| Cambridge Cyber Limited | Information & communication | 2016 |
| Cambridge Cycle Company Ltd | Wholesale & retail | 2021 |
| Cambridge Cyrenians Limited | Hospitality | 1970 |
| Cambridge Dance Studios Limited | Arts & recreation | 2015 |
| Cambridge Data Engineering Limited | Information & communication | 2019 |
| Cambridge Data Innovation Limited | Information & communication | 2022 |
| Cambridge Data Limited | Professional & scientific | 2013 |
| Cambridge Data Recovery Ltd | Information & communication | 2008 |
| Cambridge Database Technologies Limited | Information & communication | 1987 |
| Cambridge Day Tours- Students LED Limited | Administrative & support | 2025 |
| Cambridge Decor Ltd | Construction | 2025 |
| Cambridge Deliveries Limited | Manufacturing | 2021 |
| Cambridge Dental Ceramics Limited | Health & social care | 2014 |
| Cambridge Dental Clinic Limited | Health & social care | 2024 |
| Cambridge Dental Studio Limited | Health & social care | 2019 |
| Cambridge Derm Consulting Ltd | Health & social care | 2025 |
| Cambridge Design Limited | Arts & recreation | 1987 |
| Cambridge Design Partnership Limited | Professional & scientific | 2009 |
| Cambridge Design Partnership LLP | | 2009 |
| Cambridge Design Technology Limited | Professional & scientific | 2015 |
| Cambridge Development Partners Ltd | Professional & scientific | 2023 |
| Cambridge Developments Ltd | Construction | 2021 |
| Cambridge Devices Limited | Professional & scientific | 1991 |
| Cambridge Dial a Ride Limited | Transport & logistics | 1996 |
| Cambridge Diamond Drilling Limited | Construction | 2012 |
| Cambridge Dielectrix Ltd | Manufacturing | 2026 |
| Cambridge Digital Consultancy Limited | Manufacturing | 2017 |
| Cambridge Digital Health Limited | Information & communication | 2016 |
| Cambridge Digital Limited | Information & communication | 2007 |
| Cambridge Digital Radio Limited | Information & communication | 2020 |
| Cambridge Dine Ltd | Hospitality | 2022 |
| Cambridge Direct Tree Seeding Limited | Construction | 2003 |
| Cambridge Discount Electrical Limited | Wholesale & retail | 1979 |
| Cambridge Discount Heating and Plumbing Limited | Professional & scientific | 2012 |
| Cambridge Discovery Consulting Ltd | Extraterritorial | 2022 |
| Cambridge Distillery Ltd | Manufacturing | 2011 |
| Cambridge Doctors Ltd | Health & social care | 2015 |
| Cambridge Document Solutions Limited | Manufacturing | 2026 |
| Cambridge Dog Services Ltd | Other services | 2020 |
| Cambridge Dongfang Dahua Heritage Foundation | Education | 2025 |
| Cambridge DR Aesthetics Ltd | Health & social care | 2024 |
| Cambridge Driveway Specialists Ltd | Construction | 2026 |
| Cambridge Driving Academy Ltd | Education | 2025 |
| Cambridge Driving Hub Ltd | Education | 2025 |
| Cambridge Driving Instructors Ltd | Education | 2025 |
| Cambridge Driving School Ltd | Education | 2024 |
| Cambridge Drug Development Consulting (Cddc) Limited | Professional & scientific | 2024 |
| Cambridge Dutchbikes Ltd | Wholesale & retail | 2009 |
| Cambridge EAL Ltd | Education | 2023 |
| Cambridge EAP Ltd | Education | 2013 |
| Cambridge Ecology Limited | Professional & scientific | 2007 |
| Cambridge Econometrics Limited | Professional & scientific | 1985 |
| Cambridge Economics Ltd | Professional & scientific | 2014 |
| Cambridge Editorial and Writing Ltd | Information & communication | 2019 |
| Cambridge Edtech Ltd | Professional & scientific | 2019 |
| Cambridge EDU Centre Ltd | Education | 2011 |
| Cambridge Education and Communication Center Limited | Information & communication | 2024 |
| Cambridge Education and Development Trust | Education | 2017 |
| Cambridge Education Consultancy Limited | Education | 2016 |
| Cambridge Education Consultant Ltd | Administrative & support | 2009 |
| Cambridge Education Development Centre Ltd | Professional & scientific | 2023 |
| Cambridge Education Exchange Centre Ltd | Information & communication | 2015 |
| Cambridge Education Group Limited | Professional & scientific | 2006 |
| Cambridge Education International Centre Ltd | Education | 2013 |
| Cambridge Education Technology Limited | Real estate | 2017 |
| Cambridge Educational Consultants Limited | Education | 2016 |
| Cambridge Educational Horizons Limited | Professional & scientific | 2011 |
| Cambridge Educational Opportunities CIC | Education | 2025 |
| Cambridge Eduvert Consulting Ltd | Education | 2020 |
| Cambridge Electric Ltd | Manufacturing | 2025 |
| Cambridge Electrical & Data Services Ltd | Construction | 2011 |
| Cambridge Electrical & Electronics Ltd | Construction | 2015 |
| Cambridge Electrical Design Ltd | Professional & scientific | 2025 |
| Cambridge Electrical Safety Testing Ltd | Construction | 2025 |
| Cambridge Electrical Services Ltd | Construction | 2009 |
| Cambridge Electromagnetic Technology Ltd | Wholesale & retail | 2019 |
| Cambridge Electron Beam Limited | Manufacturing | 2011 |
| Cambridge Electronic Design Limited | Manufacturing | 1970 |
| Cambridge Electronic Industries Limited | Manufacturing | 1987 |
| Cambridge Electronic Solutions Limited | Professional & scientific | 2012 |
| Cambridge Elite Business Limited | Real estate | 2022 |
| Cambridge Embedded Solutions Limited | Information & communication | 2006 |
| Cambridge Embroidery Ltd | Manufacturing | 2018 |
| Cambridge Emotions LAB Ltd | Professional & scientific | 2020 |
| Cambridge Empress Ltd | Hospitality | 2021 |
| Cambridge Endocare Ltd | Health & social care | 2020 |
| Cambridge Endurance Ltd | Education | 2019 |
| Cambridge Energetics Ltd | Professional & scientific | 2026 |
| Cambridge Energy Group Ltd | Administrative & support | 2016 |
| Cambridge Energy Limited | Manufacturing | 2015 |
| Cambridge Energy Solutions Ltd | Wholesale & retail | 2014 |
| Cambridge Engineering and Research Limited | Professional & scientific | 2010 |
| Cambridge Engineering Ltd | Professional & scientific | 2015 |
| Cambridge English Class Limited | Education | 2013 |
| Cambridge English Language Society | Education | 2016 |
| Cambridge ENT Consulting Limited | Health & social care | 2020 |
| Cambridge Enterprise Capital Limited | Administrative & support | 2012 |
| Cambridge Enterprise Limited | Professional & scientific | 1972 |
| Cambridge Environmental and Biotechnology Innovations Ltd | Professional & scientific | 2020 |
| Cambridge Environmental Consulting Limited | Professional & scientific | 2013 |