| Dmsd North West Limited | Real estate | 2021 |
| Dmtp Ltd | Hospitality | 2025 |
| DNL Technical Support Limited | Professional & scientific | 2024 |
| Dodd & Co Audit Limited | Professional & scientific | 2022 |
| Dodd & Co Limited | Professional & scientific | 2001 |
| Dodd & Co Trust Corporation Limited | Administrative & support | 2022 |
| Dodd Wealthcare Limited | Extraterritorial | 2022 |
| Dodo Inc Ltd | Information & communication | 2022 |
| Doig Communications Limited | Information & communication | 2003 |
| Dolau Farm Limited | Agriculture & fishing | 2020 |
| Dollywagon Limited | Professional & scientific | 2006 |
| Dolores Marshall Opticians Limited | Health & social care | 2008 |
| Dolphenby Farming Ltd | Agriculture & fishing | 2023 |
| Donaldson's Damp Proofing Limited | Construction | 2016 |
| Donleys Limited | Professional & scientific | 2005 |
| Donna Lund Ltd | Health & social care | 2026 |
| Doocey North East Limited | Construction | 1997 |
| Doors Direct Limited | Extraterritorial | 2015 |
| Doqit Technologies Limited | Information & communication | 2017 |
| Double Barrel Photography Ltd | Professional & scientific | 2022 |
| Dougdrop Ltd | Transport & logistics | 2026 |
| Douglas Farms | Agriculture & fishing | 2009 |
| Douglas Hardware Ltd | Manufacturing | 2025 |
| Doulago Ltd | Wholesale & retail | 2025 |
| Dovecote Place (Newburn) Management Company Limited | Real estate | 2017 |
| Dowell Technical Services Limited | Construction | 2017 |
| Downland Marketing Limited | Agriculture & fishing | 1968 |
| Doxify Ltd | Other services | 2020 |
| Dpsm Properties Ltd | Real estate | 2016 |
| DPW Bodyworks Ltd | Wholesale & retail | 2019 |
| DR & HM Horsley Limited | Agriculture & fishing | 2003 |
| DR Ajay B Online Limited | Information & communication | 2022 |
| DR Grow Ltd | Wholesale & retail | 2017 |
| DR Surfacing Ltd | Construction | 2020 |
| DR Vbrown Healthcare Limited | Health & social care | 2025 |
| DR. ALI Aesthetics & Medical Services Limited | Health & social care | 2025 |
| Drainwise (Civils) Ltd | Wholesale & retail | 2018 |
| Drelincourt Developments Ltd | Real estate | 2019 |
| Drewcam Properties Limited | Real estate | 2024 |
| DRF Racing Limited | Arts & recreation | 2023 |
| Driftless Writing Ltd | Information & communication | 2026 |
| Drive Diva Car Sales Ltd | Wholesale & retail | 2026 |
| Driven by Kindness CIC | Wholesale & retail | 2025 |
| Driverlynk Limited | Administrative & support | 2025 |
| Drivethru Tax Limited | Professional & scientific | 2022 |
| Drogo Leisure Ltd | Hospitality | 2019 |
| Drovers Mount Management Company Limited | Households | 2021 |
| DRS Haulage Limited | Transport & logistics | 2016 |
| Drybeck Farm Limited | Extraterritorial | 2002 |
| Drydenmedia Ltd | Professional & scientific | 2021 |
| Drystone Digital Ltd | Information & communication | 2023 |
| DS Design Consultancy Limited | Information & communication | 2021 |
| DS Drainage & Property Maintenance Ltd | Administrative & support | 2026 |
| DS Engineering Services Limited | Professional & scientific | 2023 |
| DS Roofing Cumbria Limited | Construction | 2025 |
| DS Roofing North Cumbria Limited | Construction | 2019 |
| DSA Deliveries Ltd | Transport & logistics | 2021 |
| DSB Tools Limited | Wholesale & retail | 2017 |
| DSD Construction Limited | Construction | 1993 |
| DSG Inns Limited | Hospitality | 2024 |
| DSM Consult Limited | Professional & scientific | 2018 |
| Dstaveley Logistics Ltd | Transport & logistics | 2024 |
| DT Farms | Financial services | 2026 |
| DTC Motors Limited | Wholesale & retail | 2024 |
| Dtce Ltd | Construction | 2019 |
| Dtec Computers Ltd | Wholesale & retail | 2013 |
| Dual Fuel Solutions Ltd | Construction | 2013 |
| Dukespub Ltd | Hospitality | 2025 |
| Dumbarton 57 LLP | | 2013 |
| Dumfries Recycling Ltd | Water & waste | 2006 |
| Dunedin Dental Laboratory Ltd | Manufacturing | 2013 |
| Dunhams Court Letchworth LLP | | 2016 |
| Durham Travel Services Limited | Extraterritorial | 2011 |
| Dv&Sv Ltd | Wholesale & retail | 2025 |
| DVS Drive Ltd | Transport & logistics | 2016 |
| DW 2020 Limited | Financial services | 2019 |
| DWD Auto Repairs Ltd | Wholesale & retail | 2023 |
| DWH Groundworks Limited | Construction | 2021 |
| DWH Properties Cumbria Limited | Real estate | 2025 |
| DWT Rail Limited | Construction | 2013 |
| Dx-Ah Ltd | Other services | 2025 |
| Dykehead Dairies Limited | Agriculture & fishing | 2022 |
| Dylan Farish Car Sales Ltd | Wholesale & retail | 2023 |
| Dynamic Family Ltd | Health & social care | 2022 |
| Dynamic IT Business Services Ltd | Information & communication | 1999 |
| E & P Enterprises Limited | Hospitality | 2024 |
| E C Park & Sons Limited | Administrative & support | 2022 |
| E I Carpentry and Joinery Ltd | Construction | 2025 |
| E&M Cards and Gifts Limited | Wholesale & retail | 2018 |
| E&M Services (Northern) Ltd | Construction | 2022 |
| E-Procurement Limited | Professional & scientific | 2021 |
| E-Trails Limited | Wholesale & retail | 2021 |
| E. B. Road Surfacing Ltd | Construction | 2014 |
| E. C. M. (Vehicle Delivery Service) Limited | Transport & logistics | 1984 |
| E.M.S. Engineering Consultants Ltd | Professional & scientific | 2011 |
| EA Roofing (Cumbria) Limited | Construction | 2026 |
| Earthmovers Limited | Construction | 2017 |
| East Brownrigg Ltd | Construction | 2017 |
| Ebamed Limited | Information & communication | 2011 |
| Ebcb 1 Limited | Financial services | 2018 |