| DTE Business Advisers Group Limited | Financial services | 2012 |
| DTE Insurance Brokers Limited | Extraterritorial | 1976 |
| DTE Nominees Limited | Extraterritorial | 2001 |
| DTE Risk and Financial Management Limited | Financial services | 1985 |
| DTE Wealth Management Limited | Financial services | 2016 |
| Dtmc Properties Ltd | Real estate | 2025 |
| DTW Medico-Legal Services Limited | Health & social care | 2023 |
| Dualchas Management Ltd | Other services | 2016 |
| Dukangroup Ltd | Wholesale & retail | 2022 |
| Dukes Court & Wellington Road Management Company Limited | Households | 2006 |
| Dumers Cafe Ltd | Hospitality | 2024 |
| Duncan & Longstaff Investments Ltd | Real estate | 2019 |
| Dunder Mifflin Inc Limited | Hospitality | 2025 |
| Dungeon Inn (Tottington) Ltd | Hospitality | 2026 |
| Dunrave Plant Services Limited | Wholesale & retail | 2010 |
| Durhamld Limited | Professional & scientific | 2010 |
| Dusted Media Limited | Information & communication | 2014 |
| Dutch Fish & Chips Limited | Hospitality | 2020 |
| Dutch Style Ltd | Hospitality | 2025 |
| Dutton Doghouse Limited | Other services | 2002 |
| DV8 Technical Ltd | Information & communication | 2025 |
| DWC Scaffolding Ltd | Construction | 2025 |
| Dwellco Ltd | Real estate | 2020 |
| DWK Ltd | Health & social care | 2025 |
| Dydrm Ltd | Hospitality | 2020 |
| Dynamic Coaching Group Ltd | Education | 2026 |
| Dynamic Electrical Technologies Ltd | Construction | 2025 |
| Dynamics Gym Limited | Arts & recreation | 2013 |
| Dywidag Limited | Construction | 1999 |
| E & S Services (DAR) Limited | Other services | 2002 |
| E C R Technology Services Ltd | Information & communication | 2013 |
| E.H.S. (International) Limited | Wholesale & retail | 2012 |
| EA Hair Group Ltd | Other services | 2019 |
| EAD Auto Body Ltd | Wholesale & retail | 2025 |
| Eagle and Family Limited | Wholesale & retail | 2019 |
| Eagle Electric Services Ltd | Construction | 2016 |
| Eagle IT Ltd | Other services | 2021 |
| Eagles Estate Ltd | Real estate | 2017 |
| Eagles Nest (Butterstile Lane) Limited | Households | 1971 |
| EAL Hub Limited | Education | 2018 |
| EAP Properties Limited | Real estate | 2018 |
| EAR Spa Ltd | Health & social care | 2025 |
| Earlestown Decorating Centre Limited | Transport & logistics | 1975 |
| Early Break | Health & social care | 1997 |
| Early Learning Daycare Limited | Health & social care | 2016 |
| Easilife Limited | Administrative & support | 1996 |
| East Investment Ventures Ltd | Wholesale & retail | 2024 |
| East Lancashire Light Railway Company Limited | Wholesale & retail | 1986 |
| East Lancashire Railway Limited | Arts & recreation | 2019 |
| East Lancashire Railway Trust Limited | Transport & logistics | 1984 |
| East Star Trans Ltd | Transport & logistics | 2015 |
| East-West Service Ltd | Information & communication | 2015 |
| Eastwood Holdings Ltd | Real estate | 2022 |
| Easy Airport Transferz Ltd | Other services | 2022 |
| Easy Damp Ltd | Construction | 2022 |
| Easy Factors Limited | Professional & scientific | 2000 |
| Easy Home Express Ltd | Real estate | 2012 |
| Easybuild Solutions Ltd | Construction | 2018 |
| Easykeep Limited | Information & communication | 1990 |
| Eatonpeck Prop Co Ltd | Real estate | 2025 |
| EB Hairdressing Ltd | Other services | 2023 |
| EB Jewellery Ltd | Other services | 2024 |
| EC Developments Ltd | Construction | 2016 |
| EC Energy Limited | Professional & scientific | 2005 |
| Eccles Fold Management Company Limited | Households | 2005 |
| Ecclesholme Ltd | Health & social care | 2022 |
| ECG Fitness Limited | Wholesale & retail | 2020 |
| Echosoul Ltd | Professional & scientific | 2017 |
| Ecjs Property Ltd | Real estate | 2026 |
| Eclectric East Ltd | Construction | 2021 |
| Eclipse NDT Ltd | Professional & scientific | 2012 |
| Ecluminar Studios and Trading Co Ltd | Wholesale & retail | 2026 |
| Eco Car Charging Solutions Limited | Construction | 2021 |
| Eco FAB Supplies Ltd | Manufacturing | 2026 |
| Eco Greentech Energy Ltd | Construction | 2024 |
| Eco Providers Ltd | Construction | 2017 |
| Eco Surveyors 2020 Limited | Other services | 2020 |
| ECO3INSTALLATIONS Limited | Professional & scientific | 2019 |
| ECO3INSTALLS Ltd | Professional & scientific | 2019 |
| Ecobag (UK) Holdings Limited | Financial services | 2019 |
| Ecobag (UK) Ltd. | Wholesale & retail | 2014 |
| Ecobag 360 Group Limited | Administrative & support | 2020 |
| Ecofix Plumbing Solutions Ltd | Construction | 2023 |
| Ecogreen Glazing Ltd | Manufacturing | 2023 |
| Ecom Gate Ltd | Wholesale & retail | 2024 |
| Econurture Ltd | Construction | 2025 |
| Ecore Technology Ltd | Wholesale & retail | 2019 |
| Ecovision Homes Limited | Construction | 2025 |
| ECR Academy Ltd | Education | 2025 |
| Eczanum Ltd | Administrative & support | 2025 |
| ED Eaton Sound Ltd | Information & communication | 2026 |
| ED for ALL Ltd | Education | 2022 |
| Ed's Fire Save Ltd | Public administration | 2023 |
| Ed's Hair (Bramhall) Ltd | Other services | 2015 |
| EDC Healthcare Services Limited | Health & social care | 2026 |
| Eddiema Home Maintenance & Construction Limited | Construction | 2026 |
| Edemos Ltd | Information & communication | 2024 |
| Eden Animal Haven Limited | Agriculture & fishing | 2024 |
| Eden Coaching & Wellness Ltd | Other services | 2025 |
| Eden JC Ltd | Construction | 2024 |