| Urgent Plumbing & Drainage Ltd | Construction | 2025 |
| Urology Expert Witness Limited | Health & social care | 2018 |
| Uroosa Trading Company Ltd | Extraterritorial | 2025 |
| Urriarra Ltd | Professional & scientific | 2010 |
| URS Barber Limited | Other services | 2026 |
| URU International Ltd | Information & communication | 2024 |
| Uruba Ltd | Wholesale & retail | 2025 |
| Urumqi Limited | Construction | 2024 |
| Urumqi Private Hire Limited | Transport & logistics | 2025 |
| US Comanzhuo Shares Co., Ltd | Mining & quarrying | 2025 |
| US Global Trade Limited | Wholesale & retail | 2023 |
| USA Smith Electrical Technology Co., Ltd | Extraterritorial | 2022 |
| USA Tiger-S Product Co., Ltd | Wholesale & retail | 2024 |
| Usability Nation Ltd | Professional & scientific | 2024 |
| USH Holdings Limited | Households | 2026 |
| Usha Consultancy Private Limited | Health & social care | 2020 |
| Usman Khandekar Limited | Wholesale & retail | 2025 |
| Usmile Medicine Limited | Manufacturing | 2023 |
| Usque in Crastinum Limited | Real estate | 2021 |
| Utility Energy Solutions Limited | Information & communication | 2010 |
| Utilityreg Ltd | Professional & scientific | 2025 |
| Utopian World of Sandwiches Ltd | Information & communication | 2011 |
| UTS Cambridge | Education | 2013 |
| Utsi Electronics Limited | Manufacturing | 2000 |
| UV Bonding Limited | Wholesale & retail | 2019 |
| UV Property Holdings Limited | Real estate | 2026 |
| UV Software Limited | Information & communication | 2020 |
| Uvdefence Limited | Administrative & support | 2020 |
| UVW Properties Ltd | Real estate | 2015 |
| UWE International Limited | Wholesale & retail | 2024 |
| UX Builders Limited | Information & communication | 2017 |
| UX Doctor Ltd | Information & communication | 2015 |
| UX Research Consulting Ltd | Information & communication | 2019 |
| UXD Limited | Information & communication | 2019 |
| Uxistential Ltd | Information & communication | 2025 |
| Uxixd Ltd | Information & communication | 2023 |
| V & a Aspire Cambridge Limited | Health & social care | 2020 |
| V & E Tyre Recycling Ltd | Manufacturing | 2022 |
| V & S (NO 14) Limited | Households | 1989 |
| V & V (Camb) Limited | Real estate | 2019 |
| V & V Care Limited | Health & social care | 2016 |
| V & V Real Estate Ltd | Real estate | 2021 |
| V &E Tyres Ltd | Other services | 2022 |
| V Chain International Trading Co., Limited | Professional & scientific | 2013 |
| V G N Construction Limited | Construction | 2019 |
| V K Properties Ltd | Real estate | 2000 |
| V Ltd | Extraterritorial | 2022 |
| V R Digitech Ltd | Information & communication | 2008 |
| V Shed Developments Ltd | Extraterritorial | 2022 |
| V Watch Limited | Administrative & support | 2025 |
| V&A Gaming Lounge Limited | Arts & recreation | 2025 |
| V&B Cleaning Solutions Ltd | Administrative & support | 2025 |
| V&E Car Valeting Services Limited | Other services | 2017 |
| V&E Shawarma Food Ltd | Hospitality | 2023 |
| V-Auth Limited | Information & communication | 2013 |
| V-Dairy (UK) Limited | Financial services | 2022 |
| V-Rex Ltd | Manufacturing | 2017 |
| V.O.Helico Ltd | Manufacturing | 2024 |
| V.U.K. Holdings Limited | Real estate | 1954 |
| V4-I Ltd | Real estate | 2024 |
| V99 Ltd | Professional & scientific | 2013 |
| VA Collect Ltd | Construction | 2026 |
| VA Investments Ltd | Real estate | 2021 |
| Vaainaavi Brothers PVT Ltd | Wholesale & retail | 2026 |
| Vacance Larmet Limited | Administrative & support | 2001 |
| Vacbits Ltd | Manufacturing | 2022 |
| Vactpoon Limited | Real estate | 1975 |
| Vagus Health Ltd | Manufacturing | 2017 |
| VAI Building Services Limited | Construction | 2024 |
| Vaishali Consultancy Limited | Information & communication | 2011 |
| Vakili Research Ltd | Information & communication | 2026 |
| Valdi Limited | Manufacturing | 2009 |
| Vale Imaging Consultancy Solutions Ltd | Professional & scientific | 2019 |
| Valentin&Simona Ltd | Manufacturing | 2024 |
| Valentine Conveyancers Limited | Professional & scientific | 2007 |
| Valentine INT Limited | Agriculture & fishing | 2014 |
| VALENTINILIE1984 Ltd | Manufacturing | 2023 |
| Valentinosound Ltd | Arts & recreation | 2025 |
| Valentis Holdings Ltd | Financial services | 2025 |
| Valesbiz Tax & Advisory Ltd | Professional & scientific | 2018 |
| Valiant IT Services Ltd | Information & communication | 2024 |
| Validation Solutions Ltd | Professional & scientific | 2025 |
| Valipharma Limited | Professional & scientific | 2004 |
| Valirx Bioinnovation Limited | Professional & scientific | 2006 |
| Valiseek Ltd | Professional & scientific | 2013 |
| Valisrc Limited | Wholesale & retail | 2009 |
| Valkyrie Airsoft Ltd | Wholesale & retail | 2020 |
| Valluga Ltd. | Other services | 2010 |
| Valpitcnc Ltd | Manufacturing | 2025 |
| Valtec Ltd | Professional & scientific | 2019 |
| Valtrans 681 Ltd | Transport & logistics | 2019 |
| Valuation Consultants Advisory Limited | Professional & scientific | 2023 |
| Valuation Consultants Limited | Professional & scientific | 2018 |
| Value Bazaar Ltd | Wholesale & retail | 2025 |
| Value in Enterprise Limited | Professional & scientific | 2006 |
| Value Realisation Solutions Ltd | Professional & scientific | 2023 |
| Value Resilience Advisory Limited | Professional & scientific | 2022 |
| Valytic Consulting Limited | Professional & scientific | 2019 |
| Vanadate Ltd | Professional & scientific | 2022 |
| Vanda Research Ltd | Financial services | 2016 |