groundworks Ltd | Transport & logistics | 2023 |
| SJT Psychotherapies Ltd | Health & social care | 2026 |
| Skelton Court Management Limited | Real estate | 2016 |
| Sketch and SIP Limited | Hospitality | 2024 |
| SKI Property Holdings Limited | Real estate | 2024 |
| Skiddaw Cafe Limited | Hospitality | 2024 |
| Skiddaw MOT and Service Ltd | Wholesale & retail | 2025 |
| Skiddaw Transport Ltd | Transport & logistics | 2025 |
| Skiddaw Warehousing and Distribution Ltd | Transport & logistics | 2021 |
| Skies Electrical Services Ltd | Energy | 2024 |
| Skies Property Group Ltd | Real estate | 2026 |
| Skills for Logistics Passport Limited | Education | 2020 |
| Skip to the LOO Ltd | Construction | 2026 |
| Skipnets UK Limited | Water & waste | 2007 |
| Skippers Mill Ltd | Extraterritorial | 2018 |
| Skitby Developments Limited | Construction | 2017 |
| Skitby House Ltd | Hospitality | 2025 |
| Skool Bar Limited | Hospitality | 2024 |
| Skoshi Design Limited | Professional & scientific | 2017 |
| Skyblue in the Lakes Ltd | Real estate | 2023 |
| Skyden Roof Tents Ltd | Wholesale & retail | 2025 |
| Skylight Roofing Services Limited | Construction | 2025 |
| Skyline Sealants Limited | Construction | 2021 |
| Skysweep Surveys Ltd | Information & communication | 2025 |
| Skywood Estates (North) Ltd | Real estate | 2024 |
| SL Services Cumbria Limited | Information & communication | 2006 |
| Slackdean Limited | Real estate | 1979 |
| Slater Hair Limited | Other services | 2023 |
| Sleep Patrol CIC | Health & social care | 2024 |
| Sliding Sash Window Company | Professional & scientific | 2001 |
| Sliptorquecurve Limited | Administrative & support | 2025 |
| Sloantrans European Bulk Ltd | Transport & logistics | 2024 |
| Slough Transport Limited | Transport & logistics | 2024 |
| SLS Browns Ltd | Real estate | 2025 |
| SLX Data Structures (UK) Ltd | Professional & scientific | 2021 |
| SM County Deliveries Ltd | Transport & logistics | 2023 |
| SM County Ltd | Construction | 2018 |