| Spectator Guides Ltd | Information & communication | 2026 |
| Spectify Ltd | Wholesale & retail | 2019 |
| Spectrum 19 Limited | Information & communication | 2017 |
| Spectrum Recruitment Limited | Administrative & support | 1989 |
| Speedbird Concorde Limited | Real estate | 2018 |
| Speedcraft Services Limited | Construction | 2025 |
| Spence and Hauser Ltd | Wholesale & retail | 2015 |
| Spencerk Ltd | Professional & scientific | 2021 |
| Sperrys Ltd | Professional & scientific | 2024 |
| Speyside Holidays Ltd. | Hospitality | 2019 |
| Sphinx Property Investments Ltd | Real estate | 2025 |
| Spice of UK Limited | Hospitality | 2024 |
| Spice Tandoori Darwen Limited | Hospitality | 2016 |
| Spicecycle Limited | Wholesale & retail | 2025 |
| Spiceflakes Limited | Manufacturing | 2025 |
| Spicer Group Limited | Professional & scientific | 2023 |
| Spikes Prestige Paintworks Limited | Extraterritorial | 2016 |
| Spilt Soil Studio Ltd | Information & communication | 2026 |
| Spin Clean Limited | Other services | 2005 |
| Spinal Integrity Ltd | Health & social care | 2022 |
| Spinal Surgery Ltd | Health & social care | 2010 |
| Spinner Tech Ltd | Information & communication | 2026 |
| Spinney Studios LLP | | 2023 |
| Spirada Services Ltd | Transport & logistics | 2024 |
| Spirit LVL Ltd | Manufacturing | 2026 |
| Spirited Ventures Limited | Information & communication | 2020 |
| Spiritual and Haunted Events Limited | Administrative & support | 2025 |
| SPJ Power Ltd | Construction | 2025 |
| SPK Stats Ltd | Information & communication | 2023 |
| Splitsea Limited | Manufacturing | 2022 |
| Spoke & Partners Ltd | Professional & scientific | 2026 |
| Spoke and Motor Ltd | Wholesale & retail | 2023 |
| Spoken World Productions Ltd | Education | 2009 |
| Sporting Trust Limited | Education | 2021 |
| Sports Demands Limited | Wholesale & retail | 2021 |
| Sports Equipment Supplies Ltd | Manufacturing | 2019 |
| Sports Events and Installations Limited | Construction | 2023 |
| Sports Innovation Limited | Wholesale & retail | 2012 |
| Sports Tours Plus Ltd | Administrative & support | 2007 |
| Sportsstarz Football Agent Ltd | Arts & recreation | 2018 |
| Sportswrap Ltd | Manufacturing | 2025 |
| Spraga Ltd. | Information & communication | 2016 |
| Spring Meadow Flowers Limited | Wholesale & retail | 2024 |
| Spring Naturals Limited | Wholesale & retail | 2025 |
| Spring Pharmacy Limited | Wholesale & retail | 2006 |
| Springfield Court Bury ST. Edmunds Management Company Limited | Households | 1972 |
| Springfield Group Ltd | Other services | 2013 |
| Springfield Road Day Nursery Ltd | Health & social care | 2020 |
| Springs Healthcare & Education Ltd | Wholesale & retail | 2026 |
| Sprinkles of Joy Ltd | Manufacturing | 2026 |
| Sprint Aviation Ltd | Manufacturing | 2018 |
| Sprout Sales & Lettings Ltd | Real estate | 2025 |
| Spruce Green Properties Ltd | Real estate | 2024 |
| Spruce Lane Property Management Ltd | Real estate | 2025 |
| Spud & Slice Ltd | Hospitality | 2025 |
| Sqauds Ltd | Wholesale & retail | 2021 |
| SQI Consultancy Ltd | Professional & scientific | 2022 |
| Sqlfluff Ltd | Information & communication | 2023 |
| Square Base Consulting Ltd | Information & communication | 2019 |
| Squidgey Bean Ltd | Wholesale & retail | 2021 |
| Squire & Sons Scaffolding Ltd | Construction | 2026 |
| SR Consultancy (Tamworth) Limited | Professional & scientific | 2025 |
| SR Plumbing NW Ltd | Other services | 2017 |
| SR Properties (Suffolk) Ltd | Real estate | 2026 |
| SRA Crown Holdings Ltd | Information & communication | 2025 |
| SRC Innovations Ltd | Professional & scientific | 2023 |
| SRI Maya Ltd | Wholesale & retail | 2017 |
| SRI Narvi Ltd | Wholesale & retail | 2026 |
| SRI Rama Digital Solutions Ltd | Wholesale & retail | 2025 |
| Srosne 1 Limited | Administrative & support | 1987 |
| Srosne 3 Limited | Professional & scientific | 2024 |
| Ssbd Records Ltd | Information & communication | 2021 |
| SSC Digiverse Ltd | Information & communication | 2026 |
| Sserg Ltd | Wholesale & retail | 2023 |
| SSG Properties Investment Limited | Real estate | 2023 |
| Ssqa Limited | Administrative & support | 2008 |
| SSR Suspension Ltd | Administrative & support | 2015 |
| ST Chads Capital Ltd | Wholesale & retail | 2026 |
| ST Edmund Property Management Ltd | Real estate | 2024 |
| ST Edmunds Care Ltd | Health & social care | 2017 |
| ST Edmunds Property Ltd | Real estate | 2025 |
| ST Edmunds Trust | Health & social care | 1977 |
| ST Edmundsbury Cathedral Enterprises Limited | Wholesale & retail | 1973 |
| ST Edmundsbury Wealth Management Ltd | Financial services | 2018 |
| ST Fabians Limited | Real estate | 2020 |
| ST Mary's Grange Otley Limited | Households | 2019 |
| ST Michael's Close Management Company Limited | Households | 1985 |
| ST Petronella Limited | Professional & scientific | 2014 |
| ST. Nicholas Hospice (Suffolk) | Health & social care | 1983 |
| ST. Peter's Court B.S.E. Limited | Households | 1986 |
| St.Edmundsbury Masonic Hall Company Limited | Hospitality | 1889 |
| Stable Edge Inventories Limited | Real estate | 2026 |
| Stacey Industries Ltd | Wholesale & retail | 2015 |
| Stack Integral Ltd | Information & communication | 2026 |
| Stack Stays Ltd | Real estate | 2026 |
| Stacked Games Ltd | Information & communication | 2025 |
| Stackhouse Auto Works Limited | Wholesale & retail | 2026 |
| Staffinity Ltd | Administrative & support | 2025 |
| Stageprime Group Ltd | Arts & recreation | 2023 |
| Stak Body Co Ltd. | Wholesale & retail | 2026 |