| Cambridge Science Centre | Education | 2012 |
| Cambridge Science Enterprises Limited | Arts & recreation | 2011 |
| Cambridge Scienchats Ltd | Education | 2023 |
| Cambridge Scientific Publishers Limited | Information & communication | 2004 |
| Cambridge Scientifix Ltd | Professional & scientific | 2024 |
| Cambridge Seamless Gutters Limited | Construction | 2014 |
| Cambridge Second Opinion Ltd | Professional & scientific | 2024 |
| Cambridge Security Consultants Ltd | Professional & scientific | 2020 |
| Cambridge Self Service Storage Limited | Extraterritorial | 2004 |
| Cambridge Seminars College Limited | Education | 2012 |
| Cambridge Serologicals Limited | Health & social care | 1994 |
| Cambridge Service Group Limited | Water & waste | 2024 |
| Cambridge Services Limited | Information & communication | 2025 |
| Cambridge Share Schemes Centre Limited | Professional & scientific | 2010 |
| Cambridge Shirt Company Ltd | Wholesale & retail | 1995 |
| Cambridge Shutong Education Limited | Education | 2017 |
| Cambridge Silicon AGE Centre for Innovation Ltd | Professional & scientific | 2015 |
| Cambridge Silicon Radio Holdings Limited | Financial services | 2011 |
| Cambridge Sinfonietta Productions Limited | Arts & recreation | 2026 |
| Cambridge Skills Hub Ltd | Education | 2026 |
| Cambridge Skin Clinic Limited | Health & social care | 2024 |
| Cambridge Skip Hire Limited | Water & waste | 2022 |
| Cambridge Skylights Limited | Wholesale & retail | 2021 |
| Cambridge Smart Plastics Limited | Manufacturing | 2019 |
| Cambridge Smiles Ltd | Health & social care | 2016 |
| Cambridge SMP Company Ltd | Other services | 2025 |
| Cambridge Software Engineering Ltd | Information & communication | 2014 |
| Cambridge Software Solutions Limited | Information & communication | 1997 |
| Cambridge Solar Environmental Solutions Limited | Professional & scientific | 2012 |
| Cambridge Sound Technologies UK Limited | Manufacturing | 2015 |
| Cambridge Sovereign Ltd | Administrative & support | 2022 |
| Cambridge Spanish Centre Ltd | Education | 2018 |
| Cambridge Spark Limited | Education | 2016 |
| Cambridge Spinal Column Limited | Health & social care | 2014 |
| Cambridge Spine Limited | Health & social care | 2021 |
| Cambridge Spire Ltd | Education | 2025 |
| Cambridge Sport Lakes Trading Limited | Arts & recreation | 2007 |
| Cambridge Sport Lakes Trust | Arts & recreation | 1994 |
| Cambridge Sports Medicine Centre Ltd | Health & social care | 2023 |
| Cambridge Star College Ltd | Education | 2019 |
| Cambridge Steiner School Project | Education | 1993 |
| Cambridge Stock Exchange Project Ltd | Financial services | 2024 |
| Cambridge Stoke Education Limited | Education | 2016 |
| Cambridge Stove Installations Limited | Construction | 2015 |
| Cambridge Stoves Ltd | Construction | 2012 |
| Cambridge Strategies (Consulting) Limited | Education | 2004 |
| Cambridge Strategy Centre Ltd | Professional & scientific | 2010 |
| Cambridge Strategy Consulting Group Ltd | Professional & scientific | 2026 |
| Cambridge Strategy Group Ltd | Professional & scientific | 2012 |
| Cambridge Structures (Stairs) Limited | Wholesale & retail | 1970 |
| Cambridge Student Experience Ltd | Administrative & support | 2015 |
| Cambridge Students' Union | Other services | 2020 |
| Cambridge Studies Ltd | Education | 2017 |
| Cambridge Studio Limited | Information & communication | 2019 |
| Cambridge Study Ltd | Administrative & support | 2013 |
| Cambridge Support & Services Limited | Real estate | 2025 |
| Cambridge Surgical Models Ltd | Manufacturing | 2023 |
| Cambridge Surgical Practice Ltd | Education | 2022 |
| Cambridge Sustainability Initiative Limited | Professional & scientific | 2023 |
| Cambridge Sustainability Limited | Education | 2016 |
| Cambridge Sustainable Food C.I.C. | Professional & scientific | 2018 |
| Cambridge Sustainable Technologies Research and Development Centre Limited | Professional & scientific | 2022 |
| Cambridge Sustainable Technology Solutions Ltd | Manufacturing | 2023 |
| Cambridge Swing Dance C.I.C. | Education | 2017 |
| Cambridge Systems Limited | Information & communication | 2017 |
| Cambridge Talent Academy Limited | Arts & recreation | 2018 |
| Cambridge Tales Ltd | Arts & recreation | 2018 |
| Cambridge Tandoori Ltd | Hospitality | 2025 |
| Cambridge Tax and Accounting Limited | Professional & scientific | 2023 |
| Cambridge Taxis Ltd | Transport & logistics | 2019 |
| Cambridge Teacher Development Ltd | Education | 2025 |
| Cambridge Tech Ltd | Manufacturing | 2013 |
| Cambridge Tech Week Ltd | Administrative & support | 2021 |
| Cambridge Technical Marketing Ltd | Professional & scientific | 2022 |
| Cambridge Technology Capital Limited | Professional & scientific | 2018 |
| Cambridge Technology Consultants Limited | Information & communication | 2003 |
| Cambridge Technology Group Limited | Professional & scientific | 1992 |
| Cambridge Technology Innovation Centre Ltd | Information & communication | 2019 |
| Cambridge Techworks Limited | Information & communication | 2014 |
| Cambridge Teckhno Limited | Information & communication | 2025 |
| Cambridge Tele.Com Limited | Information & communication | 2000 |
| Cambridge Telecommunications Ltd., | Information & communication | 1988 |
| Cambridge Text Education Ltd | Education | 2016 |
| Cambridge Theatre Trust | Arts & recreation | 2018 |
| Cambridge Therapy Centre Ltd | Health & social care | 2017 |
| Cambridge Therapy Collective Ltd | Health & social care | 2026 |
| Cambridge Therapy Rooms Limited | Health & social care | 2024 |
| Cambridge Think Tank Ltd | Education | 2022 |
| Cambridge Thinking Ltd | Professional & scientific | 2015 |
| Cambridge Tileworks Limited | Construction | 2009 |
| Cambridge Touch Technologies Ltd | Manufacturing | 2012 |
| Cambridge Traditional Products Limited | Manufacturing | 2003 |
| Cambridge Trainers Limited | Professional & scientific | 2002 |
| Cambridge Training Academy Ltd | Education | 2013 |
| Cambridge Training Associates Ltd | Professional & scientific | 2017 |
| Cambridge Transfer Service Ltd | Transport & logistics | 2023 |
| Cambridge Transformation Labs Ltd | Professional & scientific | 2023 |
| Cambridge Transformation Research Ltd | Professional & scientific | 2025 |
| Cambridge Turkish Barber Ltd | Other services | 2021 |
| Cambridge Turkish Grill Ltd | Hospitality | 2026 |