| S Balderson Ltd | Professional & scientific | 2024 |
| S C Rugg Holdings Limited | Financial services | 2021 |
| S C Rugg Limited | Construction | 2014 |
| S Durose Carpentry Ltd | Construction | 2016 |
| S Gowland Properties Limited | Real estate | 2019 |
| S J Clark Transport Ltd | Transport & logistics | 2021 |
| S J Rayner (Cars) Ltd | Wholesale & retail | 2016 |
| S Kaur Ltd | Health & social care | 2023 |
| S R Electrical Services Limited | Construction | 2003 |
| S R R Properties Ltd | Real estate | 2018 |
| S R R Services Ltd | Construction | 2008 |
| S&E Booth Holdings Limited | Administrative & support | 2018 |
| S&L Urban Developments Ltd | Real estate | 2025 |
| S&M Property Lettings Limited | Real estate | 2018 |
| S. K. S. Integrated Services Ltd | Construction | 2017 |
| S. Shots Ltd | Arts & recreation | 2025 |
| S.H. Engineering Wildmoor Limited | Professional & scientific | 2026 |
| S.K.S. Construction Limited | Construction | 1997 |
| S.Smith & Lyons(Developers)Limited | Construction | 1967 |
| S4F Ltd | Arts & recreation | 2011 |
| Saaq Ltd | Wholesale & retail | 2026 |
| Sacred Bridge Limited | Information & communication | 2025 |
| Sadaf Property Developers Ltd | Real estate | 2025 |
| Safe Pierce Limited | Wholesale & retail | 2016 |
| Safe Sites 360 Ltd | Information & communication | 2026 |
| Safesequence Ltd | Information & communication | 2026 |
| Safety Assured Scaffolding Ltd | Construction | 2019 |
| Safety Expertise Limited | Professional & scientific | 2024 |
| Safety Technology International (Europe) Limited | Extraterritorial | 2016 |
| Safety Technology International Limited | Manufacturing | 2006 |
| Saifullah Traders Ltd | Wholesale & retail | 2025 |
| Saint Marylebone Limited | Construction | 2016 |
| Saiyan Sports Enterprises Ltd | Arts & recreation | 2024 |
| Saka Consulting Limited | Professional & scientific | 2021 |
| Saka Investment Properties (Selly Oak) Limited | Real estate | 2021 |
| Salar Consultancy Limited | Professional & scientific | 2023 |
| SALES4GROWTH Limited | Professional & scientific | 2015 |
| Salt Productions Ltd | Information & communication | 2023 |
| Saltertongrove Ltd | Professional & scientific | 2013 |
| Salvador Solutions Limited | Information & communication | 2011 |
| SAM & Mandy Real Estate Limited | Real estate | 2023 |
| SAM Bain Limited | Arts & recreation | 2006 |
| SAM Scott Bills Ltd | Information & communication | 2025 |
| Sandude Limited | Financial services | 2021 |
| Sandy and Ginny Limited | Real estate | 2014 |
| Sangar Consulting Limited | Education | 2019 |
| Saniel Properties Ltd | Real estate | 2021 |
| Sanitas Hub Limited | Education | 2015 |
| Santis Group Holdings Ltd | Other services | 2019 |
| Sapsec Solutions Ltd | Information & communication | 2009 |
| SAQ Solutions Limited | Wholesale & retail | 2026 |
| Sara Davison Global Enterprises Limited | Health & social care | 2013 |
| Sarah & ZAK Solutions Ltd | Public administration | 2024 |
| Sarah Harvey Travel & Events Limited | Administrative & support | 2025 |
| Saralis Solutions Ltd | Manufacturing | 2025 |
| Sargent-Disc Limited | Professional & scientific | 1986 |
| Sass Hair & Beauty Ltd | Other services | 2019 |
| Satr Active Limited | Manufacturing | 2026 |
| Saunz Property Group Ltd | Real estate | 2026 |
| Sbak a F Solutions Ltd | Wholesale & retail | 2025 |
| Scallywags Barbers Ltd | Other services | 2022 |
| Scarlettom Limited | Wholesale & retail | 2024 |
| SCB Micro Limited | Information & communication | 2019 |
| Scenic Root Limited | Arts & recreation | 2014 |
| School Days Direct Limited | Wholesale & retail | 2008 |
| School House Private Day Nursery Limited | Education | 2003 |
| Schubert & Salzer (UK) Limited | Manufacturing | 1993 |
| Screampark Entertainments Limited | Arts & recreation | 2012 |
| Screed Solutions West Midlands Ltd | Construction | 2024 |
| Screenpro Limited | Manufacturing | 2004 |
| Scriptureart Ltd | Arts & recreation | 2024 |
| Scrivo Holdings Ltd | Financial services | 2026 |
| Scruffy Doll Productions Limited | Information & communication | 2025 |
| Scwo Ltd | Real estate | 2018 |
| SD Production Services Limited | Professional & scientific | 2004 |
| Sdms Security Products UK Limited | Administrative & support | 2007 |
| SE3D Printing Ltd | Manufacturing | 2022 |
| Seada AV Ltd | Wholesale & retail | 2018 |
| Seada Conference Limited | Manufacturing | 2018 |
| Seada Group Ltd | Manufacturing | 2022 |
| Seada Technology Ltd | Manufacturing | 2013 |
| Sean's Consulting Ltd | Professional & scientific | 2025 |
| Searle Solutions Ltd | Construction | 2020 |
| Seaturtle Software Ltd | Information & communication | 2011 |
| Second City Customs Ltd | Manufacturing | 2008 |
| Second City Resin Limited | Construction | 2024 |
| Second City Screed Limited | Construction | 2022 |
| Second Rodeo Films Ltd | Information & communication | 2024 |
| Second Tidbury (Yvonne Park) Management Company Limited | Administrative & support | 1982 |
| Second Tier Supply Ltd | Administrative & support | 2017 |
| Secrets of the Horse UK Limited | Agriculture & fishing | 2009 |
| Secure Gates Bromsgrove Ltd | Manufacturing | 2024 |
| Security Care Limited | Administrative & support | 2002 |
| Security Group Distribution Ltd. | Administrative & support | 1997 |
| Securo Solutions Ltd | Administrative & support | 2025 |
| Seemore Limited | Arts & recreation | 2010 |
| Seeright Consultancy Ltd | Administrative & support | 2024 |
| Segbourne Financial Management Limited | Financial services | 2000 |
| SEI Holdings Ltd | Real estate | 2019 |
| Select Mortgages UK Limited | Real estate | 2011 |