| Uronova Limited | Health & social care | 2026 |
| USA Sports Limited | Wholesale & retail | 2013 |
| VBV Interpreting Services Ltd | Professional & scientific | 2013 |
| Veracity Digital Limited | Administrative & support | 2011 |
| VFM 247 Ltd | Administrative & support | 2024 |
| Vinco People Solutions Ltd | Professional & scientific | 2014 |
| Vintage Franchising Ltd | Hospitality | 2023 |
| Vintage Top Co Ltd | Financial services | 2023 |
| Viridian Renewable Energy (Byley) Limited | Administrative & support | 2016 |
| Viridian Renewable Energy Limited | Administrative & support | 2014 |
| Virtue Venues Limited | Real estate | 2024 |
| Vision Developments (North West) Limited | Professional & scientific | 2008 |
| Vision Developments Two Ltd | Real estate | 2017 |
| Vision Investments One Ltd | Real estate | 2015 |
| Vision Investments Three Ltd | Real estate | 2016 |
| Vision Rail Limited | Administrative & support | 2014 |
| VOI Vino One Limited | Hospitality | 2026 |
| VRB Construction Ltd | Construction | 2025 |
| VSD Construction Engineering Limited | Professional & scientific | 2014 |
| VZB Investments Limited | Real estate | 2024 |
| Wainwrights Limited | Professional & scientific | 1993 |
| Waterfront Property Services Limited | Real estate | 2001 |
| Waterlily Productions Limited | Information & communication | 2015 |
| Wernham Investments Limited | Real estate | 2019 |
| West Derby Decorators Limited | Construction | 2019 |
| Westminster Packing Co. Ltd. | Manufacturing | 1993 |
| Westminster Plastics Ltd | Professional & scientific | 2002 |
| WFB Lettings Ltd | Households | 2025 |
| Wheeliebin Solutions Limited | Professional & scientific | 2019 |
| Whieldon and Forrester Limited | Professional & scientific | 2023 |
| Wholesale Flooring NW Ltd | Wholesale & retail | 2016 |
| Wholesale Signs Ltd | Wholesale & retail | 2018 |
| WHY Mediate Limited | Professional & scientific | 2014 |
| Wigshaw Engineering Limited | Administrative & support | 2012 |
| Wiksot Solutions Limited | Administrative & support | 2010 |
| Willaston Physiotherapy Limited | Administrative & support | 2012 |
| Wilsum Ltd | Wholesale & retail | 2025 |
| Wines of Italy Limited | Administrative & support | 1998 |
| Winleafe Limited | Manufacturing | 1984 |
| Wirral & Chester Taekwondo Ltd | Arts & recreation | 2010 |
| Wirral Car and Engineering Services Limited | Professional & scientific | 1964 |
| Wirral Community Narrowboat Trust | Transport & logistics | 1999 |
| Wirral Deluxe Cleaning Ltd | Administrative & support | 2012 |
| Wirral Electrical Ltd | Construction | 2019 |
| Wirral Equine Veterinary Practice Ltd | Professional & scientific | 2025 |
| Wirral Heating Solutions Ltd | Construction | 2020 |
| Wirral Locum and Consultancy Services Ltd | Professional & scientific | 2022 |
| Wirral Piping Fabs Ltd | Manufacturing | 2026 |
| Wirral Wildlife Landscaping Ltd | Administrative & support | 2024 |
| WLG Chester Limited | Administrative & support | 2007 |
| Woodland NW Developments Limited | Construction | 2018 |
| Woodway Court Management Company Ltd | Households | 2016 |
| Workwise Occupational Health Ltd | Health & social care | 2014 |
| World of Exotics Ltd | Wholesale & retail | 2020 |
| Wqccoordinations Ltd | Professional & scientific | 2019 |
| WTH Medical Limited | Health & social care | 2026 |
| WTS Systems Ltd | Information & communication | 2010 |
| XES Solutions Ltd | Professional & scientific | 2023 |
| Yaktien Medical Limited | Health & social care | 2017 |
| Zobra Asset Management Limited | Professional & scientific | 2016 |