| Sapori Southport Limited | Hospitality | 2023 |
| Savemoneyhub Ltd | Financial services | 2020 |
| SB Mortgages (UK) Ltd | Other services | 2012 |
| Scale GRP Ltd | Professional & scientific | 2024 |
| Schofield Richards Limited | Real estate | 2007 |
| Sea Haitch Ltd | Professional & scientific | 2025 |
| Secret Spa and Beauty Limited | Other services | 2015 |
| Secrets Medical Ltd | Health & social care | 2017 |
| SEO Samurai Ltd | Administrative & support | 2022 |
| Sephton Logistics Ltd | Transport & logistics | 2020 |
| Servisbot Limited | Information & communication | 2017 |
| SG Injury Limited | Health & social care | 2025 |
| Simpson Components Ltd | Wholesale & retail | 2024 |
| SJR Garage Equipment Ltd | Wholesale & retail | 2011 |
| SJR Properties (NW) Ltd | Real estate | 2017 |
| SKR North West Limited | Construction | 2021 |
| Smith & Co Financial Services Ltd | Financial services | 2022 |
| Snape Holdings NW Ltd | Financial services | 2025 |
| Soil Engineering Geoservices Limited | Construction | 1992 |
| Soil Engineering Limited | Extraterritorial | 1988 |
| Soletanche Limited | Extraterritorial | 1988 |
| Solmac Energy Holdings Limited | Financial services | 2026 |
| Southport Podcast Studio Limited | Information & communication | 2026 |
| Southport Property Services Limited | Real estate | 2001 |
| Southport Skip Hire Ltd | Water & waste | 2017 |
| Specialist Paving and Civil Engineering Ltd | Construction | 2024 |
| Starfield Property Ltd | Real estate | 2023 |
| Stayard Limited | Financial services | 2022 |
| Steve Alexander Aesthetics and Training Ltd | Other services | 2019 |
| STS Accounts Limited | Professional & scientific | 2019 |
| SW Hospitality Limited | Professional & scientific | 2019 |
| T Harrison Plant Limited | Transport & logistics | 2017 |
| T Rooney Investments Limited | Real estate | 2026 |
| T.E Lumsden & Sons Limited | Wholesale & retail | 2016 |
| Tachograph Analysis Consultants Limited | Transport & logistics | 1987 |
| Tailored Fire Solutions Ltd | Professional & scientific | 2025 |
| Talanoa Limited | Administrative & support | 2012 |
| Tammer UK Limited | Administrative & support | 2002 |
| Tandem Contracts Limited | Construction | 2009 |
| TEE to Green Accountancy Limited | Professional & scientific | 2023 |
| Tetrahedron Limited | Professional & scientific | 2004 |
| TG Capital Property Finance Limited | Financial services | 2026 |
| TG Capital Property Holdings Limited | Financial services | 2026 |
| TG Capital Property Services Limited | Financial services | 2026 |
| TG Legal Ltd | Professional & scientific | 2015 |
| TH33 Consultancy Ltd | Professional & scientific | 2025 |
| THE Carpet Shop (NW) Ltd | Wholesale & retail | 2014 |
| THE Coffee Bar (Southport) Limited | Hospitality | 2012 |
| THE Document Management Group Limited | Administrative & support | 2004 |
| THE Edge of Ormskirk Ltd | Hospitality | 2013 |
| THE Harry & Grace Simpson Investment Company | Real estate | 2014 |
| THE Hastings Artisan Deli Limited | Hospitality | 2026 |
| THE Kitchen Equipment Company Limited | Wholesale & retail | 1993 |
| THE Liverpool Warehousing Company Ltd | Administrative & support | 2021 |
| THE Modern Style Store Limited | Other services | 2023 |
| THE Original Burscough Aquatics Store Limited | Wholesale & retail | 2015 |
| THE OWL Consortium Limited | Professional & scientific | 2018 |
| THE Parbold Bottle Limited | Manufacturing | 2018 |
| THE Partnership Group Limited | Professional & scientific | 2016 |
| THE Rufford Land Company Limited | Real estate | 1994 |
| THE Surprise Entertainment Company Ltd | Arts & recreation | 2024 |
| Theseus Investment Holdings Ltd | Financial services | 2023 |
| Tidy Graves Limited | Other services | 2021 |
| Tiny Treasures of Churchtown Ltd | Wholesale & retail | 2023 |
| TJW Contracting (NW) Limited | Manufacturing | 2013 |
| TM & RV Limited | Professional & scientific | 2011 |
| Tomandtom Limited | Professional & scientific | 2016 |
| Torbay Watersports Ltd | Arts & recreation | 2025 |
| Tour DE Franks Limited | Hospitality | 2023 |
| Tratini Limited | Information & communication | 2011 |
| Travelwithease Ltd | Administrative & support | 2025 |
| Trax Hydraulics (North West) Limited | Professional & scientific | 2004 |
| Turnkey Systems Limited | Professional & scientific | 2001 |
| UK Crematoria Limited | Extraterritorial | 2001 |
| UK Jetwash Screens Limited | Manufacturing | 2019 |
| UK Plant Limited | Administrative & support | 2011 |
| UK Woodworking Machinery Ltd | Professional & scientific | 2007 |
| Ultra Commercial Catering Limited | Other services | 2023 |
| Undiscovered Value Ltd | Information & communication | 2025 |
| Unity Strength & Conditioning Limited | Arts & recreation | 2019 |
| Upgradesystem Limited | Information & communication | 2001 |
| V Pack (Sales) Limited | Manufacturing | 1983 |
| V.A. Business Services Limited | Administrative & support | 2006 |
| Vendstop UK Limited | Wholesale & retail | 2010 |
| Venton Vision Limited | Health & social care | 2012 |
| Verde Maintenance Limited | Professional & scientific | 2025 |
| Verde Services Limited | Professional & scientific | 2023 |
| Vibro Group Limited | Construction | 1986 |
| Vibro Menard Limited | Extraterritorial | 1996 |
| Vision Landscapes Design & Construction Limited | Administrative & support | 2013 |
| Vitagenetix Ltd | Wholesale & retail | 2023 |
| Volt Fitness UK Limited | Arts & recreation | 2016 |
| W.I.P Southport Limited | Energy | 2017 |
| Walsh Construction (North West) Limited | Construction | 1999 |
| Walter Brown Printers Limited | Manufacturing | 2004 |
| Warren Farm Livery Limited | Arts & recreation | 2006 |
| Warren Farm Shows Limited | Arts & recreation | 2006 |
| Wedlow Developments Limited | Construction | 2005 |
| West Lancashire Crematorium Limited | Other services | 1998 |
| West Lancs Developments Limited | Construction | 2020 |