| Sawrey Apartments Ltd | Real estate | 2021 |
| Saxon Glazing Limited | Manufacturing | 2023 |
| Saya DXB Ltd | Wholesale & retail | 2018 |
| Saya Play Ltd | Wholesale & retail | 2026 |
| Sayahk Limited | Health & social care | 2020 |
| Sayeeds of Company Ltd | Wholesale & retail | 2025 |
| Sayf Interior Blinds Ltd | Wholesale & retail | 2021 |
| Sazuma Global Limited | Wholesale & retail | 2024 |
| SB Birmingham Limited | Hospitality | 2026 |
| SB Logistics Group Ltd | Transport & logistics | 2021 |
| SB Merchants House (London) Limited | Real estate | 2013 |
| SB Norfolk Properties Ltd | Real estate | 2018 |
| SB Propco Ltd | Real estate | 2024 |
| SB Property Yorkshire Ltd | Real estate | 2021 |
| SB Recovery & Rescue Ltd | Wholesale & retail | 2023 |
| SB Siblings Limited | Wholesale & retail | 2020 |
| SB Supplies Yorkshire Limited | Hospitality | 2026 |
| SB Therapy Ltd | Health & social care | 2019 |
| SB Training Ltd | Education | 2022 |
| SB Transport (London) Limited | Transport & logistics | 2024 |
| SB Vehicle Logistics Limited | Transport & logistics | 2024 |
| SB Yorks Ltd | Hospitality | 2026 |
| SB77 Ltd | Hospitality | 2023 |
| SBE Ventures Limited | Wholesale & retail | 2024 |
| SBK Consultancy Ltd | Health & social care | 2024 |
| SBL Group (BFD) Ltd | Transport & logistics | 2024 |
| SBN Services Limited | Professional & scientific | 2022 |
| SBO Estates Ltd | Real estate | 2025 |
| SBP2000 Limited | Real estate | 2025 |
| SBS (MCR) Limited | Construction | 2023 |
| SBS Consultants Ltd | Professional & scientific | 2024 |
| SBS Medical Ltd | Health & social care | 2023 |
| SBS Pharmaceuticals Ltd | Health & social care | 2022 |
| SBS Sunnah Build Solutions Ltd | Construction | 2023 |
| SBS Trans Limited | Transport & logistics | 2019 |
| SBT Trade Ltd | Real estate | 2015 |
| Sbuk Safety Limited | Other services | 2019 |
| SBW Holdings Limited | Wholesale & retail | 2023 |
| SC Civil Engineering Limited | Construction | 2019 |
| SC Optical Limited | Health & social care | 2024 |
| SC Pharm Solutions Ltd | Health & social care | 2026 |
| Scaffvator Ltd | Construction | 2026 |
| Scalable IT Solutions Ltd | Information & communication | 2020 |
| Scalable Tech Ltd | Information & communication | 2022 |
| Scandicteck Limited | Wholesale & retail | 2026 |
| Scarborough Mobiles Ltd | Wholesale & retail | 2025 |
| Scarlet Heights @ Queensbury Private Day Nursery Limited | Health & social care | 2017 |
| Scarmasai Technology Limited | Wholesale & retail | 2025 |
| Scartechnic Limited | Professional & scientific | 2013 |
| Scarwood 3 Limited | Real estate | 2022 |
| Scemthorpe Limited | Professional & scientific | 1984 |
| Scene Kitchens Ltd | Hospitality | 2024 |
| Scent and Sole Wholesale Ltd | Wholesale & retail | 2026 |
| Scent Flex Ltd | Wholesale & retail | 2024 |
| SCENT4U Limited | Wholesale & retail | 2025 |
| Scents and Sparkle Limited | Wholesale & retail | 2020 |
| Schedule 1 Limited | Transport & logistics | 2025 |
| Schofield Sweeney LLP | | 2002 |
| Schofield Sweeney Trust Corporation Limited | Administrative & support | 2025 |
| School of Rock & Media Limited | Information & communication | 2013 |
| School of Steering Ltd | Information & communication | 2025 |
| School Sports Coaching Ltd | Education | 2024 |
| Schosween 12 Limited | Professional & scientific | 2013 |
| Schosween 6 Limited | Professional & scientific | 2012 |
| Science Development & Research Pharma Ltd | Manufacturing | 2020 |
| SCM6 Ltd | Professional & scientific | 2024 |
| Scooda Ltd | Information & communication | 2024 |
| Scoots Solutions Limited | Wholesale & retail | 2022 |
| Scope Healthcare Limited | Health & social care | 2024 |
| Scothern Solutions Ltd | Real estate | 2018 |
| Scotties Sportsbar Ltd | Hospitality | 2013 |
| Scotts Construction & Landscaping Ltd | Construction | 2023 |
| Scrap Crafters CIC | Education | 2023 |
| Scrap That Limited | Wholesale & retail | 2022 |
| Scraptastic CIC | Water & waste | 2018 |
| Scriptem Recruitment Limited | Administrative & support | 2024 |
| Scrub N Swipe Ltd | Administrative & support | 2024 |
| Scruples Hair Company Limited | Other services | 2005 |
| SCS Assessing Ltd | Education | 2024 |
| Sculpt Education Limited | Health & social care | 2014 |
| SD & S Properties Limited | Households | 2025 |
| SD Kebab Shop Ltd | Hospitality | 2019 |
| SD Preformance & Prestige Cars Ltd | Wholesale & retail | 2025 |
| SDA Couriers Limited | Transport & logistics | 2025 |
| Sdba Ltd | Real estate | 2019 |
| SDC International Ltd | Professional & scientific | 2001 |
| SDF Global Events Ltd | Administrative & support | 2020 |
| SDH Tutoring Ltd | Education | 2025 |
| SDM Recoveries Ltd | Transport & logistics | 2020 |
| SDR Group Holdings Ltd | Financial services | 2022 |
| Sea Aesthetics Limited | Health & social care | 2020 |
| Sea World Restaurant MCR Ltd | Hospitality | 2022 |
| Seabrook Crisps Holdings Limited | Administrative & support | 2002 |
| Seabrook Crisps Limited | Manufacturing | 1949 |
| Seaham Limited | Wholesale & retail | 2025 |
| Seal a Pipe UK Ltd | Construction | 2018 |
| Seal International Limited | Extraterritorial | 1972 |
| Seal South Africa Limited | Extraterritorial | 1971 |
| Sealpress Limited | Wholesale & retail | 1984 |
| Seam and SEW Limited | Wholesale & retail | 2025 |