| Samkevjohnson Event Management Ltd | Hospitality | 2022 |
| Samm Essentials Ltd | Wholesale & retail | 2025 |
| Sammy House Ltd | Hospitality | 2019 |
| Samo Norway Limited | Extraterritorial | 2023 |
| Sampay Service Ltd | Other services | 2024 |
| Samphor Ltd | Wholesale & retail | 2014 |
| Sampson West Accountancy Limited | Professional & scientific | 2018 |
| Sampson West Ltd | Professional & scientific | 2009 |
| Samrow Beauty Ltd | Wholesale & retail | 2025 |
| Sams Traders Ltd | Transport & logistics | 2025 |
| Samsaf (Cardiff) Ltd | Hospitality | 2013 |
| Samsite Ltd | Hospitality | 2017 |
| Samson Structural Design Services Limited | Mining & quarrying | 2018 |
| Samtech Justine Ltd | Wholesale & retail | 2026 |
| Samtin Fashion Limited | Manufacturing | 2025 |
| Samu Elite Designs Limited | Wholesale & retail | 2025 |
| Samuel James PUB Co Ltd | Hospitality | 2015 |
| Samuel North Ltd | Professional & scientific | 2025 |
| Samuel Solutions Ltd | Real estate | 2018 |
| Samui Country Trading Co Ltd | Water & waste | 2021 |
| Samurai Holdings Limited | Financial services | 2024 |
| Samye Foundation Wales | Professional & scientific | 2006 |
| Samysam Limited | Professional & scientific | 2007 |
| SAN 24 IT Consultancy Ltd | Information & communication | 2020 |
| SAN Construction Ltd | Construction | 2013 |
| SAN Vito Limited | Real estate | 2005 |
| Sana Partners Ltd | Health & social care | 2021 |
| Sanaa Restaurant Ltd | Hospitality | 2026 |
| Sanara Life Solutions | Administrative & support | 2024 |
| Sanct Ltd | Construction | 2025 |
| Sanctuary Cafe Ltd | Hospitality | 2026 |
| Sanctuary Financial Ltd | Financial services | 2015 |
| Sanctuary Haven Ltd | Health & social care | 2017 |
| Sanctuary Technologies Limited | Professional & scientific | 2019 |
| Sand, Sea & Cities Ltd | Administrative & support | 2023 |
| Sandbank Enterprises Limited | Professional & scientific | 2018 |
| Sandbanks GP Ltd | Health & social care | 2025 |
| Sandbanks Properties Ltd. | Real estate | 2021 |
| Sandcastles Ltd | Real estate | 2018 |
| Sandeep Dhattarwal Ltd | Wholesale & retail | 2025 |
| Sanders and Sanders (Cardiff) Limited | Professional & scientific | 1987 |
| Sanders Design Associates Limited | Other services | 1995 |
| Sanders Product Design and Branding Ltd | Professional & scientific | 2019 |
| Sanderson's Removals & Storage Ltd | Transport & logistics | 2019 |
| Sandford Flooring Ltd | Manufacturing | 2018 |
| Sandgroper Limited | Wholesale & retail | 2016 |
| Sandhu & Randhawa Ltd | Hospitality | 2025 |
| Sandhu Taxi Service Limited | Transport & logistics | 2024 |
| Sandi IT Services Ltd | Information & communication | 2025 |
| Sandie Webshop Ltd | Information & communication | 2025 |
| Sandirate Limited | Administrative & support | 2019 |
| Sandiway Capital Limited | Real estate | 2017 |
| Sandkdroppy Ltd | Other services | 2024 |
| Sandmill Ltd | Construction | 2015 |
| Sandon Medical Aesthetic Clinic Ltd | Other services | 2021 |
| Sandor Magyar Ltd | Professional & scientific | 2020 |
| Sandora Ltd | Construction | 2018 |
| Sandra Andersson Limited | Extraterritorial | 2025 |
| Sandra Contracting UK Limited | Construction | 2016 |
| Sandra Mar.T.T Ltd | Wholesale & retail | 2019 |
| Sandrasnow Ltd | Professional & scientific | 2026 |
| Sandrock Group Co., Ltd | Administrative & support | 2024 |
| Sandrsi Ltd | Wholesale & retail | 2025 |
| Sands Hairdressing Limited | Other services | 2002 |
| Sandsound Ltd | Information & communication | 2014 |
| Sandstone Recruitment Group Limited | Administrative & support | 2018 |
| Sandusky Remills Holdings Limited | Professional & scientific | 2013 |
| Sandusky Remills Limited | Health & social care | 2006 |
| Sandwharf (RTM) Ltd | Households | 2009 |
| Sandwiches Bristol Ltd | Hospitality | 2026 |
| Sandwichescardiff Ltd | Hospitality | 2025 |
| Sandwick Close Maintenance Limited | Households | 1976 |
| Sanejjy Trading Ltd | Wholesale & retail | 2025 |
| Sanex Development Ltd | Information & communication | 2018 |
| Sanford Property Group Ltd | Administrative & support | 2017 |
| Sang Bite Ltd | Wholesale & retail | 2025 |
| Sangger Limited | Wholesale & retail | 2021 |
| Sangi Interiors Ltd | Wholesale & retail | 2026 |
| Sanif Ltd | Wholesale & retail | 2023 |
| Sanita Delivery Service Ltd | Transport & logistics | 2018 |
| Sanjiv Ltd | Wholesale & retail | 2024 |
| Sanli Food and Service Limited | Hospitality | 2023 |
| Sanli Kitchen Limited | Hospitality | 2025 |
| Sanli Technology Limited | Construction | 2023 |
| Sanmar Properties Limited | Real estate | 2023 |
| Sanmar Services Limited | Health & social care | 2016 |
| Sanmich Limited | Manufacturing | 2023 |
| Sanne Management Consultancy Limited | Professional & scientific | 2025 |
| Sanova Group Ltd | Manufacturing | 2025 |
| Sanrival Limited | Wholesale & retail | 2016 |
| Sansli Ltd | Wholesale & retail | 2024 |
| Santalaceae Ltd | Wholesale & retail | 2021 |
| Santapas Limited | Hospitality | 2023 |
| Santellica IT Consultants Limited | Information & communication | 2017 |
| Santhi Restaurant Limited | Hospitality | 2017 |
| Santhiya Health Care PVT Ltd | Health & social care | 2019 |
| Santis Capital Ltd | Real estate | 2024 |
| Santo Clothing Ltd | Wholesale & retail | 2021 |
| Santos Cardiff Limited | Wholesale & retail | 2024 |
| Santos Couture Ltd | Wholesale & retail | 2017 |