| Property Flux Packaging Ltd | Real estate | 2020 |
| Propscout UK Ltd | Real estate | 2023 |
| Protheroe Estates Ltd | Real estate | 2025 |
| PSYCH45 Limited | Health & social care | 2010 |
| Pure Aestheticsrs Ltd | Health & social care | 2021 |
| Purple Carrot Catering Limited | Hospitality | 2012 |
| Pwll Hydro Ltd | Energy | 2014 |
| Pythia Contracts Limited | Professional & scientific | 2012 |
| R & C Construction( Hereford) Ltd | Construction | 2025 |
| R & E Finlay Properties Limited | Real estate | 2002 |
| R & M Drinks Ltd | Hospitality | 2025 |
| R B Plant Ltd | Construction | 2021 |
| R B Plant Training Limited | Professional & scientific | 2018 |
| R M Drew Developments Limited | Construction | 2018 |
| R W Evans & SON Limited | Mining & quarrying | 2005 |
| R&K Giveaways Ltd | Other services | 2025 |
| R.W.W.Pantall Limited | Agriculture & fishing | 1959 |
| RAI and Sons Limited | Real estate | 2025 |
| Raiff Devlin Consulting Limited | Professional & scientific | 2024 |
| Railway Restaurant Limited | Hospitality | 2015 |
| RBJ Resource Ltd | Wholesale & retail | 2019 |
| Reading House Limited | Real estate | 2002 |
| Red Chair Design Studio Ltd | Professional & scientific | 2025 |
| Red Kite Health Solutions CIC | Health & social care | 2015 |
| Red Kite Investments Limited | Financial services | 1999 |
| Red Kite MTD Solutions Limited | Professional & scientific | 2019 |
| Redline Remaps and Keys Ltd | Other services | 2022 |
| Redsky Brecon Limited | Other services | 2022 |
| Remat Services Ltd | Construction | 2015 |
| Restore Balance Limited | Health & social care | 2015 |
| Rhiannydds Cottages Limited | Hospitality | 2023 |
| Rhymney Coal Co. Limited | Professional & scientific | 1980 |
| Rich & Sons Limited | Administrative & support | 2011 |
| Rich Landscapes Limited | Administrative & support | 2015 |
| RKC (Park Grounds) Limited | Construction | 2021 |
| RKC Projects Ltd | Professional & scientific | 2019 |
| RMH 88 Ltd | Hospitality | 2026 |
| RMJ Accountancy Ltd | Professional & scientific | 2023 |
| RMJ Homes Limited | Construction | 2012 |
| Roberts Building Consultants Ltd | Professional & scientific | 2004 |
| ROC Outdoor Adventure Ltd | Administrative & support | 2024 |
| Rodell & Jones Ltd. | Construction | 2012 |
| Rodell and John Holdings Ltd | Financial services | 2024 |
| Rodell Chimneys Limited | Manufacturing | 1969 |
| Rootkin Associates Limited | Agriculture & fishing | 1986 |
| Route 430 Limited | Construction | 2007 |
| Rupesh Property Solution Ltd | Real estate | 2024 |
| Ryan Jones Building Contractor Limited | Construction | 2019 |
| S & L Motors Brecon Limited | Manufacturing | 2012 |
| Sacred Nest Ltd | Wholesale & retail | 2020 |
| Safetywise Consultancy Ltd | Administrative & support | 2021 |
| Saho Property Development Ltd | Construction | 2024 |
| Saldar Limited | Hospitality | 2006 |
| SAM Viney Communications Limited | Other services | 2022 |
| Samantha Clifford Limited | Health & social care | 2007 |
| Samten Limited | Information & communication | 2017 |
| Sanderson Maughan Limited | Professional & scientific | 2003 |
| Sanjib Property Limited | Real estate | 2024 |
| Sarah Siddons Brecon Ltd | Hospitality | 2018 |
| Scaffolding Services DOT COM Ltd. | Construction | 2013 |
| Scaffolding Services Group Ltd | Construction | 2025 |
| Scout Edge Analytics Ltd | Information & communication | 2024 |
| Scout.Edge.Analytics. Dragons Ltd | Information & communication | 2024 |
| Seer Civils Limited | Construction | 2026 |
| Seer Construction Limited | Construction | 2009 |
| Seer Group Holdings Limited | Financial services | 2026 |
| Seer Plant Hire Limited | Administrative & support | 2026 |
| Select Products Limited | Manufacturing | 1994 |
| Sennybridge Farmers Hunt Ltd | Professional & scientific | 2025 |
| Sennybridge Service Station Limited | Wholesale & retail | 2003 |
| Sennybridge Shepherds Huts and Glamping Limited | Construction | 2019 |
| Sensato Ltd | Professional & scientific | 2010 |
| Sherpa Ventures Limited | Wholesale & retail | 2023 |
| Silk Road Adventures Ltd | Administrative & support | 2015 |
| Silurian Energy Ltd | Agriculture & fishing | 2011 |
| Silver Assist Homecare Limited | Health & social care | 2022 |
| Simon Henderson Research Limited | Administrative & support | 2017 |
| Sinnrg Ltd | Wholesale & retail | 2025 |
| Sizawena Ltd | Health & social care | 2019 |
| SJ Conveyors Ltd | Manufacturing | 2026 |
| Sleepy Stayz Ltd | Real estate | 2026 |
| Slsp Group Ltd | Real estate | 2023 |
| SMA Driver Training Limited | Education | 2016 |
| Smithy Blacks Limited | Manufacturing | 2025 |
| Sniper Solutions International Ltd | Education | 2014 |
| Solar Gate Systems Limited | Manufacturing | 2016 |
| Sophie Box Legal Services Ltd. | Professional & scientific | 2023 |
| Soteria Chauffeurs and Security Ltd | Transport & logistics | 2018 |
| South Wales Outdoor Activity Providers Group | Education | 2018 |
| South Wales Scaffolding Services Limited | Construction | 2012 |
| Southern Cross Business Coaching Ltd | Professional & scientific | 2018 |
| Southgate Commercial (Porth) Limited | Real estate | 2014 |
| Spirejet Aerocharter Limited | Transport & logistics | 2024 |
| Splonk Limited | Information & communication | 2024 |
| Springvale Property Developments Ltd | Construction | 2015 |
| Springvale Property Management Ltd | Real estate | 2015 |
| SR Morris Ltd | Real estate | 2025 |
| SRI Radha Limited | Real estate | 2023 |
| SSR Business Ltd | Hospitality | 2026 |
| St.Reathams (Restaurant & Bar) Limited | Hospitality | 2011 |