| Francis Thomas Properties Ltd | Real estate | 2018 |
| Franck Investments Limited | Real estate | 2020 |
| Frank and Jeran Tech Ltd | Administrative & support | 2018 |
| Franklin & BYE Construction Limited | Construction | 2012 |
| Franklin Make UP Ltd | Other services | 2019 |
| Frankswood Residents Association Limited | Households | 1986 |
| Fraser Anti-Static Techniques Limited | Manufacturing | 1991 |
| Fraser Brother Investment Ltd | Real estate | 2024 |
| Fraser Stannard Property Ltd | Construction | 2014 |
| Fraserwelsh Biotechnology Consulting Limited | Professional & scientific | 2025 |
| Fratelli Hair Cambridge Limited | Extraterritorial | 2018 |
| Fratelli Ladies & Mens Hair Salon Ltd | Other services | 2013 |
| Frazer Stannard Ltd | Manufacturing | 2014 |
| Frazer Stannard Property Ltd | Construction | 2014 |
| FRB Global Ltd | Professional & scientific | 2024 |
| Frear-Uk Limited | Information & communication | 2017 |
| Fred the Foot Limited | Health & social care | 2011 |
| Freddie Grubb Limited | Extraterritorial | 2011 |
| Frederic Smart & SON Limited | Wholesale & retail | 1966 |
| Frederic Smart Logistics Limited | Transport & logistics | 2025 |
| Frederic Smart Shipping Limited | Transport & logistics | 2020 |
| Frederic's Ltd | Hospitality | 2024 |
| Fredjon Limited | Professional & scientific | 2012 |
| Free Bird International Aviation Ltd | Manufacturing | 2023 |
| Free Food Van Ltd | Hospitality | 2022 |
| Free Future Trading Limited | Wholesale & retail | 2025 |
| Free Planet Network Limited | Information & communication | 2025 |
| Free VPN App Limited | Information & communication | 2023 |
| Freed Fencing Limited | Administrative & support | 2007 |
| Freedom Consultants Ltd | Other services | 2019 |
| Freedom Finance Europe Limited | Extraterritorial | 2022 |
| Freedom Living Group Limited | Extraterritorial | 2026 |
| FREEDOM26 Ltd | Wholesale & retail | 2026 |
| Freefall Gear Store Ltd | Arts & recreation | 2018 |
| Freehold Apps Ltd | Information & communication | 2025 |
| Freehold Properties 23 Limited | Real estate | 2005 |
| Freehold Properties 36 Limited | Real estate | 2006 |
| Freeland Rees Roberts (Holdings) Limited | Professional & scientific | 2015 |
| Freeland Rees Roberts Trustees Limited | Extraterritorial | 2018 |
| Freeyoursunday Limited | Information & communication | 2024 |
| Freire Composites Ltd | Manufacturing | 2022 |
| Frema Wholesale Ltd | Wholesale & retail | 2020 |
| French Dodd Associates Limited | Extraterritorial | 1995 |
| French Quarter Southampton (UK) Ltd | Real estate | 2022 |
| Fresh Bangla VEG Limited | Wholesale & retail | 2025 |
| Fresh CUT Cambridge Ltd | Other services | 2020 |
| Fresh Harvest Global and Partners Ltd | Wholesale & retail | 2024 |
| Fresh IP EP Limited | Professional & scientific | 2013 |
| Fresh Systems Limited | Information & communication | 1994 |
| Freshbreeze Solutions Limited | Financial services | 2024 |
| Freshwater Estates (Haverhill) Ltd | Construction | 2018 |
| Freshwater Estates (Mildenhall) Limited | Construction | 2009 |
| Freshwater Estates (Newmarket) Ltd | Construction | 2018 |
| FRF Holdings Limited | Professional & scientific | 2017 |
| Friars Mead Management Co. Limited | Households | 1987 |
| Fridice IT Systems Limited | Information & communication | 2008 |
| Friends Care Limited | Health & social care | 2020 |
| Friends Five Star Beauty Ltd | Other services | 2018 |
| Friends Five Star Hairdressing Ltd. | Other services | 2011 |
| Friends of Cherry Hinton Primary School Ltd | Education | 2024 |
| Friends of Gondwana Rainforest | Arts & recreation | 2011 |
| Friends of RMC Cambridge CIC | Other services | 2025 |
| Frod Consulting Limited | Professional & scientific | 2021 |
| Frodo Motorsport Ltd | Manufacturing | 2025 |
| Frog & Fish Ltd | Professional & scientific | 2026 |
| Frog Software Training Limited | Information & communication | 1991 |
| Frogs Parquet Limited | Extraterritorial | 2017 |
| From and to Ltd | Professional & scientific | 2019 |
| From the Ground UP Productions Ltd | Information & communication | 2025 |
| Front Bench Games Ltd | Information & communication | 2026 |
| Front Foot Creative Limited | Professional & scientific | 2021 |
| Frontdesk Master Ltd | Information & communication | 2012 |
| Fronteira Ltd | Health & social care | 2023 |
| Frontier Design Automation Ltd | Extraterritorial | 2012 |
| Frontier Developments PLC | Information & communication | 1994 |
| Frontier Games Limited | Information & communication | 2020 |
| Frontier Smart Technologies Limited | Manufacturing | 2001 |
| Frontline Express Ltd | Transport & logistics | 2020 |
| Froswick Limited | Real estate | 2023 |
| Frow World Travel Ltd | Administrative & support | 2023 |
| Frozen Tomato Events Ltd | Arts & recreation | 2013 |
| FRY Medical Communications Ltd | Professional & scientific | 2011 |
| FRY Scales LLP | | 2024 |
| Fry's Catering Ltd | Hospitality | 2025 |
| Fryers Court (Swavesey) Limited | Households | 1988 |
| FS Goldsco Steel Co., Ltd | Wholesale & retail | 2021 |
| FSC Logistics Co., Ltd | Wholesale & retail | 2023 |
| FSG Africa Ltd | Manufacturing | 2017 |
| FTO Property Investment Limited | Real estate | 2023 |
| Fu's Subcutaneous Needling Association of Europe | Health & social care | 2018 |
| Fudu Walk 1 Limited | Professional & scientific | 2021 |
| Fufu QIN UK Ltd | Manufacturing | 2024 |
| Fujia International Limited | Extraterritorial | 2012 |
| Fujian Yuxing BAG Co., Ltd | Wholesale & retail | 2026 |
| Fukc Ltd | Wholesale & retail | 2022 |
| Fuku Sushi Limited | Hospitality | 2026 |
| Fulbourn Building FED Ltd | Construction | 2024 |
| Fulbourn Car Park Valeting Services Limited | Other services | 2006 |
| Fulbourn Kebab and Pizza Ltd | Hospitality | 2025 |
| Fulbourn Kebab Ltd | Hospitality | 2023 |