| Colour Glass Glazing Ltd | Construction | 2017 |
| Combat Sports Agency Limited | Health & social care | 2020 |
| Combatgas F-46 Engineering Ltd | Construction | 2005 |
| Combined FM Ltd | Administrative & support | 2024 |
| Compere Air Systems Limited | Administrative & support | 2003 |
| Complete Timber Frame Ltd | Construction | 2017 |
| CONCATEN8 Data Services Ltd | Information & communication | 2025 |
| Concept Maintenance (UK) Limited | Administrative & support | 2011 |
| Concept Projects Group Limited | Professional & scientific | 2018 |
| Confidence Builders Limited | Construction | 2014 |
| Connected Estates Limited | Real estate | 2022 |
| Connexus Engineering Limited | Administrative & support | 2015 |
| Conquest Games Limited | Administrative & support | 2008 |
| Construction Specialists NW Limited | Construction | 2022 |
| Container Care Solutions Limited | Manufacturing | 2007 |
| Contour Coaching & Advisory Ltd | Professional & scientific | 2026 |
| Contracts and Procurement Services Limited | Administrative & support | 2007 |
| Convent Gardens Management Company Limited | Households | 2002 |
| Core Additive Technologies Limited | Wholesale & retail | 2016 |
| Corp Networking Ltd | Information & communication | 2003 |
| Corporate & Personal Investment Planning Limited | Financial services | 1992 |
| Coss Solutions Limited | Manufacturing | 2018 |
| Cozy Day Nurseries Ltd | Education | 2015 |
| CPS Marine Services Limited | Transport & logistics | 2013 |
| CR Advanced Civil Engineering Ltd | Construction | 2018 |
| Cranham Limited | Administrative & support | 2007 |
| Crathorne Technical Services Limited | Administrative & support | 2008 |
| Creative Business Solutions (U.K.) Limited | Professional & scientific | 2001 |
| Creativo Limited | Professional & scientific | 2002 |
| Credit Management Group (UK) Limited | Administrative & support | 2008 |
| Credit Management Group UK (Merseyside) Ltd | Administrative & support | 2003 |
| Croft Automotive Group Ltd | Wholesale & retail | 2022 |
| Csons Leads Ltd | Transport & logistics | 2025 |
| CSP AV Limited | Administrative & support | 2018 |
| CTG Design Ltd | Administrative & support | 2013 |
| Cumpsty Medical Limited | Health & social care | 2025 |
| Curzon Park Chester Limited | Construction | 2014 |
| Cusco Engineering Limited | Professional & scientific | 2007 |
| Custom Clothing NW Ltd | Manufacturing | 2019 |
| Cyclonic Air Limited | Wholesale & retail | 2023 |
| D S Brickwork Northwest Ltd | Construction | 2016 |
| D. O. Design Services Limited | Professional & scientific | 2007 |
| D.S. Decorating Services Limited | Construction | 1993 |
| Dandlmac Associates Limited | Administrative & support | 2009 |
| Daniel OOI GP Services Limited | Health & social care | 2019 |
| Daniel Orme Design Ltd | Professional & scientific | 2022 |
| Danube Hospitality Ltd | Wholesale & retail | 2026 |
| Datamaster Services Limited | Construction | 2007 |
| Dave Roberts Engineering Services Limited | Professional & scientific | 2007 |
| David Neill Foods Limited | Wholesale & retail | 1998 |
| David Parkinson Electrical Design Limited | Administrative & support | 2008 |
| David Roberts Marine Limited | Transport & logistics | 2012 |
| DB IQ Limited | Administrative & support | 2026 |
| Dbml Limited | Real estate | 2022 |
| DC Properties (NW) Ltd | Extraterritorial | 2017 |
| Ddpd Limited | Real estate | 2019 |
| DEE Hills Park (Chester) Limited | Real estate | 2014 |
| DEE Refrigeration Limited | Wholesale & retail | 2019 |
| Dee-Hr Solutions Ltd | Information & communication | 2006 |
| Deepsea Technologies UK Limited | Manufacturing | 2005 |
| Defibuilder Enterprises Limited | Information & communication | 2024 |
| Delhaye Engineering Limited | Professional & scientific | 2011 |
| Demic Solutions Ltd | Administrative & support | 2026 |
| Design ABS Limited | Professional & scientific | 2015 |
| Design Integrated Ltd | Administrative & support | 2025 |
| Destinations DE Reve Limited | Professional & scientific | 2013 |
| Dhpm (UK) Limited | Information & communication | 2014 |
| Digital Logic Solutions Limited | Professional & scientific | 2010 |
| Digtech UK Limited | Construction | 2012 |
| Disc Electrical Ltd | Construction | 2008 |
| Dksc Limited | Administrative & support | 2010 |
| DL Holmes Ltd | Real estate | 2020 |
| DLH Parties Limited | Arts & recreation | 2015 |
| DNF Holdings Ltd | Professional & scientific | 2020 |
| Doggy Day Camp Limited | Other services | 2020 |
| Dogs Go Training Limited | Other services | 2024 |
| Dorward Visuals Limited | Professional & scientific | 2025 |
| Dovebrace Limited | Construction | 1985 |
| Dovepoint Building and Civil Engineering Limited | Construction | 2014 |
| Dovepoint Construction Ltd | Professional & scientific | 2011 |
| DPR HR Consultancy Limited | Professional & scientific | 2013 |
| DR Ella Limited | Health & social care | 2021 |
| DR Russell Austin Medico Legal Services Ltd | Administrative & support | 2015 |
| Dravin Engineering UK Limited | Professional & scientific | 2024 |
| Driftwood Marine Services Limited | Transport & logistics | 2012 |
| Drittoo Ltd | Education | 2014 |
| Dryhurst Facilities Management Limited | Administrative & support | 2018 |
| Dsbhr Limited | Wholesale & retail | 2014 |
| DT Teynor Property Limited | Real estate | 2017 |
| Dukeberry Ltd | Information & communication | 2016 |
| Dynamic Property Investors Limited | Real estate | 2017 |
| Easterly Maritime Services Limited | Transport & logistics | 2012 |
| Ec&I Project Engineering Ltd | Construction | 2013 |
| Eden IT Solutions Limited | Information & communication | 2008 |
| Elegant Engineering Solutions Limited | Professional & scientific | 2008 |
| Elite 857 Ltd | Other services | 2022 |
| Elltay's Ltd | Administrative & support | 2007 |
| EM People Limited | Administrative & support | 2010 |
| Embed Inclusion Limited | Education | 2022 |
| Eminent GRP Fabrications Limited | Construction | 2022 |