| Rhubarb Rhubarb Catering Limited | Hospitality | 2024 |
| Rhywood Limited | Health & social care | 2018 |
| Rick Ashley Mechanical Services Ltd | Professional & scientific | 2020 |
| Riva Cycling Ltd. | Arts & recreation | 2020 |
| RJB Electrical Contractors Limited | Construction | 2006 |
| RJS Project Management Limited | Professional & scientific | 2023 |
| Robert M Wood (Hull) Ltd | Real estate | 2008 |
| Robert Mews Ltd | Real estate | 2017 |
| Robur Products Limited | Extraterritorial | 2021 |
| Roman Way Brewery Limited | Manufacturing | 2019 |
| Roome Services Ltd | Manufacturing | 2024 |
| Rooted in Wool Ltd | Professional & scientific | 2026 |
| Roscoe Cutting Consulting Ltd | Professional & scientific | 2024 |
| Rose Catering Events (UK) Limited | Hospitality | 2022 |
| Roselles Hospitality Limited | Hospitality | 2022 |
| Rous Plumbing and Heating Ltd | Construction | 2024 |
| Rover Leigh Properties Limited | Real estate | 2014 |
| RR Composites Ltd | Manufacturing | 2019 |
| RS2020 Limited | Administrative & support | 2020 |
| RST Management Limited | Real estate | 2003 |
| Rubecula Consulting Limited | Professional & scientific | 2023 |
| Rubix Fire Solutions Ltd | Public administration | 2024 |
| RUF (UK) Limited | Information & communication | 2015 |
| Rushmore Advisory Ltd | Professional & scientific | 2026 |
| Russell Scaffolding & Access Ltd | Construction | 2013 |
| Russells Rentals Limited | Real estate | 2023 |
| Russells Vehicle Management Limited | Transport & logistics | 2014 |
| Ruth Bubb Limited | Arts & recreation | 2012 |
| RV Telecoms Limited | Information & communication | 2016 |
| RWC Properties Ltd | Real estate | 2017 |
| Ryan Price Automotive Ltd | Wholesale & retail | 2026 |
| S Andrews Tiling Limited | Construction | 2009 |
| S D R B Joinery Limited | Manufacturing | 2013 |
| S M Buick Limited | Health & social care | 2010 |
| S Pearce Roofing Ltd | Construction | 2021 |
| S R M Hygiene Services Limited | Health & social care | 2017 |
| S R Smith & Sons Ltd | Wholesale & retail | 2024 |
| S. a. Moore Plumbing & Heating Services Ltd | Construction | 2018 |
| S. J. Tyres, Limited | Wholesale & retail | 2016 |
| S.R. Housing Investments Limited | Real estate | 2021 |
| S2V Associates Limited | Education | 2014 |
| Saffron Fine Dining Ltd | Hospitality | 2026 |
| Saffron Kitchen Brackley Ltd | Hospitality | 2024 |
| Sail Street Holdings Limited | Financial services | 2018 |
| Salusinvest General Partners Limited | Professional & scientific | 2006 |
| Salvari Limited | Wholesale & retail | 2018 |
| SAM Catering Ltd | Hospitality | 2025 |
| Samizdat Productions Ltd | Information & communication | 2021 |
| Sams Manor Ltd | Administrative & support | 2017 |
| Sanctuary Venues Ltd | Arts & recreation | 2014 |
| Sand Surgical Ltd | Health & social care | 2024 |
| SANDY56 Limited | Financial services | 2021 |
| Savage Empire Ltd | Real estate | 2020 |
| Schooling for Life Limited | Financial services | 2011 |
| Schubert Inspection Services Ltd | Manufacturing | 2022 |
| Scott Paxton Carpentry Limited | Construction | 2012 |
| Scrapbook Pictures Limited | Information & communication | 2023 |
| SDG Consulting Ltd | Professional & scientific | 2026 |
| Seabrook Properties Limited | Real estate | 2017 |
| Seafood Fishbar Limited | Hospitality | 2015 |
| Seamless Ventures Ltd | Manufacturing | 2024 |
| Sean Works Ltd | Construction | 2015 |
| Searchaid Limited | Administrative & support | 2008 |
| Secure Move Logistics Limited | Transport & logistics | 2025 |
| Self Drive 123 Ltd | Administrative & support | 2025 |
| Self Storage 123 Ltd | Transport & logistics | 2024 |
| Sellmywardrobe Ltd | Wholesale & retail | 2026 |
| Sen-Ed Holdings Ltd | Financial services | 2026 |
| Sen-Ed Kitchen Ltd | Education | 2024 |
| Serendipiti (IT Services) Limited | Information & communication | 2004 |
| SET Piece Partners Ltd | Information & communication | 2026 |
| SET2SET Scenic Limited | Arts & recreation | 2022 |
| SH Improvements Ltd | Households | 2024 |
| Shakespeare Road Property Investment Ltd | Real estate | 2018 |
| Shed & Co Catering Ltd | Hospitality | 2025 |
| Shepherd Heights Limited | Health & social care | 2016 |
| Shepherd-Smith Consulting Ltd | Wholesale & retail | 2023 |
| Sherbet Rewards & Motivation Technologies Limited | Information & communication | 2023 |
| Shift Motorsport Limited | Arts & recreation | 2000 |
| Shift Nutrition Ltd | Manufacturing | 2025 |
| Shire Agricultural & Fencing Supplies Ltd | Wholesale & retail | 2020 |
| Shirestone Windows & Doors Ltd | Construction | 2024 |
| Shiva Diva Limited | Hospitality | 2016 |
| Shkf Property Ltd | Real estate | 2022 |
| Short Property Ventures Ltd | Real estate | 2024 |
| SHS Business Consultancy Ltd | Professional & scientific | 2021 |
| SHS Property Services Ltd | Real estate | 2022 |
| Sicem Solutions Limited | Professional & scientific | 2013 |
| SIG 17 Briar Walk Limited | Real estate | 2017 |
| Sigma Developments Limited | Construction | 2006 |
| Silk Pillo Ltd | Hospitality | 2017 |
| Silly Old Goose Ltd | Professional & scientific | 2022 |
| SILVERFOX-CONSULTING2COACHING Ltd | Arts & recreation | 2021 |
| Silverstone Woodlands Campsite Limited | Extraterritorial | 2010 |
| Silverstone Wraps Ltd | Professional & scientific | 2022 |
| Simadart Limited | Administrative & support | 2021 |
| Simply Property Group Limited | Real estate | 2017 |
| Sitting Duck Music & Media Limited | Information & communication | 2007 |
| SJ6 Promotions Ltd | Arts & recreation | 2017 |
| Skin & Co. Ltd | Other services | 2019 |