| First Class Couriers Limited | Transport & logistics | 2024 |
| First Class Interiors Limited | Construction | 2001 |
| First Companion Care Ltd | Health & social care | 2021 |
| First Contemporary Limited | Wholesale & retail | 2010 |
| First Corporate Consultants Ltd | Administrative & support | 1987 |
| First Corporate Holdings Limited | Financial services | 2001 |
| First Corporate Law Services Limited | Extraterritorial | 1997 |
| First Corporate Shipping Limited | Other services | 1990 |
| First Direct Properties Ltd | Households | 2021 |
| First Director Limited | Extraterritorial | 2000 |
| First Flight Ballooning Ltd | Transport & logistics | 2024 |
| First FLO Accounting Ltd | Professional & scientific | 2022 |
| First Focus Group Ltd | Other services | 2022 |
| First FOX Architecture Ltd | Professional & scientific | 2011 |
| First Friends Mangotsfield Ltd | Health & social care | 2011 |
| First Key Home Limited | Education | 2026 |
| First Light Events Limited | Arts & recreation | 2019 |
| First Light Pianos Ltd | Manufacturing | 2024 |
| First Management Services Limited | Professional & scientific | 2000 |
| First National Corporate Services Limited | Extraterritorial | 1997 |
| First Orion UK Limited | Information & communication | 2015 |
| First Priorities PPP Health Services Limited | Construction | 2003 |
| First Quality Foods Limited | Professional & scientific | 2004 |
| First Response Healthcare Training Limited | Education | 2009 |
| First Secretary Limited | Extraterritorial | 1998 |
| First Step CNS Property Limited | Real estate | 2026 |
| First Step Homes (Wessex) Limited | Construction | 2012 |
| First Step PRE School Limited | Education | 2006 |
| First Thought Vans Limited | Wholesale & retail | 2020 |
| First Tide Ltd | Other services | 2017 |
| First West of England Limited | Transport & logistics | 1887 |
| Firstaspect Limited | Real estate | 1982 |
| Firstbid Limited | Real estate | 2004 |
| Firstgens C.I.C. | Education | 2024 |
| Firsthand Collective Ltd | Arts & recreation | 2025 |
| Firstm Limited | Information & communication | 1996 |
| Firstpoint Logistics Ltd | Information & communication | 2004 |
| Firststop Rail Solutions Limited | Real estate | 2001 |
| Firstsure Limited | Professional & scientific | 1996 |
| First_Pass Automation Limited | Manufacturing | 2006 |
| Firth Consultants Limited | Other services | 2007 |
| Fish 'N' FRY Ltd | Hospitality | 2023 |
| Fish 4 Life Ltd | Extraterritorial | 2016 |
| Fish and Meze Ltd | Hospitality | 2023 |
| Fish Bar 96 Limited | Hospitality | 2017 |
| Fish Cellars Management Limited | Real estate | 2006 |
| Fish Cellars Management Services Limited | Households | 2021 |
| Fish Computing Limited | Administrative & support | 2003 |
| Fish Formworks Limited | Construction | 2004 |
| Fish Kabab & Pizza Ltd | Hospitality | 2025 |
| Fish Supplies Online Limited | Professional & scientific | 2006 |
| Fisher & Dean Construction Limited | Construction | 2017 |
| Fisher Bailey Developments Ltd | Construction | 2020 |
| Fisher FIX Dogs Limited | Education | 2017 |
| Fisher Property Investments Limited | Real estate | 2019 |
| Fisher-Cooke Travel Limited | Transport & logistics | 2014 |
| Fishernaut Games Ltd | Information & communication | 2025 |
| Fishers (Bristol) Ltd | Hospitality | 2013 |
| Fishken Ltd | Professional & scientific | 2015 |
| Fishonroad Ltd | Hospitality | 2026 |
| Fishponds (SJS) Limited | Administrative & support | 2011 |
| Fishponds Cars Ltd | Wholesale & retail | 2019 |
| Fishponds Catering Limited | Hospitality | 2025 |
| Fishponds Convenience Store Ltd | Wholesale & retail | 2020 |
| Fishponds Excavations Limited | | 1975 |
| Fishponds Fish Bar Ltd | Hospitality | 2025 |
| Fishponds Locality Action Group Limited | Health & social care | 2003 |
| Fishponds Ltd | Wholesale & retail | 2025 |
| Fishponds Road Homes Ltd | Construction | 2017 |
| Fishtank Recruitment Limited | Administrative & support | 2026 |
| Fisk & Frites Ltd | Hospitality | 2024 |
| Fiskfrite Bristol Limited | Hospitality | 2025 |
| Fistful of Yuan Ltd | Wholesale & retail | 2026 |
| Fit for Life Training Limited | Other services | 2002 |
| Fit Faces Academy Ltd | Wholesale & retail | 2026 |
| Fit Installation Ltd | Construction | 2022 |
| Fit Like ADA Ltd | Professional & scientific | 2023 |
| Fitfollow Limited | Professional & scientific | 1986 |
| Fitness for Life Limited | Arts & recreation | 2020 |
| Fitness Worx Bristol Ltd | Arts & recreation | 2020 |
| Fitnessbros Ltd | Wholesale & retail | 2024 |
| Fitnessbydesign(.Org.Uk) Ltd | Arts & recreation | 2013 |
| Fitnessndiets.Com Ltd | Arts & recreation | 2000 |
| Fitpreneur Ltd | Administrative & support | 2023 |
| Fitquest Health and Fitness Ltd | Other services | 2014 |
| Fitsall Properties Limited | Real estate | 2025 |
| Fittwithfran Limited | Arts & recreation | 2026 |
| Fitz CX Consultancy Ltd | Administrative & support | 2024 |
| Fitz Stoves UK Ltd | Construction | 2022 |
| Fitz Woodburners Limited | Construction | 2016 |
| Fitzbean Properties Limited | Real estate | 2025 |
| Fitzfield Administration and Management Services Limited | Professional & scientific | 2002 |
| Fitzgerald Group Holdings Ltd | Real estate | 2017 |
| Fitzgerald Property Services Ltd | Real estate | 2016 |
| Fitzroys Developments Limited | Real estate | 2012 |
| Five Acre Farm CIC | Agriculture & fishing | 2023 |
| Five Ashley Court Road Management Limited | Households | 1988 |
| Five Bakers Ltd | Construction | 2019 |
| Five Days Limited | Professional & scientific | 2012 |
| Five Delta Limited | Construction | 2019 |