| Seabirdbridlington Ltd | Hospitality | 2025 |
| Seabirds Bridlington Ltd | Hospitality | 2025 |
| Seafront Apartments Bridlington Ltd | Real estate | 2019 |
| Seagulls Cabins Ltd | Hospitality | 2010 |
| Seagulls Chalets Ltd | Hospitality | 2010 |
| Seal and Pump Engineering (U.K) Limited | Manufacturing | 2006 |
| Seamer Properties Limited | Professional & scientific | 2014 |
| Seascape (Bridlington) Limited | Hospitality | 2019 |
| Seaside Escapes Bridlington Ltd | Hospitality | 2024 |
| Seaside Pies Ltd | Hospitality | 2025 |
| Seaside Rock & Gifts Limited | Wholesale & retail | 2011 |
| Seaton Rail Limited | Administrative & support | 2008 |
| Secova Ltd | Wholesale & retail | 2024 |
| Select Foods Limited | Wholesale & retail | 2002 |
| Sellers Holdings 2025 Ltd | Financial services | 2025 |
| Service&Trade Limited | Wholesale & retail | 2022 |
| Services Surplus Limited | Wholesale & retail | 2014 |
| Services&Trade Limited | Wholesale & retail | 2022 |
| Sewerby Grange Limited | Real estate | 2018 |
| Sewerby Stores Ltd | Wholesale & retail | 2025 |
| Shades of Hair Limited | Other services | 2006 |
| Shannon Fishing Company Bridlington Limited | Agriculture & fishing | 2012 |
| Sharinder's H & C Limited | Wholesale & retail | 2023 |
| Sheffield Pro Golf Limited | Wholesale & retail | 2012 |
| Shields(Driffield) Ltd. | Manufacturing | 2003 |
| Shimms Limited | Manufacturing | 2020 |
| Ship Inn Flamborough Limited | Hospitality | 2026 |
| Ship to Shore Fish Merchants Limited | Wholesale & retail | 2016 |
| Ship to Shore Holdings Limited | Financial services | 2024 |
| Shoebill Holdings Ltd | Financial services | 2026 |
| Shore Thing Bridlington Ltd | Hospitality | 2018 |
| Shoreline Apartments Ltd | Hospitality | 2020 |
| Shorewood Leisure Group Limited | Hospitality | 1990 |
| Shorewood Parks Limited | Hospitality | 2005 |
| Shorewood Resorts Limited | Extraterritorial | 2013 |
| Side Oven Limited | Manufacturing | 2017 |
| Sign & Designs Limited | Manufacturing | 2009 |
| Signature Apartments @ 52 Ltd | Hospitality | 2022 |
| Simmonsherriff LLP | | 2010 |
| Simply Kiddy Ltd | Wholesale & retail | 2022 |
| Site Weld Services Limited | Other services | 2021 |
| SIX Flats Victoria Road Limited | Professional & scientific | 2025 |
| SKIN@28 Ltd | Other services | 2024 |
| SKN Developments Limited | Real estate | 2011 |
| Skorri Consulting Limited | Financial services | 2014 |
| SKW Construction Ltd | Construction | 2019 |
| Skydive GB Parachute Club Ltd | Arts & recreation | 2020 |
| Skydiving Aircraft Ltd | Transport & logistics | 2014 |
| Skye Construct Limited | Professional & scientific | 2016 |
| Skye Property Group Limited | Construction | 2016 |
| Skyline Steel Engineering Limited | Extraterritorial | 2011 |
| Skylines Roofing Ltd | Construction | 2025 |
| SL Laundries Ltd | Other services | 2011 |
| Slush Factory (Bridlington) Ltd | Wholesale & retail | 2019 |
| Slushcup Limited | Hospitality | 2017 |
| SMD Solutions (Yorks) Ltd | Information & communication | 2024 |
| Snainton Golf Centre Limited | Arts & recreation | 1999 |
| Snainton Golf Properties Limited | Real estate | 2017 |
| Social Video Studio Limited | Information & communication | 2022 |
| Soha Group Ltd | Hospitality | 2025 |
| Solderking Assembly Materials Limited | Manufacturing | 2018 |
| Solvang Medical Limited | Health & social care | 2019 |
| Sophie Cook Ltd | Wholesale & retail | 2025 |
| Sophisticutz Limited | Other services | 2006 |
| Soran Qadir Limited | Other services | 2020 |
| South 16 Ltd | Hospitality | 2023 |
| South Marine Point Owners Limited | Real estate | 2011 |
| Southfield Storage Ltd | Real estate | 2023 |
| Spa Retreats Limited | Real estate | 2022 |
| Sparkle & Shine (Services) Limited | Administrative & support | 2016 |
| Sparta Networks Limited | Information & communication | 2011 |
| Specstudio Limited | Professional & scientific | 2021 |
| Spectech Studio Limited | Information & communication | 2025 |
| Speed 9861 Limited | Construction | 2004 |
| Sphere Griffin Limited | Information & communication | 2004 |
| Sporomex Limited | Health & social care | 2002 |
| Springhead Chiropody and Podiatry Limited | Health & social care | 2020 |
| Springvale Homes (East Yorkshire) Limited | Construction | 2007 |
| SRL Composites Ltd | Manufacturing | 2024 |
| ST Johns Avenue (Bridlington) Limited | Households | 2022 |
| ST Marys (ASC) Limited | Health & social care | 2017 |
| ST Marys (Chanterlands) Ltd | Health & social care | 2021 |
| ST Marys (County Durham) Ltd | Administrative & support | 2021 |
| ST Marys (North Yorkshire) Ltd | Construction | 2021 |
| ST Marys Care Services Ltd | Administrative & support | 2020 |
| Stamp Studios Ltd | Manufacturing | 2025 |
| Stanley Charles Property Limited | Real estate | 2015 |
| Stars & Brackets Limited | Financial services | 2025 |
| Startronix Limited | Arts & recreation | 2018 |
| Station Avenue Pharmacy Limited | Wholesale & retail | 1999 |
| Staywarm Energy Grants Ltd | Construction | 2023 |
| Stella Gill Developments Limited | Financial services | 2025 |
| Stella Gill Investments Limited | Financial services | 2025 |
| Stella Gill North Limited | Construction | 2025 |
| Stella Gill South Limited | Construction | 2025 |
| Stenergy Property Ltd | Real estate | 2025 |
| Stephen Creed Ltd | Hospitality | 2025 |
| Stephen Greaves Designs Ltd | Professional & scientific | 2022 |
| Steve and BEA Ryan Limited | Construction | 2021 |
| Steve Bowling Food Consultant Limited | Administrative & support | 2015 |