| Scalearound Limited | Information & communication | 2023 |
| Scaleeup Ltd | Public administration | 2025 |
| Scaling Crms Ltd | Information & communication | 2026 |
| Scaling Founders UK Ltd | Information & communication | 2025 |
| Scaling With Scarcity Limited | Professional & scientific | 2023 |
| Scam Smart Ltd | Administrative & support | 2016 |
| Scammell Developments Limited | Wholesale & retail | 1999 |
| Scamsense Ltd | Information & communication | 2025 |
| SCAN4BABY Ltd | Health & social care | 2019 |
| Scanderson Roofing Ltd | Construction | 2024 |
| Scandic Designs Ltd | Wholesale & retail | 2018 |
| Scandimall Limited | Extraterritorial | 2022 |
| SCANMOBILITY115 Ltd | Wholesale & retail | 2020 |
| Scanvue Limited | Administrative & support | 2020 |
| Scap Solution Limited | Wholesale & retail | 2025 |
| Scapitalfx Ltd | Information & communication | 2026 |
| Scara Digital Ltd | Real estate | 2023 |
| Scaramantica Pizzeria Ltd | Hospitality | 2019 |
| Scarce Ltd | Wholesale & retail | 2026 |
| Scarlet Knight Hairdressing Limited | Other services | 2013 |
| Scarlett Foreign Ltd | Wholesale & retail | 2023 |
| Scarlett Stop and Drop Ltd | Transport & logistics | 2019 |
| Scatter Slots & Co Ltd | Wholesale & retail | 2020 |
| SCB Private Consultancy Ltd | Professional & scientific | 2019 |
| SCB Supply Chain Consultancy Ltd | Professional & scientific | 2017 |
| SCC Logistics Ltd | Transport & logistics | 2015 |
| Sccs Consultancy Ltd | Administrative & support | 2023 |
| Scds International Limited | Wholesale & retail | 2019 |
| Scene Landscaping Ltd | Administrative & support | 2023 |
| Scenetech Ltd | Information & communication | 2011 |
| Scenic F/X Construction Ltd | Manufacturing | 2022 |
| Scenic Standby Ltd | Information & communication | 2003 |
| Scenic Topco Limited | Other services | 2017 |
| Scent Cloud Limited | Manufacturing | 2016 |
| Scent Seller Limited | Wholesale & retail | 2019 |
| Scentology Ltd | Wholesale & retail | 2019 |
| Sceptor Ltd | Financial services | 2025 |
| SCF Auto Ltd | Professional & scientific | 2019 |
| Schanglen Capital Limited | Professional & scientific | 2025 |
| Schawatea International Limited | Information & communication | 2020 |
| Schema Therapy UK Ltd | Health & social care | 2025 |
| Schg Holdings Limited | Real estate | 2017 |
| Schmidt Bath Ltd | Construction | 2017 |
| Schnauzer Capital Management Ltd | Financial services | 2013 |
| Schnauzer Ltd | Construction | 2024 |
| Schneider Sonnenlicht Ltd | Other services | 2025 |
| Schnitzelland Ltd | Hospitality | 2020 |
| Schola Venditionis Ltd | Information & communication | 2025 |
| School Circle Ltd | Education | 2019 |
| School of Hard Knocks | Arts & recreation | 2011 |
| School of Islamic Beliefs Ltd | Administrative & support | 2025 |
| School Playing Fields Services Ltd | Administrative & support | 2010 |
| School Teacher Connect Limited | Administrative & support | 2019 |
| Schoolfriend Clubs Limited | Education | 2011 |
| Schoolhouse Burn Hydropower Ltd | Energy | 2020 |
| Schools Into Europe Ltd | Transport & logistics | 1998 |
| Schools Into Europe Travel Ltd | Administrative & support | 1989 |
| Schooner View Management Company Limited | Households | 1988 |
| Schooner Wharf Apartments RTM Company Ltd | Households | 2020 |
| Schoop Ltd | Information & communication | 2013 |
| Schway Limited | Agriculture & fishing | 2019 |
| SCI Green Innovations Ltd | Professional & scientific | 2016 |
| Sci-Protein Ltd | Wholesale & retail | 2022 |
| Scible Ltd | Information & communication | 2018 |
| Scidatarr Ltd | Financial services | 2022 |
| Science Clothing Ltd | Other services | 2014 |
| Science Made Simple Limited | Education | 2004 |
| Science Spot Services Ltd | Wholesale & retail | 2025 |
| Scienceposters Limited | Manufacturing | 2015 |
| Scientific and Computer Development SCD2 Ltd | Professional & scientific | 2022 |
| Scientific Goods and Services Ltd | Other services | 2020 |
| Scimitar Construction Consultancy Ltd | Professional & scientific | 2018 |
| Scimitar Homes (Cyncoed) Limited | Construction | 2018 |
| Scimitar Projects Limited | Construction | 2021 |
| Scissorhands HR Ltd | Administrative & support | 2019 |
| Scissorhands London Limited | Other services | 2016 |
| Scitechseries Publishing Ltd | Information & communication | 2022 |
| Sclmml Ltd | Professional & scientific | 2015 |
| SCM Products Ltd | Manufacturing | 2013 |
| SCM Property Ltd | Real estate | 2015 |
| Scoldanprism Limited | Information & communication | 2024 |
| Scolette Business PC | | 2019 |
| Sconestone Limited | Real estate | 2025 |
| Scoops Car Sales Ltd | Wholesale & retail | 2024 |
| Scoops Hand Car Wash Ltd | Administrative & support | 2024 |
| Scopepoint Ltd | Education | 2023 |
| Score Media & Public Relations Limited | Information & communication | 2006 |
| Scorpioai Ltd | Information & communication | 2023 |
| Scorpius Capital Ltd | Financial services | 2019 |
| Scotian Homes International Limited | Construction | 2008 |
| Scotpac - Scotia Pacific Limited | Wholesale & retail | 2017 |
| Scott (Dudley Hill) Limited | Manufacturing | 1926 |
| Scott David Holdings Limited | Financial services | 1983 |
| Scott Edwards Building Contractors Limited | Construction | 2019 |
| Scott GUY Ltd | Construction | 2018 |
| Scott OFF the Press Ltd | Manufacturing | 2024 |
| Scott PAY Ltd | Administrative & support | 2021 |
| Scott Prime Ltd | Wholesale & retail | 2025 |
| Scott Robert Limited Liability Partnership | | 2008 |
| Scott Services (Wales) Ltd | Other services | 2014 |