| Sacramento Consulting Group Ltd | Professional & scientific | 2023 |
| Sacred Druids Circle Ltd | Education | 2025 |
| Sacrifice NOW Limited | Wholesale & retail | 2019 |
| Sacrifice the Worldly Pleasure Ltd | Wholesale & retail | 2024 |
| Sacsam Limited | Information & communication | 2018 |
| Sada YAR Ltd | Wholesale & retail | 2025 |
| Sadaya Ltd | Real estate | 2021 |
| Sadaya Properties Ltd | Real estate | 2025 |
| Sadco Limited | Wholesale & retail | 2018 |
| Sade Group Limited | Wholesale & retail | 2021 |
| Sadek Aesthetic Ltd | Health & social care | 2020 |
| Sadem Construction Ltd | Construction | 2019 |
| Sadia a Consultancy Limited | Administrative & support | 2018 |
| Sadia Maqsood Ltd | Wholesale & retail | 2025 |
| Sadlers Hair & Beauty Salon Limited | Other services | 2023 |
| Sadni Ltd | Transport & logistics | 2019 |
| SAE Group Ltd | Professional & scientific | 2019 |
| SAE Property Developments Ltd | Households | 2022 |
| SAE Services Limited | Professional & scientific | 2019 |
| Saed House Limited | Hospitality | 2023 |
| Saeedlogistics Limited | Wholesale & retail | 2025 |
| Saen Mobility Ltd | Wholesale & retail | 2024 |
| Saerp Ltd | Information & communication | 2025 |
| Saesoe Holdings Ltd | Administrative & support | 2024 |
| Saesoe Ltd | Manufacturing | 2024 |
| SAF Graphics Develop Ltd | Professional & scientific | 2025 |
| Safa Halal Meat Limited | Wholesale & retail | 2026 |
| SAFA21 Food Ltd | Hospitality | 2025 |
| Safalta Ltd | Hospitality | 2024 |
| Safari Coalition Ltd | Information & communication | 2025 |
| Safe & Secure Access Ltd | Construction | 2017 |
| Safe & Secure Training Limited | Administrative & support | 2005 |
| Safe Alpha Squad Ltd | Construction | 2025 |
| Safe and Secure Automotive Limited | Wholesale & retail | 2025 |
| Safe Bridge Enterprise Limited | Wholesale & retail | 2022 |
| Safe Digital Company Ltd | Information & communication | 2025 |
| Safe Edge Scaffolding Services Ltd | Construction | 2024 |
| Safe Families for Children Wales | Health & social care | 2014 |
| Safe Holidays Trip Ltd | Wholesale & retail | 2024 |
| Safe Meet and Greet Limited | Transport & logistics | 2025 |
| Safe OIL and GAS Services Ltd | Mining & quarrying | 2025 |
| Safe Online Space Cymru CIC | Information & communication | 2024 |
| Safe Room Ltd | Real estate | 2020 |
| Safe Space Syndicate Ltd | Wholesale & retail | 2024 |
| Safe Surroundings (UK) Ltd | Professional & scientific | 2011 |
| Safe Surroundings(Testing) Limited | Professional & scientific | 2024 |
| Safe Test Wales 2019 Ltd | Professional & scientific | 2019 |
| Safe Tunnel Ltd | Other services | 2025 |
| SAFE2SCHOOL Ltd | Transport & logistics | 2025 |
| Safebasket Ltd | Wholesale & retail | 2025 |
| Safechain Limited | Administrative & support | 2010 |
| Safecontractor Limited | Information & communication | 2011 |
| Safegrid Consultancy Ltd | Information & communication | 2025 |
| Safeguard Electrical Limited | Construction | 2018 |
| Safeguarding Solutions Consultancy Ltd | Health & social care | 2024 |
| Safehaven Capital Ltd. | Financial services | 2017 |
| Safehaven South Wales Limited | Administrative & support | 2017 |
| Safehr Limited | Information & communication | 2013 |
| Safekeep Properties Ltd | Households | 2025 |
| SAFEN3T Ltd | Information & communication | 2019 |
| Safepath Leadership Ltd | Professional & scientific | 2013 |
| Safer England Ltd | Administrative & support | 2017 |
| Safer Wales | Other services | 1998 |
| Safesameday Couriers Ltd | Transport & logistics | 2018 |
| Safestream Digital Products Ltd | Information & communication | 2024 |
| Safestyle Security Services Limited | Administrative & support | 2001 |
| Safety Assured Security Services Ltd | Administrative & support | 2024 |
| Safety Committee for Safety Security Ltd | Administrative & support | 2019 |
| Safety Education UK Ltd | Information & communication | 2020 |
| Safety Educational Media UK Ltd | Administrative & support | 2018 |
| Safety First Contractors Ltd | Construction | 2025 |
| Safety First Plumbing & GAS Ltd | Construction | 2018 |
| Safety Risk Management Limited | Administrative & support | 2004 |
| Safety Solutions Training Limited | Administrative & support | 2016 |
| Safety Zone Security Ltd | Administrative & support | 2024 |
| Safewear Cardiff Limited | Wholesale & retail | 2009 |
| Safewills UK (Funeral Plans) Limited | Professional & scientific | 2019 |
| Safewills UK Limited | Professional & scientific | 2019 |
| Safeworkforce Limited | Professional & scientific | 1991 |
| Safezone Construction Ltd | Construction | 2017 |
| Saffron Beans Limited | Hospitality | 2025 |
| Saffron Cafe Limited | Hospitality | 2020 |
| Saffron Fire Ltd | Hospitality | 2025 |
| Saffys Vault Limited | Wholesale & retail | 2025 |
| Safira Builder Ltd | Construction | 2017 |
| Safivex Ltd | Wholesale & retail | 2025 |
| Safiyah Al-Rahman Ltd | Health & social care | 2025 |
| Safran Restaurant Ltd | Hospitality | 2016 |
| SAG Structural Engineering Services (PVT) Ltd | Wholesale & retail | 2018 |
| Saga Glob Limited | Professional & scientific | 2026 |
| Sagarmatha Properties Limited | Real estate | 2006 |
| Sage Against the Machine Ltd | Wholesale & retail | 2024 |
| Sage and Slate Ltd | Hospitality | 2025 |
| Sage CAP Trading Co., Ltd | Administrative & support | 2022 |
| Sage Deli Ltd | Hospitality | 2018 |
| Sage Hair Care (Salons) Limited | Other services | 2020 |
| Sage Hair Care Limited | Financial services | 2020 |
| Sage Property DVL Ltd | Real estate | 2025 |
| Sage Roberts Limited | Health & social care | 2017 |
| Sageluxe Recruiters Ltd | Administrative & support | 2020 |