| Cairns Chase and Cairns Park (Stainburn) Management Company Limited | Households | 2014 |
| Calamae Ltd | Wholesale & retail | 2023 |
| Caldbeck Oddfellows Ltd | Hospitality | 2017 |
| Caldew Construction Ltd | Construction | 2022 |
| Caldew Court Developments Limited | Construction | 2015 |
| Caldew Holdings Ltd | Real estate | 2019 |
| Caldew Logistics Ltd | Transport & logistics | 2023 |
| Caldew Plumbing & Heating Contractors Limited | Construction | 2001 |
| Caledonian Consumer Finance Ltd | Financial services | 2010 |
| Caledonian Loans Limited | Financial services | 2015 |
| Calvert Norris Limited | Real estate | 2020 |
| Calwoods Property Limited | Real estate | 2026 |
| Camber Homes (Carlisle) Limited | Real estate | 2024 |
| Cambium Forestry Limited | Agriculture & fishing | 2015 |
| Cambridge Drive Management Company Limited | Households | 2013 |
| Camel Digital Limited | Professional & scientific | 2017 |
| Camelot Holiday Park Limited | Hospitality | 2015 |
| Cameron Occupational Safety and Health Ltd | Professional & scientific | 2024 |
| Camilla Lucinda Photography Limited | Professional & scientific | 2018 |
| Campbell Teaching Limited | Information & communication | 2020 |
| Camping at Cardewlees Ltd. | Hospitality | 2017 |
| Camtex Corporation Limited | Professional & scientific | 2001 |
| Camtex Fabrics Limited | Manufacturing | 1958 |
| Camy Cleaning, Ironing &Tailoring Alterations Ltd | Manufacturing | 2021 |
| Canal Court Management Limited | Households | 1989 |
| Candle Boys Ltd | Manufacturing | 2020 |
| Canmore Engineering Limited | Professional & scientific | 2008 |
| Cannon Couriers Ltd | Transport & logistics | 2025 |
| Cannon Gardens & Landscaping Ltd | Administrative & support | 2022 |
| Cannons Courier Ltd | Transport & logistics | 2026 |
| Cappacavella Leisure Limited | Hospitality | 2023 |
| CAPTAINWHITE247 Limited | Health & social care | 2025 |
| Captivitas Ltd | Wholesale & retail | 2020 |
| Car & Commercial (Carlisle) Limited | Wholesale & retail | 2012 |
| Cara Cormack Creative Limited | Professional & scientific | 2022 |
| Cara DAN Enterprises Limited | Wholesale & retail | 2011 |
| Caractacus Limited | Extraterritorial | 2016 |
| Caramaz Ltd | Wholesale & retail | 2025 |
| Carapart Limited | Wholesale & retail | 2009 |
| Carbon & Environment Solutions Limited | Professional & scientific | 2008 |
| Carbon Forests Limited | Agriculture & fishing | 2020 |
| Cardweb Limited | Professional & scientific | 2000 |
| Care Improvement Associates Ltd. | Professional & scientific | 2017 |
| Career Development Finance Limited | Financial services | 1995 |
| Career Finance 4 Trade Skills Limited | Financial services | 2007 |
| Carer Support West Cumbria Limited | Health & social care | 2007 |
| Caresure Limited | Health & social care | 2007 |
| Carigiet Cowen Limited | Real estate | 2002 |
| Carleton Sojourner Ltd | Information & communication | 2016 |
| Carlisle 1962 Limited | Construction | 2013 |
| Carlisle Abodes Ltd | Real estate | 2025 |
| Carlisle and District Model Engineering Society | Other services | 1996 |
| Carlisle and Eden Districts Citizens Advice Bureau | Professional & scientific | 2005 |
| Carlisle Auto Care Ltd | Wholesale & retail | 2022 |
| Carlisle Auto Repairs Limited | Wholesale & retail | 2008 |
| Carlisle Bargain Store Ltd | Wholesale & retail | 2025 |
| Carlisle Bathroom Centre Limited | Construction | 2018 |
| Carlisle Bathrooms Ltd | Construction | 2020 |
| Carlisle Cathedral Enterprises Limited | Wholesale & retail | 1982 |
| Carlisle City Control Ltd | Administrative & support | 2016 |
| Carlisle Community Help Community Interest Company | Hospitality | 2021 |
| Carlisle Computer Systems Limited | Wholesale & retail | 2023 |
| Carlisle Concrete Supplies Limited | Manufacturing | 2007 |
| Carlisle Developments Ltd | Construction | 2026 |
| Carlisle Eden Mind Limited | Other services | 2006 |
| Carlisle Electrical Ltd | Construction | 2025 |
| Carlisle Embroidery Limited | Wholesale & retail | 2003 |
| Carlisle Estates Company, Limited | Real estate | 1899 |
| Carlisle Estates Holdings Limited | Real estate | 2009 |
| Carlisle Fadecut Ltd | Other services | 2023 |
| Carlisle Family Law Limited | Extraterritorial | 2014 |
| Carlisle Flight Training Ltd | Education | 2004 |
| Carlisle Furniture Limited | Manufacturing | 2019 |
| Carlisle Garden Limited | Hospitality | 2019 |
| Carlisle Glass Limited | Construction | 1979 |
| Carlisle Global Ltd | Wholesale & retail | 2026 |
| Carlisle Golf Centre Limited | Wholesale & retail | 2002 |
| Carlisle Golf Club Limited | Arts & recreation | 2016 |
| Carlisle Golf Club Trading Limited | Hospitality | 2016 |
| Carlisle Green Room Club Limited | Arts & recreation | 1979 |
| Carlisle Gymnastics Club Limited | Education | 2016 |
| Carlisle Hair Loss Clinic Ltd | Other services | 2021 |
| Carlisle Healthcare Limited | Health & social care | 2016 |
| Carlisle Hockey Club | Arts & recreation | 2022 |
| Carlisle Joinery Limited | Construction | 2017 |
| Carlisle Key | Hospitality | 2003 |
| Carlisle Lake District Airport Limited | Transport & logistics | 2001 |
| Carlisle Lettings Limited | Real estate | 2022 |
| Carlisle Matters CIC | Administrative & support | 2024 |
| Carlisle Mencap Limited | Health & social care | 2005 |
| Carlisle NUMBER1 Fade Ltd | Other services | 2023 |
| Carlisle One World Centre | Other services | 2001 |
| Carlisle Plumbing and Heating Ltd | Construction | 2021 |
| Carlisle Property Care Limited | Construction | 2019 |
| Carlisle Property Maintenance Limited | Construction | 2026 |
| Carlisle Recycling Limited | Water & waste | 2007 |
| Carlisle Refrigeration (Holdings) Limited | Manufacturing | 2010 |
| Carlisle Refrigeration Limited | Manufacturing | 1984 |
| Carlisle Remapping Ltd | Wholesale & retail | 2026 |
| Carlisle Roofing Company Limited | Construction | 2024 |