| Cambridge Graphics Limited | Professional & scientific | 2005 |
| Cambridge Homes Limited | Real estate | 1984 |
| Cambridge House of Beauty Limited | Other services | 2002 |
| Cambridge Informatics Limited | Information & communication | 1997 |
| Cambridge IT Ltd | Information & communication | 2023 |
| Cambridge Medical Services LLP | | 2002 |
| Cambridge Micro Engineering Limited | Professional & scientific | 1988 |
| Cambridge Network Solutions Ltd | Information & communication | 2005 |
| Cambridge Patents Limited | Professional & scientific | 2003 |
| Cambridge Refrigeration Technology Limited | Professional & scientific | 2006 |
| Cambridge RF Limited | Information & communication | 2003 |
| Cambridge Technology Development Limited | Professional & scientific | 2002 |
| Cambridge Worktops Ltd | Construction | 2015 |
| Cambridgeshire Publishing Group Ltd | Information & communication | 2023 |
| Cambs Farms Growers Limited | Agriculture & fishing | 2005 |
| Cambs Recycling Limited | Water & waste | 2008 |
| Camdays Limited | Construction | 1977 |
| Cantabrigia Limited | Professional & scientific | 1947 |
| Cardboard Packaging Supplies Limited | Manufacturing | 1995 |
| Cathedral Property Developments (Peterborough) Limited | Construction | 2007 |
| CB Custom Coatings Ltd | Other services | 2013 |
| CB Self Storage Ltd | Transport & logistics | 2018 |
| Ccdc Services Limited | Information & communication | 1997 |
| Centre Thirty Three Young People's Counselling and Information Service | Health & social care | 1999 |
| Changeplan Limited | Professional & scientific | 1989 |
| Chapman Schofield Millennium Limited Partnership | | 2000 |
| Cherry Farms Limited | Agriculture & fishing | 2004 |
| Chesh TEC Limited | Administrative & support | 2005 |
| China National Petroleum Corporation Limited | Energy | 2017 |
| Churchill Residences II Limited | Construction | 1999 |
| City King Ltd | Information & communication | 2004 |
| Clark & Butcher Limited | Real estate | 1900 |
| Class O Productions Limited | Information & communication | 1999 |
| Cloverleaf Limited | Construction | 1999 |
| Co Productions Limited | Information & communication | 2005 |
| Cobra Engineering (UK) Limited | Manufacturing | 1999 |
| Cognoscenti Holdings Ltd | Real estate | 2021 |
| Colesworthy Grant Associates Limited | Professional & scientific | 1997 |
| Colin Flint Limited | Information & communication | 2003 |
| Commercial Trailers (Wisbech) Limited | | 1969 |
| Committed IT Solutions Ltd | Information & communication | 1999 |
| Compass Direct Limited | Real estate | 2003 |
| Competition Yard Limited | Extraterritorial | 2004 |
| Comtech (Glass) Limited | Wholesale & retail | 1991 |
| Congenia Limited | Real estate | 2001 |
| Connaught Wenlock Partnership Ltd | Information & communication | 1997 |
| Connelly Management Services Ltd | Administrative & support | 2023 |
| Construct 1 Services Limited | Construction | 2021 |
| Construction & Environmental Services Limited | Transport & logistics | 2004 |
| Coracle Analysis Limited | Public administration | 2004 |
| Corp Services Limited | Construction | 2005 |
| Corpus Inscriptionum Iranicarum | Information & communication | 1955 |
| Costcutter Little Downham Ltd | Wholesale & retail | 2010 |
| Custom Builders Cambridge Limited | Construction | 2004 |
| CWS Plumbing and Bathrooms Ltd | Construction | 2022 |
| Cyber Search Ltd | Administrative & support | 2020 |
| D & L Wines Ltd. | Wholesale & retail | 2006 |
| D Crawford Limited | Manufacturing | 2004 |
| D J Downes & Co Limited | Professional & scientific | 2002 |
| D S Industrial Roofing & Cladding Limited | Wholesale & retail | 2008 |
| D.B. & M.P. Barnard Limited | Manufacturing | 2003 |
| Dagless Holdings Limited | Professional & scientific | 1983 |
| Dalrod (UK) Limited | Water & waste | 1996 |
| Dartware Developments Ltd | Real estate | 2000 |
| Data Evailability Limited | Information & communication | 2005 |
| Datatalk (Statistical Solutions) Limited | Information & communication | 1996 |
| David Chittenden Properties Limited | Construction | 1976 |
| David Clary Ltd. | Professional & scientific | 2006 |
| David Jeffreys Limited | Professional & scientific | 2004 |
| Dawson of Stamford Limited | Wholesale & retail | 1984 |
| Dbshane Ltd | Wholesale & retail | 2024 |
| Ddtech Limited | Information & communication | 2008 |
| DE Luca Cucina Limited | Hospitality | 2005 |
| Debug Innovations Limited | Information & communication | 2004 |
| Delphi Design Ltd | Information & communication | 1997 |
| Delta Structures Limited | Construction | 2000 |
| Delta Systems (Wisbech) Limited | Manufacturing | 1996 |
| Demcom Asbestos Services Ltd | Administrative & support | 2020 |
| Demcom Demolition Limited | Administrative & support | 2023 |
| Demcom Limited | Administrative & support | 2015 |
| Dent Security Systems Limited | Administrative & support | 1988 |
| Desiderata Services Limited | Extraterritorial | 2005 |
| DHC Developments Limited | Real estate | 2003 |
| Diligenta Limited | Financial services | 2005 |
| Direct Developments Construction Ltd | Construction | 2023 |
| Donald Racey & Sons Limited | Agriculture & fishing | 1976 |
| Double Data Limited | Information & communication | 1992 |
| Drake Towage Limited | Construction | 1995 |
| Dreamvalley Productions Limited | Information & communication | 1997 |
| Ducketts Properties Limited | Real estate | 2007 |
| Duckworth and Kent (Precision Components) Limited | Manufacturing | 1975 |
| Dynamic Testing Limited | Information & communication | 2005 |
| E.W.Elphick & Sons,Limited | Wholesale & retail | 1947 |
| Early's 1669 Limited | Wholesale & retail | 2018 |
| Easy Apps Business Limited | Administrative & support | 2014 |
| EAT N' Bowl Enterprises Limited | Arts & recreation | 1996 |
| Eaton Tractors Limited | Manufacturing | 1976 |
| Ecad Electrical Drawing Services Ltd | Construction | 1998 |
| Ecoda Limited | Extraterritorial | 2006 |
| Economic Growth Management Ltd | Administrative & support | 2000 |