| Design & Tonic Limited | Professional & scientific | 2012 |
| Design + Prototype Ltd | Professional & scientific | 2013 |
| Design 4 Life Limited | Administrative & support | 2009 |
| Design 4 Life Property Limited | Real estate | 2016 |
| Design and Build Resource Solutions Ltd | Administrative & support | 2009 |
| Design Build Solutions Ltd | Professional & scientific | 2016 |
| Design by Boola Ltd | Professional & scientific | 2013 |
| Design Chem Limited | Professional & scientific | 2026 |
| Design Coordination & Management Ltd. | Professional & scientific | 2012 |
| Design Driven Solutions Ltd | Professional & scientific | 2023 |
| Design Flooring Ltd. | Construction | 1998 |
| Design for X Ltd | Professional & scientific | 2009 |
| Design MAP London Limited | Professional & scientific | 2005 |
| Design Militia Ltd | Information & communication | 2008 |
| Design Online Limited | Wholesale & retail | 2020 |
| Design Plus Media Limited | Construction | 2008 |
| Design Rally Ltd | Professional & scientific | 2015 |
| Design Resource (UK) Limited | Professional & scientific | 2009 |
| Design Scaffolding (Holdings) Limited | Financial services | 2019 |
| Design Seven Ltd | Construction | 2024 |
| Design Southwest Construction Ltd | Construction | 2025 |
| Design Sprint Experts Ltd | Professional & scientific | 2022 |
| Design Survey Sales Ltd | Professional & scientific | 2018 |
| Design West Trading Limited | Hospitality | 2022 |
| Design-Masters Ltd | Professional & scientific | 2021 |
| DESIGN146 Limited | Administrative & support | 2006 |
| DESIGNCO2 Ltd | Information & communication | 2012 |
| Designed Life Collective Ltd | Professional & scientific | 2023 |
| Designed Life Stays Ltd | Real estate | 2018 |
| Designer Lawns Limited | Administrative & support | 2016 |
| Designer Outlet Fruit Limited | Wholesale & retail | 2026 |
| Designers / Makers Ltd | Wholesale & retail | 2012 |
| Designpro Ltd | Professional & scientific | 2025 |
| Designqueue Limited | Administrative & support | 1998 |
| Designrite Limited | Real estate | 1984 |
| Designz (Lettings) Limited | Real estate | 2019 |
| Desina Limited | Wholesale & retail | 2025 |
| Desirable Care Ltd | Other services | 2016 |
| Desired Training Ltd | Administrative & support | 2022 |
| Desis Organise CIC | Hospitality | 2021 |
| Deskhopper Ltd | Real estate | 2017 |
| Desklodge Ltd | Hospitality | 2007 |
| Desktop Dojo Ltd | Information & communication | 2019 |
| Desktop Enterprises Limited | Information & communication | 2010 |
| Desmotech Ltd | Professional & scientific | 2021 |
| Desperate MEN Ltd | Arts & recreation | 2005 |
| Destination 5 Limited | Construction | 2010 |
| Destination Express Limited | Transport & logistics | 2025 |
| Destination Plymouth Limited | Administrative & support | 2010 |
| Destiny Care Ltd | Health & social care | 2013 |
| Desynit Limited | Information & communication | 2007 |
| DET Community CIC | Arts & recreation | 2023 |
| Detail Building & Carpentry Services Limited | Construction | 2013 |
| Detail Developments Limited | Construction | 2007 |
| Detailed Solutions Limited | Administrative & support | 2023 |
| Detect Data Ltd | Information & communication | 2024 |
| Detect Fire and Security South West Ltd | Administrative & support | 2024 |
| Detodo Ltd | Wholesale & retail | 2022 |
| Detox Holdings Limited | Professional & scientific | 2025 |
| Deus Properties Ltd | Real estate | 2025 |
| Deutsche Car Ltd | Wholesale & retail | 2016 |
| DEV Bristol Limited | Wholesale & retail | 2023 |
| DEV Sky Limited | Wholesale & retail | 2020 |
| Devcybersec Ltd | Information & communication | 2026 |
| Develeco Limited | Construction | 2004 |
| Develop at Work Ltd | Professional & scientific | 2024 |
| Develop Bristol Ltd | Construction | 2018 |
| Develop This Ltd | Construction | 2019 |
| Developerfy Limited | Information & communication | 2024 |
| Developing Moves Ltd | Education | 2025 |
| Development Land Holdings PLC | Professional & scientific | 2005 |
| Developments Bristol Ltd | Administrative & support | 2017 |
| Developments by US Limited | Real estate | 2018 |
| Developments One Ltd | Financial services | 2015 |
| Developpez Ltd | Information & communication | 2006 |
| Deveron Advisory Limited | Financial services | 2018 |
| Deversorium Ltd | Other services | 2026 |
| Devex Commerce LP | | 2012 |
| Device Scope Ltd | Manufacturing | 2013 |
| Deviens Entrepreneur.E Ltd | Other services | 2018 |
| Devig Tamu Limited | Real estate | 2025 |
| Devika Sharma Ltd | Real estate | 2018 |
| Devizes (Marshall Road) Management Company Limited | Households | 2025 |
| Devlnd E-Commerce Ltd | Wholesale & retail | 2022 |
| Devlnd Fulfilment Ltd | Wholesale & retail | 2022 |
| Devlnd Limited | Wholesale & retail | 2015 |
| Devon & Cornwall Investigations Limited | Administrative & support | 2025 |
| Devon Bay Adjusting Limited | Financial services | 2023 |
| Devon Bay Solutions Limited | Financial services | 2023 |
| Devon Bell Tent Hire Ltd | Extraterritorial | 2024 |
| Devon Commercial Stationers Limited | Wholesale & retail | 2001 |
| Devon Gardener Properties Ltd | Real estate | 2023 |
| Devon House Estates Limited | Real estate | 1998 |
| Devon Luxe Stays Ltd | Real estate | 2025 |
| Devon Smiles Limited | Health & social care | 2010 |
| Devon Ultrasound Limited | Health & social care | 2016 |
| Devon Wellness Co Limited | Financial services | 2013 |
| Devotion Limited | Hospitality | 1983 |
| Devsco Consulting Ltd | Professional & scientific | 2025 |
| DEW Developments Ltd | Real estate | 2018 |