| Saxxon Steel Ltd | Construction | 2026 |
| SB CAD Design Limited | Administrative & support | 2018 |
| Scalpcliffe Energy Ltd | Professional & scientific | 2013 |
| Scarsdale Consultants Limited | Professional & scientific | 2021 |
| Scent Maison Ltd | Wholesale & retail | 2026 |
| Sceptre Innovations Ltd | Education | 2025 |
| School of Kicking Ltd | Arts & recreation | 2018 |
| Scientifics Limited | Professional & scientific | 1996 |
| SCL Strategies Limited | Wholesale & retail | 2025 |
| Scoffi Ltd | Hospitality | 2025 |
| Scomark Pipe-Fittings International Limited | Manufacturing | 2008 |
| Scorpio Driving School Limited | Education | 2009 |
| Scorpion Production Group Ltd | Arts & recreation | 2003 |
| Scotch and Sauce Ltd | Wholesale & retail | 2024 |
| Scott Property Services (Midlands) Ltd | Real estate | 2019 |
| Scott's Civil Engineering Limited | Construction | 2015 |
| Scrumptiddly Limited | Wholesale & retail | 2013 |
| SDG Associates Ltd | Construction | 2020 |
| SDS Midlands Limited | Professional & scientific | 2019 |
| SDT Kent Bridge Garage Ltd | Wholesale & retail | 2010 |
| Se-Lfboxes Limited | Wholesale & retail | 2023 |
| Sealwood Farm Ltd | Real estate | 2025 |
| Sean Lyttle Consultancy Ltd | Information & communication | 2025 |
| Search for the Next Limited | Professional & scientific | 2015 |
| Sebs Healthcare Solutions Limited | Administrative & support | 2025 |
| Second Lyfe Ltd | Wholesale & retail | 2025 |
| Second Monitor Media Ltd | Information & communication | 2021 |
| Sector 17 Limited | Arts & recreation | 2015 |
| Sectorem Limited | Professional & scientific | 2013 |
| Secure Certification Limited | Information & communication | 2019 |
| Secure Entry Solutions Ltd | Manufacturing | 2025 |
| Secure Guard Training Solutions Ltd | Extraterritorial | 2023 |
| SECUREX01 Ltd | Administrative & support | 2019 |
| SEH Enterprises Ltd | Professional & scientific | 2018 |
| Select Frames Limited | Manufacturing | 2013 |
| Select Music Limited | Administrative & support | 2015 |
| Sell Your Cell Limited | Wholesale & retail | 2026 |
| SEN Gold Ltd | Wholesale & retail | 2025 |
| Sensual Massage Limited | Other services | 2025 |
| Sentinel Medicare Ltd | Health & social care | 2025 |
| SEP Property Ltd | Real estate | 2022 |
| Serene Yachting Limited | Professional & scientific | 2013 |
| Serenity Cleaning Ltd | Other services | 2023 |
| Serenity Heart Accommodation Limited | Hospitality | 2024 |
| Serious Waste Management Limited | Water & waste | 1995 |
| Seven Hills Retail Ltd | Wholesale & retail | 2023 |
| Sevenseas MSE Ltd. | Manufacturing | 2016 |
| SEVENTY74 Limited | Information & communication | 2023 |
| Seyuber Ltd | Transport & logistics | 2025 |
| SG Property Trading Ltd | Real estate | 2016 |
| SG Thermal Ltd | Construction | 2017 |
| SGA Real Estate Ltd | Real estate | 2024 |
| SH Outfits Bargain Ltd | Wholesale & retail | 2024 |
| SH Recruitment Group Ltd | Administrative & support | 2026 |
| Shabbysheepuk Limited | Manufacturing | 2024 |
| Shabir Shah Foundation CIC | Health & social care | 2024 |
| Shahbaz Yousaf Bibi Ltd | Transport & logistics | 2024 |
| Sham SMA Ltd | Transport & logistics | 2023 |
| Shanayayaz Ltd | Wholesale & retail | 2025 |
| Shaun Wilkins Limited | Other services | 2016 |
| Shawgrave Ltd | Manufacturing | 2026 |
| Shaws E&I Ltd | Construction | 2025 |
| Sheepwalk Cottage Limited | Wholesale & retail | 2007 |
| Shephards Business Consultancy Ltd | Professional & scientific | 2011 |
| Sheppard Innovations Ltd | Professional & scientific | 2018 |
| Sheps Properties Ltd | Real estate | 2025 |
| Sherwood Flying Club Limited(The) | Other services | 1957 |
| Shilton Classics Limited | Wholesale & retail | 2020 |
| Shilton Transport Limited | Transport & logistics | 2015 |
| Shinwatec Limited | Manufacturing | 1996 |
| Shirab Holding Ltd | Financial services | 2023 |
| Shirab Property Ltd | Real estate | 2023 |
| Shires Business Services Limited | Professional & scientific | 1987 |
| Shobnall Construction Ltd | Construction | 2026 |
| Shobnall Engineering Co.Limited | Manufacturing | 1969 |
| Shop Emone Ltd | Manufacturing | 2020 |
| Shop Solutions Midlands Ltd | Wholesale & retail | 2023 |
| Shore Engineering Limited | Professional & scientific | 2002 |
| Shri SAI Services Ltd | Health & social care | 2023 |
| Shrinkpack Limited | Professional & scientific | 2009 |
| Siabura Kloset Ltd | Wholesale & retail | 2026 |
| Siam Investment Ltd | Real estate | 2018 |
| Siam Trading Ltd | Hospitality | 2019 |
| Sick Fade Limited | Other services | 2024 |
| Sidley Cars Limited | Transport & logistics | 2026 |
| Sidnem Hospitality Ltd | Hospitality | 2025 |
| Sidrah K Consulting Ltd | Professional & scientific | 2024 |
| Sign UP (Installation & Maintenance) Limited | Manufacturing | 2018 |
| Sikend Ltd | Wholesale & retail | 2025 |
| Silcorub Limited | Wholesale & retail | 2025 |
| Silmat Ltd | Transport & logistics | 2020 |
| Silverhill Properties Limited | Construction | 1977 |
| Silvernitrate Films Ltd | Information & communication | 2014 |
| Silverwood Holdings Ltd | Hospitality | 2023 |
| Simeonov Cleaning Ltd | Administrative & support | 2023 |
| Simlaco Ltd | Construction | 2025 |
| Simon Richardson Legal Services Limited | Professional & scientific | 2017 |
| Simple Solutions Hub Limited | Wholesale & retail | 2025 |
| Simpli F&B Ltd | Wholesale & retail | 2025 |
| Simpli FAB Ltd | Wholesale & retail | 2025 |