| Surya Enterprises Limited | Administrative & support | 2014 |
| Susan L Smith Ltd | Health & social care | 2022 |
| Susan Ocha Limited | Wholesale & retail | 2023 |
| Susan Sparks Design Ltd | Information & communication | 2015 |
| Susati Ltd | Information & communication | 2026 |
| Suse Retail Ltd | Wholesale & retail | 2023 |
| Susettes Flowers Limited | Wholesale & retail | 2026 |
| Sushi Pops Ltd | Wholesale & retail | 2025 |
| Sussex Hospitality Management Ltd | Hospitality | 2020 |
| Sussex Specialist Cardiology Limited | Health & social care | 2020 |
| Sussex Wine Bars Ltd | Wholesale & retail | 2022 |
| Sustainable Living Holdings Limited | Other services | 2024 |
| Sutor Investments Limited | Real estate | 1978 |
| Suttra Holding Group Ltd | Hospitality | 2023 |
| SV Collective Ltd | Wholesale & retail | 2026 |
| Svaiy Art Industries Ltd | Information & communication | 2024 |
| Svaroda Music Group Ltd | Information & communication | 2025 |
| SVD Properties Limited | Real estate | 2019 |
| Svelte Living Investments Ltd | Real estate | 2018 |
| SVO Legal Consulting Ltd | Professional & scientific | 2016 |
| SW Morgan Ltd | Real estate | 2025 |
| SW Music Academy CIC | Education | 2025 |
| Swanbridge Limited | Information & communication | 2025 |
| Swann Close (Stowmarket) Management Company Limited | Households | 2005 |
| Swapspace Europe Ltd | Information & communication | 2025 |
| Swarm Solutions Limited | Information & communication | 2025 |
| Swash Consulting Limited | Professional & scientific | 2015 |
| SWB Consultants Ltd | Real estate | 2020 |
| SWC Grounds Ltd | Administrative & support | 2026 |
| Swdw Holdings Co. Ltd | Professional & scientific | 2019 |
| Sweet 'N' Soft Play Ltd | Administrative & support | 2025 |
| Sweet Cherry Gardens Ltd | Households | 2025 |
| Swift Doors Ltd | Construction | 2019 |
| Swift Freehold Management Ltd | Real estate | 2025 |
| Swift Shop Ltd | Wholesale & retail | 2021 |
| Swift UK Property Investments Ltd | Water & waste | 2023 |
| Swiftlead Ltd | Information & communication | 2025 |
| Swiftserve Group Ltd | Administrative & support | 2023 |
| Swingly Ltd | Information & communication | 2024 |
| Swissfx Corporate Limited | Information & communication | 2024 |
| Swoollies Ltd | Manufacturing | 2025 |
| Swordfish Aviation Ltd | Transport & logistics | 2009 |
| Swordfish Holidays Limited | Extraterritorial | 2015 |
| Sycamorph Ltd | Information & communication | 2023 |
| Syedra Ltd | Wholesale & retail | 2024 |
| Sygma Homes Ltd | Real estate | 2026 |
| Sylvianette Cleaning Services Ltd | Administrative & support | 2024 |
| Symbiosia Community Interest Company | Education | 2021 |
| Symonds Farm Power Limited | Energy | 2009 |
| Symonds Walk (Badwell ASH) Management Company Limited | Households | 2024 |
| Symtex Development Ltd | Information & communication | 2025 |
| Synapse Holdings Limited | Financial services | 2024 |
| Synaptic Chemistry Ltd | Professional & scientific | 2026 |
| Sync Digital Limited | Professional & scientific | 2022 |
| Sync Inc Ltd | Information & communication | 2025 |
| Synergen Trading & Contracting Ltd | Wholesale & retail | 2025 |
| Synergis Media Ltd | Professional & scientific | 2017 |
| Synergy Places Ltd | Real estate | 2023 |
| Synergystic Consulting Ltd | Health & social care | 2020 |
| Syntastix Limited | Information & communication | 2023 |
| Syntech Research UK Limited | Professional & scientific | 2002 |
| Synthetic Labs (Holding) Limited | Financial services | 2023 |
| Synthetic Labs Limited | Professional & scientific | 2019 |
| Synthience Limited | Information & communication | 2018 |
| Synvelora System Structuring Ltd | Information & communication | 2026 |
| Synysis Ltd | Professional & scientific | 2012 |
| Sypp Ltd | Administrative & support | 2023 |
| Sysara. Ltd. | Professional & scientific | 1996 |
| Syslanta Infrastructure Limited | Information & communication | 2026 |
| System Assurance Services Limited | Professional & scientific | 2023 |
| Systems Managers Limited | Hospitality | 1993 |
| Systems Security Consulting Limited | Information & communication | 2022 |
| Szavay Property Group Ltd | Real estate | 2025 |
| T & M Whitehead Productions Ltd | Information & communication | 2014 |
| T & S Haulage Ltd | Transport & logistics | 2026 |
| T and B Assets Ltd | Real estate | 2021 |
| T B Project Management Limited | Administrative & support | 2021 |
| T Blackshaw Limited | Construction | 2012 |
| T Engall Limited | Real estate | 2012 |
| T M Retail Ltd | Wholesale & retail | 2022 |
| T Newton Electrical Ltd | Construction | 2023 |
| T Odyssey Ltd | Information & communication | 2021 |
| T P Bookings Ltd | Other services | 2021 |
| T Wave Diagnostics Ltd | Health & social care | 2012 |
| T&C Construction & Groundworks Ltd | Construction | 2016 |
| T&J Support Ltd | Health & social care | 2023 |
| T&M Modern Houses Limited | Construction | 2019 |
| T&S Nesh Ltd | Health & social care | 2026 |
| T-Stop Films Ltd | Information & communication | 2023 |
| T.Cepulis Limited | Transport & logistics | 2026 |
| T.K.Roofing (Suffolk) Ltd | Construction | 2022 |
| T.K.Roofing Ltd | Construction | 2019 |
| T.Kuzinevicius Limited | Transport & logistics | 2025 |
| T.Lukosevicius Ltd | Transport & logistics | 2025 |
| T.Watson Electrical Ltd | Construction | 2025 |
| T20 Events Ltd | Administrative & support | 2021 |
| T3 Property Ltd | Real estate | 2022 |
| Table Group Consulting Ltd | Professional & scientific | 2018 |
| Taboo Cartridges Ltd | Wholesale & retail | 2025 |
| Tabulous Cosmetics Ltd | Wholesale & retail | 2024 |