| Roze Ltd | Wholesale & retail | 2023 |
| RR18 Private Ltd | Health & social care | 2023 |
| RRS Products | | 1993 |
| RS Hospitality Solutions Limited | Professional & scientific | 2017 |
| RSH Homes (North) Ltd | Construction | 2025 |
| RSH Properties (North) Ltd | Real estate | 2021 |
| RSM Countryside Services Ltd | Construction | 2025 |
| RTU Optical Limited | Wholesale & retail | 2006 |
| Rural Communication Solutions (North) Limited | Administrative & support | 2020 |
| Rural Land Agency Limited | Extraterritorial | 2021 |
| Russell Woods Electrical Services Ltd | Construction | 2017 |
| Rustle Ltd | Agriculture & fishing | 2024 |
| Ruthenium Solutions Ltd | Information & communication | 2018 |
| Rutherscar Limited | Agriculture & fishing | 2020 |
| Rutmark Properties Limited | Real estate | 2000 |
| RVG Holdings Ltd | Extraterritorial | 2016 |
| Ryan Maxwell Ltd | Other services | 2024 |
| Rydal Court Property Management Company Limited | Extraterritorial | 2007 |
| Rydal Ribs Limited | Wholesale & retail | 2020 |
| RYE Close Farming Company | Administrative & support | 2011 |
| S & A.W. Mcconnell Limited | Real estate | 2025 |
| S & D Property Northwest Limited | Real estate | 2025 |
| S & D Smith Limited | Transport & logistics | 2003 |
| S & G Sealed Units Limited | Manufacturing | 1999 |
| S & J Construction (NW) Ltd | Construction | 2009 |
| S & P Filters (Northern) Limited | Water & waste | 2010 |
| S & T Performance (NW) Ltd | Wholesale & retail | 2025 |
| S + J Crown & Bridge Limited | Manufacturing | 2005 |
| S C Forestry Ltd | Agriculture & fishing | 2021 |
| S D Wood Limited | Construction | 2013 |
| S Dinwoodie Contractors Limited | Construction | 2006 |
| S H & J E Dennison Limited | Agriculture & fishing | 2002 |
| S H Electrical UK Limited | Construction | 2006 |
| S J & K Holliday Limited | Professional & scientific | 2017 |
| S J Baird Limited | Agriculture & fishing | 2006 |
| S J Mcgahan (Forestry) Ltd | Agriculture & fishing | 2017 |
| S J Scientific Limited | Professional & scientific | 2010 |
| S J W Mechanical Limited | Construction | 2012 |
| S L Electrical (Northern) Limited | Construction | 2010 |
| S M Flooring Limited | Construction | 2000 |
| S Mallin Access & Fabrication Solutions Limited | Professional & scientific | 2017 |
| S R & L Irving Ltd | Hospitality | 2018 |
| S Reid Roofing Ltd | Construction | 2025 |
| S W Jermy Limited | Transport & logistics | 2007 |
| S W Stoves Limited | Construction | 2007 |
| S&J Development (Cumbria) Ltd | Real estate | 2025 |
| S&P&M Consultant Limited | Professional & scientific | 2025 |
| S&R Bricklayers Ltd | Construction | 2023 |
| S&S Groundworks Limited | Construction | 2021 |
| S&Y Storz Ltd | Wholesale & retail | 2025 |
| S. Howe Construction Services Ltd | Construction | 2015 |
| S. J. Montgomery Limited | Construction | 2024 |
| S. Redmayne Limited | Manufacturing | 1981 |
| S. T. Milligan Limited | Administrative & support | 2014 |
| S.A. Associates Management Training Limited | Education | 2002 |
| S.E. Drake Holdings Ltd | Financial services | 2026 |
| S.Farish Roofing Ltd | Construction | 2024 |
| S.H Plumbing Services Limited | Construction | 2025 |
| S.K.S.Deliveries Ltd | Transport & logistics | 2025 |
| S.T.E.A.M Arena Social Enterprises Ltd | Extraterritorial | 2024 |
| SA Cumbria Limited | Hospitality | 2019 |
| SA Dawson Logistics Ltd | Transport & logistics | 2025 |
| SA Properties (Birmingham) Limited | Wholesale & retail | 1994 |
| Saarah Property Limited | Real estate | 2024 |
| Sadler Woods LLP | | 2023 |
| Saeng Aran Limited | Hospitality | 2019 |
| Safa Diagnostics Limited | Health & social care | 2011 |
| Safety Comes First Limited | Education | 2017 |
| Safford Farms Limited | Agriculture & fishing | 2019 |
| Safford Holdings Limited | Real estate | 2019 |
| Safi Biosolutions UK Limited | Professional & scientific | 2021 |
| Saint & Co Trustees Limited | Extraterritorial | 2024 |
| Saint Financial Services Limited | Extraterritorial | 1999 |
| Saint Queens Limited | Construction | 2025 |
| Saintfield Lodge (Spring) Limited | Health & social care | 2019 |
| Saints Contracting Ltd | Construction | 2025 |
| SAJ Utilities Limited | Construction | 2025 |
| Salaplot Limited | Households | 1989 |
| Sally's Warwick Bridge Limited | Hospitality | 2016 |
| Salovena Limited | Hospitality | 2026 |
| SAM Greig Planning (Cumbria) Limited | Professional & scientific | 2018 |
| SAM Greig Planning Limited | Professional & scientific | 2017 |
| Samanco Limited | Other services | 2016 |
| Sambella Ltd | Financial services | 2024 |
| Same Day Courier Europe Ltd | Transport & logistics | 2018 |
| Samedi Dimanche Ltd | Information & communication | 2025 |
| Sameer Ltd | Hospitality | 2020 |
| Sami Barber Shop Limited | Other services | 2026 |
| Samviv Partners Ltd | Administrative & support | 2025 |
| Sancti Spiritus Limited | Hospitality | 2018 |
| Sandec Safety Systems Ltd | Construction | 2019 |
| Sanders Brow (Armathwaite) Management Company Limited | Households | 2019 |
| Sanderson Safety Ltd | Professional & scientific | 2018 |
| Sandham Carmidy Ltd | Professional & scientific | 2025 |
| Sandpiper Safety Solutions Ltd | Professional & scientific | 2025 |
| Sandra Jane Archibald Ltd | Extraterritorial | 2025 |
| Sandsfield Windows Limited | Construction | 2021 |
| Sandwich Club Deli Limited | Hospitality | 2006 |
| Sandwood Investing Limited | Administrative & support | 2017 |
| Sandyland Properties Limited | Real estate | 2009 |