| Datalec (UK) Ltd | Construction | 2011 |
| Datalyticz Ltd | Information & communication | 2017 |
| Dataserve Limited | Information & communication | 2023 |
| Dataverse Solutions Ltd | Information & communication | 2014 |
| Dave the Trimmer - Classic & Custom Vehicle Upholstery Ltd | Wholesale & retail | 2019 |
| Dave Tulett Remote Heads Limited | Information & communication | 2016 |
| Davenport's Construction Ltd | Construction | 2020 |
| David Armitage Consulting Limited | Professional & scientific | 2023 |
| David Bowen Commercial Limited | Real estate | 2010 |
| David Crowder Landscapes Limited | Administrative & support | 2014 |
| David Grainger Limited | Manufacturing | 2020 |
| David Long Marketing Limited | Professional & scientific | 2016 |
| David Meades Electrical Ltd | Construction | 2017 |
| David Oakley and Associates Limited | Professional & scientific | 2018 |
| David Pawson Publishing Limited | Wholesale & retail | 1960 |
| Davidson & Pearson Ltd | Wholesale & retail | 2004 |
| Davidson House Ltd | Households | 2021 |
| Davon Investments Ltd | Financial services | 2016 |
| Davon Limited | Extraterritorial | 2025 |
| Davos Close Management Company Limited | Households | 1982 |
| Davtee Investments Limited | Construction | 1972 |
| Daxom UK Ltd | Wholesale & retail | 2019 |
| Daylight Children's Care Services Limited | Health & social care | 2025 |
| DB Metals Ltd | Wholesale & retail | 2025 |
| DB Remote OPS Limited | Administrative & support | 2015 |
| Dbep Limited | Manufacturing | 2018 |
| DC Business Services Ltd | Real estate | 1997 |
| DC Carpentry & Facades Ltd | Construction | 2026 |
| DC Izelle Hair & Beauty Limited | Other services | 2024 |
| DC Squared Limited | Construction | 2003 |
| Dccis - UK Ltd | Other services | 2020 |
| Dchasetm Ltd | Construction | 2022 |
| DCN Mentoring Limited | Financial services | 2024 |
| DCN Selling Limited | Wholesale & retail | 2021 |
| DE Angelis Management Limited | Information & communication | 2012 |
| DE Angelis Publishing Limited | Information & communication | 2006 |
| DE Angelis Records Limited | Manufacturing | 2006 |
| Dealtrade Limited | Wholesale & retail | 1985 |
| Dean Clean Company Ltd | Administrative & support | 2013 |
| Debraye House Management Company Limited | Households | 2022 |
| Decomimaster Ltd | Wholesale & retail | 2026 |
| Decorative Glass and Mirrors Ltd | Manufacturing | 2025 |
| Decwell Limited | Construction | 2003 |
| Deej Technology Ltd | Administrative & support | 2025 |
| Deema PVT Limited | Administrative & support | 2016 |
| Deemac Networks Limited | Information & communication | 2008 |
| Deepcut Garage Limited | Wholesale & retail | 1962 |
| Deepfield Medical Limited | Health & social care | 2023 |
| Deepwater EU Ltd | Professional & scientific | 1999 |
| Deerfoot Holdings Limited | Financial services | 2018 |
| Deerfoot I. T. Resources Limited | Administrative & support | 2018 |
| Deerfoot Recruitment Solutions Limited | Information & communication | 1997 |
| Deesha AI Ltd | Information & communication | 2024 |
| Deestack Limited | Information & communication | 2024 |
| Deezee Properties Ltd | Real estate | 2022 |
| Defobuild Ltd | Construction | 2023 |
| Deli Class Limited | Wholesale & retail | 2016 |
| Delightfully British Limited | Wholesale & retail | 2015 |
| Delphic HSE Solutions Limited | Administrative & support | 2005 |
| Delta Controls Limited | Professional & scientific | 2019 |
| Delta International Consultancy Limited | Extraterritorial | 1991 |
| Delta Mobrey Limited | Manufacturing | 2005 |
| Deluxplays Limited | Information & communication | 2026 |
| Demir Build Limited | Construction | 2008 |
| Denbigh House Management Limited | Real estate | 1972 |
| Denis Rawlins Limited | Wholesale & retail | 1981 |
| Denistoun Investments | Construction | 1984 |
| Dennington Decorators Ltd | Administrative & support | 2004 |
| Dent Finesse PDR Ltd | Wholesale & retail | 2023 |
| Dental Professionals Today Recruitment Limited | Administrative & support | 2022 |
| Denzil Road (Guildford) Management Company Limited | Households | 2017 |
| Deol Estates Ltd | Real estate | 2015 |
| Depicus Limited | Information & communication | 2015 |
| Dermatura Limited | Health & social care | 2024 |
| Design by Create Ltd | Professional & scientific | 2025 |
| Design by Wilson Limited | Professional & scientific | 2010 |
| Desk Depot UK Ltd | Wholesale & retail | 2026 |
| Dessi Hospitality Ltd | Hospitality | 2025 |
| Destan Group Ltd | Administrative & support | 2018 |
| Detica Group Limited | Financial services | 1997 |
| Deuxpois Limited | Financial services | 2016 |
| Develop Leadership Ltd | Administrative & support | 2023 |
| Devine Inspired Care & Temporary Recruitment Agency Ltd | Administrative & support | 2022 |
| Devnest Limited | Information & communication | 2024 |
| Devonshire Carpentry Ltd | Construction | 2023 |
| Devonshire Marketing Consultants Limited | Administrative & support | 1994 |
| Dewhurst Holdings Limited | Extraterritorial | 2008 |
| Dewhurst Lettings Limited | Extraterritorial | 2008 |
| DEY Saha Services Ltd | Hospitality | 2021 |
| Deyoung Design & Build Limited | Construction | 2019 |
| Deyoung Developments Ltd | Construction | 2019 |
| Dfsmfdelt Ltd | Manufacturing | 2026 |
| DG Lighting Limited | Information & communication | 2014 |
| Dg&Ps Ltd | Public administration | 2024 |
| DH Voramar Ltd | Real estate | 2019 |
| Dhaulagiri Construction Ltd | Construction | 2025 |
| DHC Facilities Ltd | Construction | 2025 |
| Dhiyo Edha Limited | Information & communication | 2023 |
| Dhowen Legal Limited | Professional & scientific | 2024 |
| DI Carpenters & Maintenance Ltd | Construction | 2022 |