| Sharevision Ltd | Information & communication | 2020 |
| Sharisard a Ltd | Administrative & support | 2021 |
| Sharisard B Ltd | Administrative & support | 2022 |
| Sharisard C Ltd | Administrative & support | 2022 |
| Sharma Investments & Holdings Ltd | Real estate | 2023 |
| Shaun Derrick Coaching Ltd | Arts & recreation | 2026 |
| Shaun Gordon Ltd | Wholesale & retail | 2018 |
| Sheepish Software Ltd | Information & communication | 2025 |
| Sheld & Co Ltd | Professional & scientific | 2018 |
| Shell E-Commerce Ltd | Administrative & support | 2023 |
| Shepherds Media Academy CIC | Information & communication | 2025 |
| Shery London Ltd | Manufacturing | 2024 |
| Shiba Short Lets Limited | Real estate | 2023 |
| Shilton Bidco Limited | Professional & scientific | 2017 |
| Shilton Holdco Limited | Professional & scientific | 2017 |
| Shine Cleaning Ltd | Administrative & support | 2008 |
| Shiraz BBQ & Grill Ltd | Hospitality | 2025 |
| Shishatoyours Ltd | Hospitality | 2020 |
| Shivom Consultancy Limited | Information & communication | 2003 |
| Shivom Holdings Limited | Financial services | 2022 |
| Shivom Investments Ltd | Real estate | 2018 |
| Shokizm Interactive Ltd | Information & communication | 2017 |
| Shopifyhunter Ltd | Wholesale & retail | 2024 |
| Shopsight Ltd | Wholesale & retail | 2025 |
| Shree Vaikuntam Technologies Limited | Information & communication | 2013 |
| Shreewiz Consultants Limited | Professional & scientific | 2017 |
| Shri Radhe Krishna Limited | Hospitality | 2025 |
| Shruthifastfoods Ltd | Hospitality | 2024 |
| Shurouk Academy Ltd | Education | 2024 |
| Sialia Corporations Ltd | Financial services | 2026 |
| Siar Consulting Ltd | Professional & scientific | 2023 |
| Sidebyside Property Ltd | Households | 2025 |
| Sidmouth Repertory Theatre CIC | Arts & recreation | 2026 |
| Sidra Suites Ltd | Hospitality | 2025 |
| Sienna Commercial Asset Group Limited | Real estate | 2026 |
| Sienna Real Estate (Canterbury) Limited | Real estate | 2023 |
| Sienna Real Estate (Darlington) Limited | Administrative & support | 2025 |
| Sienna Real Estate (Leamington Spa) Limited | Administrative & support | 2026 |
| Sienna Real Estate (Southwark) Limited | Real estate | 2026 |
| Sienna Real Estate Ltd | Real estate | 2012 |
| Sigel Enterprises Limited | Wholesale & retail | 2022 |
| Signature Sound Production Ltd | Information & communication | 2019 |
| Signitive AI Ltd | Information & communication | 2022 |
| Silicon Glen Embedded Solutions (Sges) Limited | Manufacturing | 2024 |
| Silver Coin (UK) Limited | Wholesale & retail | 2013 |
| Silver Star Shoppe Limited | Manufacturing | 2025 |
| Simber Limited | Wholesale & retail | 2019 |
| Simmo's (Billingsgate) Limited | Wholesale & retail | 1989 |
| Simon Inc Ltd | Professional & scientific | 2010 |
| Simple Global Group Ltd | Information & communication | 2025 |
| Simran Collections Limited | Wholesale & retail | 2011 |
| Sinagtala Ltd | Professional & scientific | 2025 |
| Sinkove Limited | Information & communication | 2024 |
| Sintons Carpentry & Construction Ltd | Manufacturing | 2023 |
| Sippre Ltd | Wholesale & retail | 2026 |
| Siracusa Brentford Limited | Hospitality | 2011 |
| Sisi.Cleaning Limited | Administrative & support | 2016 |
| SIU Prop Ltd | Real estate | 2021 |
| SIX Italian Food T/A L'Antica Pizzeria DA Michele Ltd | Hospitality | 2017 |
| SIX Stairs Ltd | Manufacturing | 2023 |
| SK Cloud Technologies and Consulting Ltd | Information & communication | 2018 |
| SK Holding Services Limited | Real estate | 2025 |
| SK Toor & Partners Limited | Real estate | 2022 |
| Skbg Limited | Information & communication | 2021 |
| SKE Property Ltd | Real estate | 2019 |
| Skill Hospitality Consultants Ltd | Professional & scientific | 2025 |
| Skill Nova Ltd | Professional & scientific | 2024 |
| Skillhive Workforce Solutions Ltd | Administrative & support | 2025 |
| Skippity HOP Limited | Information & communication | 2011 |
| SKL Leisure Ltd | Hospitality | 2026 |
| SKS Brothers Ltd | Wholesale & retail | 2026 |
| Skulpta Ltd | Wholesale & retail | 2017 |
| Sky Chaxer Limited | Financial services | 2023 |
| Sky Digital London Ltd | Professional & scientific | 2025 |
| Sky Little Angel Ltd | Wholesale & retail | 2026 |
| Sky Pharm Ltd | Wholesale & retail | 2019 |
| Sky SAT Communication UK Limited | Information & communication | 2023 |
| Skylark Hospitality (Covent Garden) Ltd | Hospitality | 2021 |
| SL3LNG Ltd | Hospitality | 2026 |
| Slice Tech Limited | Administrative & support | 2025 |
| Sloan Partners Ltd | Professional & scientific | 2021 |
| Small Ceramics Ltd | Manufacturing | 2022 |
| Smart Home Express Limited | Wholesale & retail | 2021 |
| Smart Point Marketing Ltd | Professional & scientific | 2020 |
| Smartech Global Enterprises Ltd | Wholesale & retail | 2023 |
| SMB Manufacturing Solutions Limited | Wholesale & retail | 2019 |
| Smiiyl Ltd | Wholesale & retail | 2025 |
| Smileevents Ltd | Administrative & support | 2024 |
| Smithkline Beecham-B Limited | Manufacturing | 1896 |
| SMS Future Ltd | Real estate | 2022 |
| SN Kavya Ltd | Administrative & support | 2015 |
| Snackd Ltd | Wholesale & retail | 2021 |
| Snakes and Ladders Adventure Centres Ltd | Arts & recreation | 1993 |
| SNW Holdings Limited | Financial services | 2021 |
| SO DO YOU Ltd | Wholesale & retail | 2026 |
| Social Nova Ltd | Professional & scientific | 2018 |
| Soedex Limited | Information & communication | 2024 |
| Soho Consulting Group Limited | Professional & scientific | 2021 |
| Solar Crews Limited | Construction | 2025 |
| Solid Woodworks Ltd | Construction | 2014 |