| Rapid EYE Movies Limited | Information & communication | 1991 |
| Rashwood Energy Limited | Energy | 2022 |
| RAW Publications Limited | Extraterritorial | 2021 |
| Raw-Systems Limited | Information & communication | 2006 |
| Rawseo Limited | Extraterritorial | 2019 |
| Ready Careers Ltd | Administrative & support | 2020 |
| Red Circles Motorcycles Limited | Wholesale & retail | 2012 |
| Red Post Joinery Limited | Manufacturing | 2007 |
| Redono Ltd | Professional & scientific | 2017 |
| Reeds Coaching and Development Limited | Other services | 2014 |
| Refill Shop Community Interest Company | Wholesale & retail | 2018 |
| Regency Estates 1945 Limited | Construction | 2006 |
| Renshaw Associates Limited | Professional & scientific | 2002 |
| Residual Assets and Purposes (Trustees) Limited | Professional & scientific | 1990 |
| RESIN8 Limited | Professional & scientific | 2003 |
| Retro Football Shirt Store Ltd | Wholesale & retail | 2025 |
| Revnex Ltd | Wholesale & retail | 2025 |
| RHM Rentals Ltd | Real estate | 2024 |
| Richard Yendell Ltd | Information & communication | 2014 |
| Ride IT Cycles Ltd | Wholesale & retail | 2018 |
| Ripl Ltd | Professional & scientific | 2021 |
| Ripl Rotary Ltd | Professional & scientific | 2023 |
| Robert Wynter & Partners (Holdings) Limited | Professional & scientific | 2018 |
| Robin's Trading Company Ltd | Professional & scientific | 2009 |
| Robinson ILA Limited | Administrative & support | 2021 |
| ROK Saunas Ltd | Manufacturing | 2025 |
| Roost Holidays Ltd | Hospitality | 2019 |
| Rooted Healing Ltd | Arts & recreation | 2023 |
| Rooted Ocean Ltd | Manufacturing | 2021 |
| Rory Hodges Coaching Ltd | Health & social care | 2024 |
| Rosecare Farm Cottages Management Company Limited | Real estate | 2004 |
| Roselight Echo Limited | Information & communication | 2025 |
| Rosie's Kitchen Limited | Hospitality | 2008 |
| Roxburgh Family Limited | Hospitality | 2006 |
| Royal Flush Genetics Limited | Agriculture & fishing | 2024 |
| Rudi and Bear Limited | Manufacturing | 2019 |
| Rvvl Ltd | Professional & scientific | 2017 |
| RW Structural Ltd | Professional & scientific | 2024 |
| Ryan Vincent Homes Ltd | Construction | 2026 |
| SA Holdings Bude Ltd | Professional & scientific | 2023 |
| Safe Serve Flags Ltd | Professional & scientific | 2026 |
| SAM Breyley Fencing Limited | Construction | 2005 |
| SAM Edwards Garage LLP | | 2020 |
| Samuel Fairbairn Limited | Professional & scientific | 2024 |
| Sancheff Limited | Financial services | 2024 |
| Sanderson Accountants Ltd | Professional & scientific | 2009 |
| Sandilands Investments (Birmingham) Limited | Real estate | 1963 |
| Sanitycheck.Io Limited | Information & communication | 2017 |
| Saxton Contractors Ltd | Construction | 2023 |
| Scott K9 Cages Ltd | Manufacturing | 2022 |
| Sea Air Life Coaching Ltd | Administrative & support | 2025 |
| Sea Jade Guest House Limited | Hospitality | 2006 |
| Sectek Ltd | Information & communication | 2026 |
| Self Lifestyle Limited | Other services | 2020 |
| SF Equine Vets Ltd | Professional & scientific | 2019 |
| SH Carpentry and Joinery Ltd | Manufacturing | 2024 |
| Share Abundance | Other services | 2024 |
| Sharp Motorsport Ltd | Wholesale & retail | 2018 |
| Shell Belle Couture Ltd | Manufacturing | 2012 |
| Shellocean Limited | Wholesale & retail | 2016 |
| Shnrwe MBA Ltd | Wholesale & retail | 2025 |
| Sibo's Lifes a Beach Ltd. | Hospitality | 2003 |
| Silvatel Consulting Limited | Professional & scientific | 2008 |
| Simon Allen Plumbing & Heating Ltd | Construction | 2022 |
| Simple Water Solutions Limited | Manufacturing | 1997 |
| Sinden Solutions Limited | Information & communication | 2013 |
| Sips Ground Screws Limited | Wholesale & retail | 2021 |
| Sirimaya Ltd | Other services | 2017 |
| SIS Global Seating Limited | Manufacturing | 2016 |
| SIX Liqueurs Limited | Wholesale & retail | 2020 |
| SJL Group (SW) Ltd | Administrative & support | 2025 |
| Skandesign Limited | Professional & scientific | 2005 |
| SLR Competitions Ltd | Wholesale & retail | 2026 |
| Smiley Ltd | Financial services | 2025 |
| Smith & Co Enterprise Ltd | Administrative & support | 2018 |
| Smith & Co Jewellers Ltd | Wholesale & retail | 2020 |
| Smith RE Limited | Real estate | 2020 |
| Softbase Limited | Information & communication | 1989 |
| Solstar Power Limited | Energy | 2024 |
| Solstar PPC1 Limited | Energy | 2024 |
| Solstar PPC2 Limited | Energy | 2024 |
| Solstar PPC3 Limited | Energy | 2024 |
| Solstar PPC4 Limited | Energy | 2024 |
| Sonop Limited | Agriculture & fishing | 1956 |
| Sorwest Ltd | Manufacturing | 2018 |
| South West England Sustainable Enterprises (Trelay) Limited | Agriculture & fishing | 2007 |
| South West Powersports Limited | Wholesale & retail | 2013 |
| Southwest Retrofit & Epcs Ltd | Professional & scientific | 2023 |
| Sovereignty Ltd | Professional & scientific | 2026 |
| Specialists in Seating Limited | Manufacturing | 2020 |
| Spencer Montague Limited | Wholesale & retail | 2026 |
| Spencer Thorn Ltd | Wholesale & retail | 2012 |
| Spinning Mill 415 Ltd | Hospitality | 2022 |
| Spinriver Design Ltd | Real estate | 2009 |
| Squire Holidays Ltd | Hospitality | 2019 |
| Squirrel Nest Properties Limited | Real estate | 2016 |
| ST Petroleum Limited | Wholesale & retail | 2025 |
| Start Safety Limited | Information & communication | 2019 |
| Start Speed Bumps Direct Limited | Professional & scientific | 2008 |
| Start Traffic Management Limited | Professional & scientific | 2015 |