| Shrops Hire Solutions Limited | Administrative & support | 2014 |
| Shropshire Church of England Academies Trust | Education | 2024 |
| Shropshire Cleaning Solutions Limited | Administrative & support | 2018 |
| Shropshire Colour Rend Ltd | Construction | 2022 |
| Shropshire Falconry Limited | Other services | 2016 |
| Shropshire Financial Healthcare Consulting Ltd | Professional & scientific | 2025 |
| Shropshire Lodges Ltd | Hospitality | 2018 |
| Shropshire Tiny Homes Limited | Manufacturing | 2020 |
| Sifagos Consultancy Limited | Professional & scientific | 2014 |
| Signature Pools and Spa Ltd | Construction | 2024 |
| Simon Whitmore Ltd | Information & communication | 2017 |
| Simple Franchise Solutions Ltd | Information & communication | 2020 |
| Simplytap Ltd | Information & communication | 2023 |
| Sisley Vehicle Contracts Limited | Real estate | 1987 |
| Sitec Solutions Ltd | Information & communication | 2007 |
| SIX Ashes Studio Ltd | Information & communication | 2011 |
| SJE Accounting Services Limited | Professional & scientific | 2013 |
| Skippers (Highley) Fish Bar Ltd | Hospitality | 2020 |
| Sky High Clothings Ltd | Wholesale & retail | 2024 |
| Skyline Safety Limited | Professional & scientific | 1995 |
| SL Vehicle Logistics Limited | Transport & logistics | 2025 |
| Sladen Associates Limited | Professional & scientific | 2002 |
| Sladen Partnership Limited | Professional & scientific | 2002 |
| Slide Away (UK) Ltd | Manufacturing | 2011 |
| Sliver Engineering Solutions Ltd | Professional & scientific | 2019 |
| Smallman Hall Classic Cars Ltd | Wholesale & retail | 2021 |
| Smallwood Property Investments Ltd | Real estate | 2023 |
| Smart Space Online Ltd | Manufacturing | 2017 |
| Smart Tank UK Limited | Manufacturing | 2002 |
| Smba Consulting Limited | Administrative & support | 2023 |
| Smirk Limited | Hospitality | 2023 |
| Smith and Jones Engineering Limited | Manufacturing | 2010 |
| SNG Group Limited | Manufacturing | 1998 |
| Snow Projects Limited | Professional & scientific | 2013 |
| Snowdrop Home Care Ltd | Health & social care | 2018 |
| Solar Electronics Limited | Wholesale & retail | 1998 |
| Solar Property Management Limited | Real estate | 2010 |
| Solar-Shield Exterior Shading Solutions Limited | Extraterritorial | 2022 |
| Solartec Products Limited | Wholesale & retail | 2016 |
| South Coast Land, Planning and Development Ltd | Real estate | 2015 |
| South Shropshire Properties Limited | Real estate | 2021 |
| Southall Bank Farm (Management) Company Limited | Professional & scientific | 1989 |
| Southgate Healthcare Limited | Extraterritorial | 2010 |
| Southorn Court (Broseley) Management Company Limited | Real estate | 2000 |
| SPD Lettings Ltd | Real estate | 2019 |
| Specialist Tool Hire Ltd. | Administrative & support | 2017 |
| Spectrum Luminaires Limited | Manufacturing | 1985 |
| Speke Properties Portfolio One Ltd | Real estate | 2026 |
| Speke Properties Portfolio Two Ltd | Real estate | 2026 |
| Speronella Marsh Limited | Professional & scientific | 2024 |
| Spice House MSA Limited | Hospitality | 2025 |
| Spinhope Ltd | Information & communication | 2011 |
| Split Rings Limited | Professional & scientific | 1982 |
| Sports 4 U Limited | Arts & recreation | 2004 |
| Sprint Couriers Ltd | Transport & logistics | 2006 |
| Sstyresolutions Limited | Wholesale & retail | 2026 |
| ST. Johns Court (Bridgnorth) Management Company Limited | Real estate | 2006 |
| Stable Designs Limited | Professional & scientific | 2008 |
| Stageready Academy Ltd | Arts & recreation | 2025 |
| Stand Firm Analytics Ltd | Public administration | 2022 |
| Staneford Ventures Ltd | Financial services | 2026 |
| Stanton Ralph & Co Limited | Professional & scientific | 2014 |
| Stanton Ralph Property Limited | Financial services | 2022 |
| Staysafe PPE Limited | Water & waste | 2016 |
| Stealth Solutions Limited | Administrative & support | 2016 |
| Steed Architecture & Interiors Limited | Professional & scientific | 2014 |
| Steve Fellows Road Haulage Services Limited | Transport & logistics | 2012 |
| Steve Morris & Co Limited | Wholesale & retail | 1982 |
| Steve Russell Golf Limited | Arts & recreation | 2012 |
| STF Praedium Limited | Real estate | 2021 |
| STF Storage Ltd | Transport & logistics | 2020 |
| Stinky Ink.Com Limited | Wholesale & retail | 2011 |
| Stitches of Bridgnorth Limited | Wholesale & retail | 2008 |
| Stonefield West Ltd | Construction | 2023 |
| Storagebox Ltd | Real estate | 2022 |
| Stourport Caravan Sales Limited | Wholesale & retail | 2020 |
| Straightline Aviation Limited | Transport & logistics | 2015 |
| Strategic Advocacy Solutions Ltd | Administrative & support | 2025 |
| Strategic Leisure Limited | Professional & scientific | 2011 |
| Stretton Park Estates Limited | Hospitality | 2012 |
| Stuart Sherwood Limited | Construction | 2008 |
| Studio Beau Ltd | Other services | 2020 |
| Studio Wellness & Fitness Limited | Arts & recreation | 2025 |
| Subpro UK Limited | Wholesale & retail | 2020 |
| Sudbury Decorating Services Limited | Construction | 2016 |
| Suitehuts Accommodation Limited | Hospitality | 2024 |
| Superclean (Wolverhampton) Limited | Households | 1995 |
| Suttons & SON Caravan Storage Ltd | Transport & logistics | 2025 |
| Suttons & SON Container Storage Ltd | Transport & logistics | 2025 |
| Suttons & SON Limited | Agriculture & fishing | 2023 |
| Svenn Consultancy Limited | Information & communication | 2014 |
| Swan Farm Studios Ltd | Professional & scientific | 2013 |
| Swansea Flight Centre Ltd | Transport & logistics | 2026 |
| SWC (UK) Ltd | Other services | 2012 |
| SWC Property Investments Ltd | Real estate | 2019 |
| Sweaft Limited | Transport & logistics | 2023 |
| Sweatbox Official Limited | Arts & recreation | 2025 |
| Switchnet Solutions Ltd | Information & communication | 2026 |
| Symeco Ltd | Professional & scientific | 2010 |
| Synchro CNC Limited | Construction | 2004 |