| Reds Hairdressing Salon Limited | Other services | 2012 |
| Reds Promotion & Marketing Ltd | Other services | 2011 |
| Redwood Developments (Wirral) Limited | Construction | 2003 |
| Referral Marketing Limited | Education | 2017 |
| Regal Fittings Ltd | Manufacturing | 2018 |
| Regenerative Advisory Limited | Administrative & support | 2023 |
| Remote Risk International Limited | Administrative & support | 2016 |
| Resolute Logistics Recruitment Solutions Ltd | Administrative & support | 2023 |
| Retina EYE Care Limited | Health & social care | 2020 |
| Rewinds and J. Windsor & Sons (Engineers) Limited | Manufacturing | 1958 |
| Rezk RAD Limited | Health & social care | 2022 |
| RH Radpath Limited | Health & social care | 2020 |
| Rhdd Engineering Limited | Professional & scientific | 2014 |
| RHI Solutions Limited | Administrative & support | 2026 |
| Ricco Bathrooms Ltd | Construction | 2023 |
| Rjab Marine Services Ltd | Transport & logistics | 2012 |
| Rjjl Developments Limited | Real estate | 2017 |
| RJW Engineering (Manchester) Limited | Manufacturing | 1975 |
| RKK Consultancy Limited | Professional & scientific | 2012 |
| Rllb Consultancy Ltd | Professional & scientific | 2024 |
| RM Services(Nw) Ltd | Agriculture & fishing | 2024 |
| RMB IT Consultancy Limited | Information & communication | 2011 |
| Rmets Services Limited | Professional & scientific | 2007 |
| Road to Rental Ltd | Real estate | 2011 |
| Rockhill Business Change Limited | Professional & scientific | 2015 |
| Rodrigues Holdings Limited | Real estate | 2016 |
| Rojomi Limited | Information & communication | 2021 |
| Roland Residential Limited | Real estate | 2013 |
| Rollwright (North West) Limited | Manufacturing | 2010 |
| Rosevere Engineering Limited | Professional & scientific | 2007 |
| RTS Engineering Limited | Professional & scientific | 2007 |
| RW Engineering Limited | Administrative & support | 2007 |
| Ryder Developments Limited | Real estate | 2018 |
| S & C Muff Limited | Wholesale & retail | 1996 |
| S & L Management Limited | Professional & scientific | 2020 |
| S Buckley Designs Limited | Administrative & support | 2011 |
| S J ORR Tyres Limited | Wholesale & retail | 2016 |
| S M Service Centre Limited | Manufacturing | 2022 |
| SAF Ventures Limited | Hospitality | 2025 |
| Salisbury Group Limited | Real estate | 2019 |
| Salisbury House Care Limited | Health & social care | 2020 |
| Salisbury Leisure Enterprises Limited | Hospitality | 2021 |
| Salisbury Management Services Limited | Health & social care | 1998 |
| Salisbury Maritime Consultants Ltd | Transport & logistics | 2015 |
| Salisbury Specialist Housing Limited | Real estate | 2020 |
| Salons Direct Limited | Wholesale & retail | 1995 |
| Salus Biosolution Limited | Professional & scientific | 2019 |
| Salus Services (N.W.) Ltd | Administrative & support | 2011 |
| Sandman Properties Ltd | Real estate | 2017 |
| Sandown Projects Ltd | Administrative & support | 2013 |
| Sandy Lane (Chester) Limited | Real estate | 2003 |
| Santovino Limited | Hospitality | 2025 |
| Sarah Elise Engineering Ltd | Professional & scientific | 2025 |
| Sarah's Embroidery Limited | Wholesale & retail | 2018 |
| Savona Property Investors Ltd | Real estate | 2024 |
| Scopecode (Greedy) Limited | Real estate | 1986 |
| Scopecode Group Limited | Professional & scientific | 1999 |
| Scopecode Limited | Real estate | 1981 |
| Seasoned Pioneers Limited | Manufacturing | 2000 |
| Seed Electrical Services Limited | Construction | 2014 |
| Sefton Automatics Limited | Administrative & support | 1968 |
| Selby Associates Limited | Administrative & support | 2010 |
| Selectaflex Consulting Ltd | Administrative & support | 2013 |
| Sencon Consulting Ltd | Professional & scientific | 2024 |
| Sentinel Supported Living Limited | Administrative & support | 2011 |
| SEO 530 Limited | Information & communication | 2014 |
| Serenity Beds and Aesthetics Ltd | Other services | 2024 |
| SG Civil Engineering Ltd | Construction | 2015 |
| SH Consultancy Solutions Limited | Professional & scientific | 2015 |
| SH Teleradiology Ltd | Health & social care | 2024 |
| Shane Williams Consultancy Ltd | Information & communication | 2024 |
| Shoreside Orthodontics Limited | Health & social care | 2023 |
| Showering Solutions Limited | Construction | 2002 |
| Silikas Scientific Ltd | Professional & scientific | 2020 |
| Silver & Rose Audiologists Ltd | Health & social care | 2019 |
| Simon Black Holdings Limited | Administrative & support | 2019 |
| Single Central Record Ltd | Information & communication | 2017 |
| Sitesolutionssatuk Ltd | Professional & scientific | 2015 |
| SIX TEN Highways and Traffic Ltd | Administrative & support | 2011 |
| SJ Veterinary Services Limited | Professional & scientific | 2019 |
| SJN Design Limited | Professional & scientific | 2007 |
| SJS Electrical & Plumbing Contractors Ltd | Construction | 2026 |
| SJS Electrical Contractors Limited | Construction | 2015 |
| SJS Plumbing Contractors Ltd | Construction | 2019 |
| Sketch West Limited | Real estate | 2005 |
| Slips Away Ltd | Wholesale & retail | 2019 |
| Smart Repair Co Limited | Wholesale & retail | 2003 |
| Smartchoice Properties Group Limited | Professional & scientific | 2013 |
| SMG International Ltd | Transport & logistics | 2020 |
| Smith DEV Ltd | Information & communication | 2015 |
| Smylie Limited | Wholesale & retail | 2003 |
| Solusyst Ltd | Information & communication | 2010 |
| Sophia Trading Limited | Wholesale & retail | 2026 |
| Spaceline Design Ltd | Wholesale & retail | 2020 |
| Special Engineering Services Ltd | Professional & scientific | 2019 |
| SPH Design Limited | Professional & scientific | 2008 |
| Spital Road Bromborough Management Company Limited | Households | 2023 |
| Splashed OUT Ltd | Arts & recreation | 2023 |
| SPR House Management Ltd | Real estate | 2016 |
| SPR Structural Engineering Limited | Professional & scientific | 2008 |