| Selkirk Holdings Limited | Financial services | 2022 |
| SES Healthcare UK Ltd | Wholesale & retail | 2022 |
| Set-Co Solutions Limited | Construction | 2024 |
| SG Studio Ltd | Information & communication | 2026 |
| Shannon Design and Management Limited | Professional & scientific | 2014 |
| Sharp Performance Limited | Arts & recreation | 2018 |
| Shaun Olbison Limited | Administrative & support | 2007 |
| Shaw Plantation Limited | Hospitality | 2017 |
| Shetland Pony and Friends Animal Therapy Ltd | Other services | 2024 |
| Shiyue Hull Ltd | Hospitality | 2025 |
| Shoebox Solutions Ltd | Professional & scientific | 2025 |
| Shore Club Financing Limited | Professional & scientific | 2023 |
| Sight Care UK Ltd | Health & social care | 2002 |
| Sight Properties Limited | Real estate | 2023 |
| Sight System Ltd | Health & social care | 2016 |
| Silver George Ltd | Construction | 2018 |
| Simple Accommodation Ltd | Hospitality | 2025 |
| Simply K9 Ltd | Other services | 2014 |
| Site and Technical Services Limited | Professional & scientific | 1987 |
| Sixty Two Trading Limited | Wholesale & retail | 2020 |
| Sixtyone QG Limited | Real estate | 2022 |
| Sixtythree TG Limited | Real estate | 2024 |
| SJ Holdings (East Yorkshire) Limited | Real estate | 2026 |
| SJ Transport Solutions Ltd | Transport & logistics | 2025 |
| SKA and Soul Limited | Wholesale & retail | 1997 |
| Skelwith Bridge Limited | Hospitality | 1980 |
| SL2 Prop Co Limited | Construction | 2018 |
| SLS Consulting Ltd | Financial services | 2012 |
| Smart Investco Ltd | Financial services | 2025 |
| Smart Training Solutions (UK) Limited | Professional & scientific | 2007 |
| Smudgeycards Ltd | Wholesale & retail | 2026 |
| Snap IT Photobooth Co Limited | Professional & scientific | 2024 |
| Soap&Co Ltd | Administrative & support | 2020 |
| Solar Consult Limited | Construction | 2024 |
| Solis Education CIC | Education | 2025 |
| Soter Properties Limited | Real estate | 2024 |
| Soulspace Pilates Ltd | Arts & recreation | 2025 |
| South Cave Tractors Limited | Manufacturing | 2006 |
| Sparkling Sunflower Limited | Administrative & support | 2014 |
| Sparrow 2010 Limited | Wholesale & retail | 2000 |
| Sparrow Recovery Limited | Wholesale & retail | 2011 |
| Specialist Financial Solutions Limited | Professional & scientific | 2019 |
| Speedi-Kleen (DRY Cleaners of Hull) Limited | Real estate | 1977 |
| Spoon Lettings Ltd | Real estate | 2017 |
| Spotted Zebra Consulting Ltd | Professional & scientific | 2022 |
| SPS Finance Ltd | Professional & scientific | 2018 |
| SPT Hotel & Catering Ltd. | Hospitality | 2020 |
| SQB Limited | Professional & scientific | 2022 |
| Squarepeg Education Ltd | Education | 2025 |
| Squash Travel Limited | Administrative & support | 2016 |
| Srees MED Limited | Health & social care | 2021 |
| SSC Global Associates Limited | Professional & scientific | 2021 |
| Stadium (Catcliffe) Limited | Extraterritorial | 2004 |
| Stadium (Vicar Lane) Limited | Construction | 1999 |
| Stadium Parkgate (Holdings) Limited | Professional & scientific | 2004 |
| Stadium Welton Limited | Construction | 1979 |
| Standish Property Holdings Ltd | Real estate | 2025 |
| Star Takeaway (East York) Limited | Hospitality | 2022 |
| Station House Hessle (2013) Ltd | Real estate | 2013 |
| Station Road (Brough) Residence Ltd | Real estate | 2024 |
| Station Supper Bar Ltd | Hospitality | 2022 |
| Staunch (Europe) Ltd | Professional & scientific | 2013 |
| Staunch (Green Shadows) Limited | Construction | 2011 |
| Staunch Limited | Construction | 2010 |
| Stem Architects Limited | Professional & scientific | 2008 |
| Stem Group Holdings (Lincoln) Limited | Professional & scientific | 2014 |
| Stem Management Group Limited | Financial services | 2023 |
| Stem Properties Limited | Extraterritorial | 2012 |
| Stephanie's Facial Aesthetics Limited | Other services | 2019 |
| Steve MAY Consulting Limited | Administrative & support | 2011 |
| Stnwinvest Ltd | Wholesale & retail | 2018 |
| Stockbridge Management Consultants Limited | Professional & scientific | 2004 |
| Stonegate Holdings Limited | Wholesale & retail | 2025 |
| Storm Customs Ltd | Administrative & support | 2017 |
| Storm Valeting Services Limited | Other services | 2002 |
| Strategy Room Consultancy Ltd | Information & communication | 2026 |
| Studentpad Limited | Information & communication | 2000 |
| Studentpad.Co.Uk Limited | Extraterritorial | 2000 |
| Sugar 'N' Spice Cakes Limited | Manufacturing | 2010 |
| Sutton Developments Ltd | Construction | 1986 |
| Sutton Holdings Limited | Professional & scientific | 1985 |
| Sutton Syndication Limited | Administrative & support | 2015 |
| Swift Holdings (UK) Limited | Real estate | 2003 |
| Swift Property (A1079) Limited | Real estate | 2013 |
| Swim Pods Ltd. | Education | 2014 |
| SWL Developments Limited | Construction | 2011 |
| SWL Finance Limited | Professional & scientific | 2017 |
| Sykes Consulting Ltd | Professional & scientific | 2023 |
| Sylvia LEA Ltd | Wholesale & retail | 2021 |
| Synergy Facilities Ltd | Administrative & support | 2018 |
| T-Tecs Marine Ltd | Professional & scientific | 2023 |
| T.A. Hebden & Co. (Leisure) Limited | Arts & recreation | 2004 |
| TA Virtual Solutions Limited | Administrative & support | 2025 |
| Tajj 2 Limited | Administrative & support | 2020 |
| Tajj Flowers Limited | Administrative & support | 2020 |
| Tajj Limited | Administrative & support | 1986 |
| Tax Investigations Limited | Financial services | 2000 |
| Tcgx Ltd | Wholesale & retail | 2024 |
| Tea-N-Bisque IT Ltd | Hospitality | 2017 |
| Techmedix Ltd | Information & communication | 2019 |