| RSK Building Services Limited | Construction | 2015 |
| Russ James Design Limited | Professional & scientific | 2001 |
| Ruthode Limited | Information & communication | 2022 |
| Ruthode Properties Limited | Real estate | 2024 |
| RVD Contractors Ltd | Construction | 2014 |
| S a Contracts (Midlands) Limited | Construction | 2022 |
| S Jones Plant Hire & Sales Limited | Wholesale & retail | 2011 |
| S L Packaging & Transport Limited | Manufacturing | 2019 |
| S&M Fire & Safety Solutions Ltd | Administrative & support | 2024 |
| S&S Plumbing & GAS Ltd | Construction | 2014 |
| S. Lester Packing Materials Limited | Manufacturing | 2008 |
| S. W. Plates Limited | Wholesale & retail | 2018 |
| Salesy Group Ltd | Professional & scientific | 2025 |
| SAM Elton Ltd | Construction | 2023 |
| Sanito's Touch Ltd | Water & waste | 2025 |
| Sankey's Market Ltd | Wholesale & retail | 2024 |
| Sankeys Barbers Ltd | Other services | 2023 |
| Sankeys Mini Market Ltd | Wholesale & retail | 2024 |
| Sankeys Store Ltd | Wholesale & retail | 2024 |
| Sankeys Vape Ltd | Wholesale & retail | 2025 |
| Saxon Chase Recruitment Limited | Administrative & support | 2019 |
| SC General Haulage Ltd | Transport & logistics | 2023 |
| Scaffold Connect Limited | Construction | 2014 |
| Scafform Connect Ltd | Construction | 2025 |
| Scenestream Limited | Information & communication | 2025 |
| Scomac Catering Group Ltd | Professional & scientific | 2024 |
| Scott Latham Ecological Biodiversity Ltd | Professional & scientific | 2024 |
| Secure Data Shredding Ltd | Administrative & support | 2025 |
| Securefit Solutions Ltd | Other services | 2024 |
| Security Labels International Limited | Extraterritorial | 2008 |
| Securofort Limited | Administrative & support | 2025 |
| SEE to IT Opticians Ltd | Wholesale & retail | 2021 |
| Selected Gourmet UK Ltd | Administrative & support | 2025 |
| Self Empower Ltd | Health & social care | 2023 |
| Sellerfuse Ltd | Information & communication | 2025 |
| Sensible Marketing Limited | Administrative & support | 2012 |
| Sentinel Fire & Security Systems Limited | Administrative & support | 2008 |
| Serenity Studio Boutique Ltd | Wholesale & retail | 2026 |
| Services Cleaning Ltd | Administrative & support | 2026 |
| Sgrant-Consultancy Ltd | Professional & scientific | 2018 |
| Shane Walsh Limited | Professional & scientific | 2014 |
| Share Properties Limited | Real estate | 2006 |
| Sharp Bookkeeping (Devon) Limited | Professional & scientific | 2026 |
| Sharp Bookkeeping (Yorkshire) Limited | Professional & scientific | 2026 |
| Sharp Bookkeeping Ltd | Construction | 2022 |
| Shel's PUB Company Ltd | Hospitality | 2025 |
| Shell Island Estates Limited | Real estate | 2006 |
| Shelley&Sons Security Fencing and Gates Ltd | Construction | 2022 |
| Sign Language Interpreting Services Ltd | Professional & scientific | 2021 |
| Silver and Gold by Birch Ltd | Manufacturing | 2024 |
| Silver Lining Property Investments Ltd | Real estate | 2025 |
| Simpson's Cosmetic Paint Repairs Limited | Administrative & support | 2010 |
| Sitescapes Limited | Professional & scientific | 2021 |
| SJC Consultancy Solutions Limited | Administrative & support | 2010 |
| Skala Contracts Limited | Administrative & support | 2013 |
| Skala Holdings Limited | Administrative & support | 2022 |
| Sky-Bot Limited | Administrative & support | 2025 |
| Skyline AV Ltd | Construction | 2022 |
| Slick Luck Media Limited | Manufacturing | 2024 |
| Smart Balustrades Limited | Manufacturing | 2016 |
| Smart CNC Ltd | Manufacturing | 2015 |
| Smart Repair (Staffs) Ltd | Wholesale & retail | 2026 |
| Smart Solutions (Automotive) Ltd | Wholesale & retail | 2023 |
| Smarts Plastering Limited | Construction | 2014 |
| SMJ Crown Limited | Financial services | 2012 |
| SMQ Commerce Ltd | Wholesale & retail | 2026 |
| Snackaway Limited | Manufacturing | 2006 |
| Sohaz Maritime Services Limited | Transport & logistics | 2020 |
| Solace Health Ltd | Administrative & support | 2026 |
| Solo Surveying Consultancy Ltd | Construction | 2004 |
| Solutions 4 Polymers Limited | Education | 2009 |
| South East Staffordshire Citizens Advice Bureau | Other services | 2009 |
| South Staffordshire Developments Limited | Real estate | 2024 |
| South Staffs Computers Ltd | Information & communication | 2016 |
| South Staffs Roofing Group Ltd | Construction | 2023 |
| Spec-Al Facades Limited | Other services | 1993 |
| Spice Lounge (Chase Town) Ltd | Hospitality | 2019 |
| Spirit of Rhyl Ltd | Hospitality | 2025 |
| SPM Group Midlands Limited | Financial services | 2022 |
| Spray Crane Ltd | Manufacturing | 2023 |
| Sprayman UK Limited | Manufacturing | 2014 |
| Square Circles Classroom Ltd | Professional & scientific | 2025 |
| Square Circles Hospitality Ltd | Professional & scientific | 2025 |
| Square Circles Living Ltd | Real estate | 2025 |
| Square Circles Renovation Ltd | Construction | 2025 |
| Square Circles Retail & Commercial Ltd | Construction | 2025 |
| Square Circles Workspaces Ltd | Professional & scientific | 2025 |
| Squiggles Childcare Limited | Health & social care | 2007 |
| Squire Automotive Services Limited | Wholesale & retail | 2006 |
| Squirrel Adhd Services Ltd | Health & social care | 2021 |
| SR Landscaping Services Ltd | Administrative & support | 2026 |
| Stafford Mobile Bodywork Limited | Wholesale & retail | 2018 |
| Staffordshire Industrial Doors Limited | Manufacturing | 2000 |
| Staffordshire Pallet Outlet Ltd | Wholesale & retail | 2024 |
| Staffordshire Signs & Graphic's Limited | Manufacturing | 1988 |
| Staffordshire Signs Limited | Manufacturing | 2012 |
| Staffordshire Wrapz Limited | Manufacturing | 2014 |
| Stag Lifting Services Limited | Manufacturing | 2025 |
| Star Parenting CIC | Education | 2024 |
| Steel Processing (Midlands) Limited | Manufacturing | 1992 |