| Skygazer Labs Ltd | Information & communication | 2010 |
| Skylark Learning Limited | Information & communication | 2013 |
| Skylight Architecture Ltd | Construction | 2021 |
| Skyline Luge Sheffield Limited | Arts & recreation | 2018 |
| Skylines Cabin Interiors Ltd | Manufacturing | 2019 |
| Skymond Limited | Construction | 1980 |
| Skypilot Ltd | Transport & logistics | 2023 |
| Skyroom London Limited | Financial services | 2018 |
| Skystoop Limited | Professional & scientific | 2025 |
| Skytech Cambridge Ltd | Professional & scientific | 2022 |
| Skywash Drones Limited | Financial services | 2025 |
| Skyways Solutions Ltd | Manufacturing | 2026 |
| Skyweb Workforce UK Ltd | Other services | 2023 |
| SL Aviation Ltd | Manufacturing | 2024 |
| SL Properties Cambridge Limited | Real estate | 2018 |
| SL Security Consultants Ltd | Administrative & support | 2021 |
| Slade Farm Ltd | Agriculture & fishing | 2002 |
| Sladedesign(Uk) Limited | Professional & scientific | 2017 |
| Slavec. Ltd | Transport & logistics | 2014 |
| Slaw Zapora Aviation Ltd | Manufacturing | 2025 |
| SLC PUB Co Limited | Hospitality | 2022 |
| SLC Work Placement Services C.I.C. | Information & communication | 2016 |
| SLD International Limited | Wholesale & retail | 2026 |
| Sleep Thief Limited | Manufacturing | 2017 |
| Sleeping Software Limited | Information & communication | 2005 |
| Sleepspaces Ltd | Real estate | 2024 |
| Sleeptech Co., Limited | Manufacturing | 2025 |
| Slepe Communications Limited | Information & communication | 2006 |
| SLG (Services) Ltd | Education | 2013 |
| Slipstream BIO Ltd | Professional & scientific | 2026 |
| SLJ Trade Ltd | Wholesale & retail | 2025 |
| SLN Ltd | Real estate | 2017 |
| SLN91 Ltd | Real estate | 2019 |
| SLN93 Ltd | Real estate | 2022 |
| SLN94 Ltd | Real estate | 2025 |
| SLT Light Source Technology Co., Ltd | Manufacturing | 2021 |
| SLW International Limited | Wholesale & retail | 2026 |
| SLW Property Solutions Limited | Real estate | 2025 |
| SLY Software Ltd | Information & communication | 2019 |
| Slysnap Limited | Information & communication | 2015 |
| SM Trading Services Ltd | Professional & scientific | 2015 |
| SM29 Retail Ltd | Wholesale & retail | 2022 |
| SMA Construction Cambridge Limited | Construction | 2018 |
| SMA Sports Ltd | Arts & recreation | 2019 |
| Smaa Fore Ltd | Real estate | 2017 |
| Smacznego Ltd | Hospitality | 2023 |
| Smacznego PL. Ltd | Hospitality | 2026 |
| Small and Green Ltd | Wholesale & retail | 2021 |
| Small Books Limited | Professional & scientific | 2008 |
| Small Ecology Limited | Administrative & support | 2019 |
| Small Radish Tutoring Ltd | Education | 2025 |
| Smalley Enterprises Limited | Wholesale & retail | 2025 |
| Smarks(Uk) PVT Ltd | Hospitality | 2021 |
| Smart (GZ) International Trading Ltd | Wholesale & retail | 2020 |
| Smart Alarms Limited | Construction | 2024 |
| Smart Arrow Agency Ltd | Health & social care | 2025 |
| Smart Astra Solutions Services Ltd | Transport & logistics | 2023 |
| Smart Camel Science Technology Co., Ltd | Extraterritorial | 2013 |
| Smart Cleaning Cambridge Ltd | Administrative & support | 2015 |
| Smart Component Technologies Limited | Manufacturing | 2011 |
| Smart Drivers Limited | Transport & logistics | 2015 |
| Smart Fare Taxi Ltd | Transport & logistics | 2025 |
| Smart Infrastructure Solutions Limited | Extraterritorial | 2015 |
| Smart OWL Software Limited | Information & communication | 2008 |
| Smart Payments Forum Limited | Other services | 2005 |
| Smart Resource Solutions Limited | Professional & scientific | 2013 |
| Smart Service Limited | Other services | 2009 |
| Smart-Ntd Scientific Solutions Ltd | Professional & scientific | 2025 |
| Smartbell Ltd | Agriculture & fishing | 2016 |
| Smartbourne Property Management Limited | Households | 1983 |
| Smarter Click Technology Holdings Limited | Financial services | 2020 |
| Smarter Data Solutions Ltd | Information & communication | 2021 |
| Smarter Sums Limited | Professional & scientific | 2014 |
| Smartex Group Limited | Other services | 2004 |
| Smartex Limited | Other services | 1992 |
| Smartfinancials Limited | Professional & scientific | 2018 |
| Smartinfosearch Limited | Information & communication | 2004 |
| Smartkidz Play and Learn Limited | Education | 2015 |
| Smartmetrics Limited | Information & communication | 2023 |
| Smartphone Port Ltd | Wholesale & retail | 2021 |
| Smartplumb Limited | Construction | 2003 |
| Smartresearchhr Ltd | Professional & scientific | 2013 |
| Smartstart Solutions Limited | Construction | 2021 |
| Smartvault Holdings Limited | Financial services | 2023 |
| Smartvault Software Limited | Information & communication | 2023 |
| Smartway Cleaning Ltd | Administrative & support | 2025 |
| Smasheries Ltd | Wholesale & retail | 2025 |
| SMB Mental Health Ltd | Health & social care | 2024 |
| SMB New Homes Limited | Construction | 2023 |
| SMB Ventures Limited | Real estate | 2017 |
| SMC Aerospace Ltd | Manufacturing | 2023 |
| SMC Pharma Services Ltd | Professional & scientific | 2016 |
| Smero Group Ltd | Wholesale & retail | 2024 |
| SMG Regulatory Services Limited | Professional & scientific | 2004 |
| SMG Topco Limited | Manufacturing | 2021 |
| Smida (Germany) International Holdings Limited | Wholesale & retail | 2024 |
| Smilecare IR Ltd | Health & social care | 2017 |
| Smileworldsalon Limited | Other services | 2025 |
| Smiling Miles Education Ltd | Administrative & support | 2024 |
| Smith and Agar Limited | Arts & recreation | 2009 |