| Serpranky Ltd | Information & communication | 2025 |
| Serv Technology (UK) Limited | Wholesale & retail | 2024 |
| Serva One Ltd | Information & communication | 2023 |
| Servco Care Ltd | Health & social care | 2021 |
| Service 2 Car Limited | Wholesale & retail | 2010 |
| Service Partitions Limited | Construction | 1970 |
| Servicebase Ltd | Construction | 2010 |
| Servicedapartmentforyou Ltd | Hospitality | 2024 |
| Servicepals.Com Limited | Information & communication | 2002 |
| Serving Shop Ltd | Wholesale & retail | 2025 |
| Setacorp Limited | Wholesale & retail | 2026 |
| Sethcodoorstore Limited | Wholesale & retail | 2017 |
| Sethcohomestores.Co.Uk Ltd | Wholesale & retail | 2014 |
| Seven Eyes Properties Ltd | Real estate | 2024 |
| Seven Five Property Limited | Hospitality | 2024 |
| Seven Mile Investments Limited | Financial services | 2025 |
| Sevilla Introducers Ltd | Professional & scientific | 2023 |
| Seyi & Svelte Living Investments LLP | | 2018 |
| Seymour Information Consultants Ltd | Information & communication | 2018 |
| Seymour Training Ltd | Education | 2023 |
| SF Century Develope E-Commerce Co., Ltd | Wholesale & retail | 2025 |
| SF Group Trading Ltd | Wholesale & retail | 2025 |
| Sfrd Ltd | Construction | 2025 |
| SFX Engineering and Fabrication Limited | Professional & scientific | 2026 |
| SG Birch Services Limited | Information & communication | 2022 |
| SG Catton Limited | Professional & scientific | 2014 |
| SG Home Partners Limited | Real estate | 2024 |
| SG Properties Ltd | Real estate | 2023 |
| SGD Enterprises Ltd | Wholesale & retail | 2020 |
| SGF Consulting Ltd | Professional & scientific | 2025 |
| Sgla Ltd | Administrative & support | 2025 |
| Sgmm Solutions Ltd | Construction | 2025 |
| SGR Consulting Ltd | Professional & scientific | 2026 |
| SGS Housing Group Ltd. | Construction | 2019 |
| SGS Surgical Ltd | Wholesale & retail | 2023 |
| SH Studio Clothing Limited | Wholesale & retail | 2026 |
| Shaashvati Consulting Limited | Information & communication | 2024 |
| Shachi Enterprise Limited | Wholesale & retail | 2011 |
| Shae Properties Ltd | Real estate | 2025 |
| Shake Haven Limited | Hospitality | 2024 |
| Shakokani Orthopaedics Ltd | Health & social care | 2020 |
| Shakokani Properties Ltd | Real estate | 2022 |
| Shalom Capital Investments Ltd | Financial services | 2014 |
| Shamayim Ltd | Other services | 2026 |
| Shami Clothing Limited | Wholesale & retail | 2017 |
| Shan Niche Limited | Professional & scientific | 2025 |
| Shans Property Services Limited | Real estate | 2026 |
| Shardspace Ltd | Extraterritorial | 2023 |
| Sharepay Ltd | Professional & scientific | 2025 |
| Sharester Ltd | Extraterritorial | 2019 |
| Sharf Global Ltd | Wholesale & retail | 2024 |
| Shark Plata Media Ltd | Arts & recreation | 2025 |
| Sharleen Nicholson Limited | Other services | 2023 |
| Sharman Property Group Limited | Real estate | 2025 |
| Sharp Frost Cooling and Heating Limited | Construction | 2021 |
| Sharp Rhialtors Ltd | Real estate | 2020 |
| Sharp Strategic Ltd | Administrative & support | 2024 |
| Sharpform Studio Ltd | Manufacturing | 2025 |
| Sharpshot Group Ltd | Information & communication | 2026 |
| Shartech Consulting Ltd | Information & communication | 2014 |
| Shat Bhai Spice Limited | Hospitality | 2025 |
| Shaun Cousens Limited | Information & communication | 2018 |
| Shaun Sellars Ltd | Health & social care | 2018 |
| SHC Consultancy Limited | Professional & scientific | 2017 |
| Shea Love Limited | Extraterritorial | 2013 |
| Shebbys Law Limited | Professional & scientific | 2024 |
| Sheepasleep Ltd | Health & social care | 2022 |
| Sheerness Property Limited | Real estate | 2002 |
| Sheida Javid Ltd | Health & social care | 2024 |
| Shelbourne Reynolds Engineering Limited | Manufacturing | 1972 |
| Sheltonsystems Ltd | Information & communication | 2026 |
| Shen Catering Ltd | Hospitality | 2016 |
| Shengyao Brilliance Trading Ltd | Wholesale & retail | 2026 |
| Shenzhen Xikoute Cosmetics Limited | Wholesale & retail | 2026 |
| Shepartners Ltd | Administrative & support | 2026 |
| Shephard Enterprises Limited | Real estate | 2018 |
| Shepherds Rest Holidays Ltd | Hospitality | 2003 |
| Sherod's Ventures Ltd | Professional & scientific | 2015 |
| Sheron Alves Limited | Information & communication | 2022 |
| Sherwood Specialist Services Limited | Professional & scientific | 1992 |
| Shetney Wilvon Ltd | Information & communication | 2012 |
| Shield Pro Limited | Wholesale & retail | 2025 |
| Shielding Lake Limited | Information & communication | 2018 |
| Shift Destiny Limited | Wholesale & retail | 2026 |
| Shimpling Park Farms Limited | Agriculture & fishing | 1955 |
| Shine Bury ST Edmunds CIC | Health & social care | 2025 |
| Shine Business Services Ltd | Administrative & support | 2021 |
| Shine Corp Housing Ltd | Real estate | 2025 |
| Shine Corp Property Ltd | Real estate | 2025 |
| Ship Happens and WE Deliver Limited | Wholesale & retail | 2016 |
| Shipmatic Limited | Information & communication | 2025 |
| Shipnext Ltd | Wholesale & retail | 2026 |
| Shira G Ltd | Professional & scientific | 2016 |
| Shire Technology Services Ltd | Information & communication | 2026 |
| Shirehall Apartments Management Co Limited | Households | 2026 |
| Shirleybear Studio Ltd | Wholesale & retail | 2025 |
| Shirocorp Consulting Limited | Professional & scientific | 2019 |
| SHK Marketing Ltd | Manufacturing | 2019 |
| SHL Group Holdings Limited | Administrative & support | 2017 |
| SHL Maintenance Limited | Construction | 2006 |